Results 81 to 90 of about 41,205 (276)
Selective Activation of Nfat by Promyelocytic Leukemia Protein
, 2009 Promyelocytic leukemia (PML) protein is a tumor suppressor with complicated action mechanisms not yet fully understood. In this study, we found that the nuclear factor of activated T cell ( NFAT) is an unexpected partner of PML: PML specifically enhanced
駱育壎;施修明;賴明宗 +1 more
core +1 more source
NFATc3 and VIP in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease.
PLoS ONE, 2017 Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are both debilitating lung diseases which can lead to hypoxemia and pulmonary hypertension (PH).
Anthony M Szema +10 more
doaj +1 more source
TNF-α contributes to caspase-3 independent apoptosis in neuroblastoma cells: role of NFAT. [PDF]
PLoS ONE, 2011 There is increasing evidence that soluble factors in inflammatory central nervous system diseases not only regulate the inflammatory process but also directly influence electrophysiological membrane properties of neurons and astrocytes.
Susana Alvarez +3 more
doaj +1 more source
ERK inhibition and 3D spheroids increased NFAT transactivation.
, 2014 HeyA8 cells plated at 50,000 cells in a 24 well plate for transfections. 500 ng of NFAT-Luc/Renilla mixture (40:1) were transfected per well and incubated overnight.
Keven Huang (675616) +2 more
core +1 more source
PLoS ONE, 2017 Calsequestrin-2 (CASQ2) is the main Ca2+-binding protein inside the sarcoplasmic reticulum of cardiomyocytes. Previously, we demonstrated that MEF-2 and SRF binding sites within the human CASQ2 gene (hCASQ2) promoter region are functional in neonatal ...
Rafael Estrada-Avilés +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mutations of H-Ras, a member of the RAS family, are preferentially found in cutaneous squamous cell carcinomas (SCCs). H-Ras has been reported to induce autophagy, which plays an essential role in tissue homeostasis in multiple types of cancer cells and ...
Shuangshuang Wang +14 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki +8 more
wiley +1 more source
NFAT activation in PC12 cells with reduce PMCAs content.
, 2014 PC12 cells were transfected with plasmids encoding firefly luciferase under NFAT-dependent promoter (pGL3-NFAT-luc) and reference plasmids with Renilla luciferase (pRL-SV40).
Ludmila Zylinska (542407) +3 more
core +1 more source
NFAT as cancer target: Mission possible? [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014 The NFAT signaling pathway regulates various aspects of cellular functions; NFAT acts as a calcium sensor, integrating calcium signaling with other pathways involved in development and growth, immune response, and inflammatory response. The NFAT family of transcription factors regulates diverse cellular functions such as cell survival, proliferation ...
Jiang-Jiang, Qin +6 more
openaire +2 more sources
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source