Results 71 to 80 of about 32,558 (245)

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Triacylglycerol‐Based Insulin Resistance Indices and Post‐Transplantation Diabetes Mellitus After Liver Transplantation

Lipids, EarlyView.
ABSTRACT Background: Post‐transplant diabetes mellitus (PTDM) is a common complication following liver transplant (LT) and is associated with adverse outcomes. The triacylglycerol‐glucose product (TyG) and the triacylglycerol‐to‐high‐density lipoprotein (HDL) cholesterol ratio (TAG/HDL‐c) are indices that can serve as triacylglycerol‐based proxies for ...
Mateo Chvatal‐Medina, Yakun Li, Adrian Post, Margery A. Connelly, Han Moshage, Stephan J. L. Bakker, Vincent E. de Meijer, Hans Blokzijl, Robin P. F. Dullaart, on behalf of TransplantLines investigators   +9 more
wiley   +1 more source

Calcineurin/nfat signaling in chondrocyte differentiation: NFAT is a crucial negative regulator of early chondrogenesis [PDF]

Osteoarthritis and Cartilage, 2014
s / Osteoarthritis and Cartilage 22 (2014) S57–S489 S171 and reduced expression of the proliferation marker PCNA and aggrecan upon stimulation with BCP crystals. Micromass cultures of wild type and ttw/ttw chondrocytes revealed that BCP crystals induce production of highly sulphated and calcified matrix.
Kim, G., Han, M., Lee, E., Jung, Y., Park, H., Han, S.   +5 more
openaire   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Calcium/NFAT signalling promotes early nephrogenesis [PDF]

, 2011
A number of Wnt genes are expressed during, and are known to be essential for, early kidney development. It is typically assumed that their products will act through the canonical β-catenin signalling pathway.
Burn, S.F., Davies, J.A., R.L. Berry, Hadjantonakis, A K, Berry, R L, Hohenstein, P, Hadjantonakis, A.K., Hastie, N D, A.K. Hadjantonakis, J.A. Davies, Davies, J A, Ferrer-Vaquer, A, Burn, S F, Webb, A, P. Hohenstein, Berry, R.L., S.F. Burn, N.D. Hastie, A. Ferrer-Vaquer, Ferrer-Vaquer, A., Hohenstein, P., A. Webb, Webb, A., Hastie, N.D.   +23 more
core   +1 more source

Pharmacodynamic monitoring by residual gene expression of the nuclear factor of activated T cell-regulated genes in lung transplant recipients and its correlation with tacrolimus blood levels

Frontiers in Immunology
IntroductionTrough blood levels (C0) of tacrolimus are used to adjust drug dosage, but they do not consistently correlate with clinical outcomes. Measurement of residual gene expression of nuclear factor of activated T cell (NFAT)-regulated genes (NFAT ...
Meritxell Boada-Pérez, Meritxell Boada-Pérez, Victoria Ruiz de Miguel, Marta Erro, Piedad Ussetti, Myriam Aguilar, Raquel Castejón, Silvia Rosado, Roser Escobar-Fornieles, Eva Revilla-López, Carlos Bravo, Carlos Bravo, Berta Sáez-Giménez, Berta Sáez-Giménez, Marta Zapata-Ortega, Marta Zapata-Ortega, Yolanda Villena-Ortiz, Jaume Vima-Bofarull, Víctor Monforte, Víctor Monforte, Susana Gómez-Ollés, Susana Gómez-Ollés   +21 more
doaj   +1 more source

Is the Antiproteinuric Effect of Cyclosporine A Independent of Its Immunosuppressive Function in T Cells?

International Journal of Nephrology, 2012
The antiproteinuric effect of cyclosporine A(CsA) has been believed to result from its immunosuppressive effect on the transcription factor NFAT in T cells. However, current evidences supporting this hypothesis are missing. A recent study showed that CsA
Bin Zhang, Wei Shi
doaj   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Steffen, Imke, Kögl, Manfred, Schwegmann-Wessels, Christel, Pumpor, Ksenia, Müller, Marcel A., Herzog, Petra, Kuri, Thomas, Ditt, Vanessa, Weber, Friedemann, Schwarz, Frank, Pfefferle, Susanne, Schöpf, Julia, Kallies, Stefan, Herrler, Georg, Carbajo-Lozoya, Javier, Zimmer, Ralf, Hilgenfeld, Rolf, Friedel, Caroline C., Dall'Armi, Ekatarina von, Drosten, Christian, Niemeyer, Daniela, Thiel, Volker, Züst, Roland, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Pöhlmann, Stefan, Haas, Juergen G.   +27 more
core   +1 more source

Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma

Cell Reports, 2019
Summary: Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range ...
Angela R. Wild, Brooke L. Sinnen, Philip J. Dittmer, Matthew J. Kennedy, William A. Sather, Mark L. Dell’Acqua   +5 more
doaj   +1 more source