Results 71 to 80 of about 41,205 (276)

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells

Cell Reports, 2018
Summary: Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is
Esteban J. Rozen, Julia Roewenstrunk, María José Barallobre, Chiara Di Vona, Carole Jung, Ana F. Figueiredo, Jeroni Luna, Cristina Fillat, Maria L. Arbonés, Mariona Graupera, Miguel A. Valverde, Susana de la Luna   +11 more
doaj   +1 more source

Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population

Endocrine Connections, 2022
Cardiovascular risk factors could be present in mild adrenal au tonomous cortisol secretion (MACS). However, the most frequent cardiovascular risk factors in MACS have not been established.
Agnieszka Adamska, Vitalii Ulychnyi, Katarzyna Siewko, Anna Popławska-Kita, Małgorzata Szelachowska, Marcin Adamski, Angelika Buczyńska, Adam Jacek Krętowski   +7 more
doaj   +1 more source

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s

Journal of Experimental Medicine, 2017
Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung.
J. von Moltke, C. O'Leary, N. Barrett, Y. Kanaoka, K. F. Austen, Richard M. Locksley   +5 more
semanticscholar   +1 more source

Mathematics of the NFAT Signaling Pathway

SIAM Journal on Applied Dynamical Systems, 2012
This paper is a mathematical study of some aspects of the signalling pathway leading to the activation of the transcription factor NFAT (nuclear factor of activated T cells). Activation takes place by dephosphorylation at multiple sites. This has been modelled by Salazar and Höfer using a large system of ordinary differential equations depending on ...
openaire   +4 more sources

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. [PDF]

PLoS ONE, 2011
Sustained pressure overload leads to compensatory myocardial hypertrophy and subsequent heart failure, a leading cause of morbidity and mortality.
Alexandra V Finsen, Ida G Lunde, Ivar Sjaastad, Even K Østli, Marianne Lyngra, Hilde O Jarstadmarken, Almira Hasic, Ståle Nygård, Sarah A Wilcox-Adelman, Paul F Goetinck, Torstein Lyberg, Biljana Skrbic, Geir Florholmen, Theis Tønnessen, William E Louch, Srdjan Djurovic, Cathrine R Carlson, Geir Christensen   +17 more
doaj   +1 more source

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling

Genes & Development, 2018
Here, Lee et al. investigated the molecular mechanisms by which acetyl-CoA production impacts gene expression and how acetyl-CoA promotes malignant phenotypes.
Joyce V. Lee, C. Berry, K.-A. Kim, Payel Sen, Taehyong Kim, Alessandro Carrer, S. Trefely, Steven Zhao, Sully Fernandez, Lauren E. Barney, Alyssa D. Schwartz, Shelly R. Peyton, N. Snyder, S. Berger, Bruce D. Freedman, K. Wellen   +15 more
semanticscholar   +1 more source

Duvelisib is a novel NFAT inhibitor that mitigates adalimumab-induced immunogenicity

Frontiers in Pharmacology
IntroductionTNFα inhibitor (TNFi) immunogenicity in rheumatoid arthritis (RA) is a major obstacle to its therapeutic effectiveness. Although methotrexate (MTX) can mitigate TNFi immunogenicity, its adverse effects necessitate alternative strategies ...
Aboli Bhingarkar, Yuyin Wang, Keito Hoshitsuki, Katherine Marie Eichinger, Katherine Marie Eichinger, Sanjay Rathod, Yin Zhu, He Lyu, Andrew T. McNutt, Larry W. Moreland, Lee McDermott, David R. Koes, Christian A. Fernandez   +12 more
doaj   +1 more source

Partners in transcription: NFAT and AP-1 [PDF]

Oncogene, 2001
Combinatorial regulation is a powerful mechanism that enables tight control of gene expression, via integration of multiple signaling pathways that induce different transcription factors required for enhanceosome assembly. The four calcium-regulated transcription factors of the NFAT family act synergistically with AP-1 (Fos/Jun) proteins on composite ...
F, Macián, C, López-Rodríguez, A, Rao
openaire   +2 more sources

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source