Results 101 to 110 of about 32,558 (245)
In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells
Experimental Physiology, EarlyView.Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene +4 more
wiley +1 more source
F1000Research, 2018 Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca2+/calcineurin-regulated transcription factor in T cells. Since then, a large body of research uncovered the regulation and physiological function of different
Martin Vaeth, Stefan Feske
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani +5 more
wiley +1 more source
, 2012 [[abstract]]Evidences suggest that lipopolysaccharide (LPS) participates in the inflammatory response in the cardiovascular system; however, it is unknown if LPS is sufficient to cause the cardiac hypertrophy.
Liu, Chung-Jung;Cheng, Yi-Chang;Lee, Kung-Wei;Hsu, Hsi-Hsien;Chu, Chun-Hsien;Tsai, Fuu-Jen ;Tsai, Chang-Hai;Chu, Chia-Yih;Liu, Jer-Yuh;Kuo, Wei-Wen;黃志揚;HUANG, CHIH-YANG
core
The calcineurin-NFAT pathway and muscle fiber-type gene expression
, 2000 To test for a role of the calcineurin-NFAT (nuclear factor of activated T cells) pathway in the regulation of fiber type-specific gene expression, slow and fast muscle-specific promoters were examined in C2C12 myotubes and in slow and fast muscle in the ...
Susan C. Kandarian +7 more
core +1 more source
, 2015 Streptococcus pyogenes of the M1 serotype can cause STSS, which is associated with significant morbidity and mortality. The purpose of the present study was to examine the role of NFAT signaling in M1 protein-induced lung injury.
Gomez, Maria +5 more
core +2 more sources
NFAT Signaling in Osteoblasts Regulates the Hematopoietic Niche in the Bone Microenvironment
Clinical and Developmental Immunology, 2013 Osteoblasts support hematopoietic cell development, including B lymphopoiesis. We have previously shown that the nuclear factor of activated T cells (NFAT) negatively regulates osteoblast differentiation and bone formation.
Cheryl L. Sesler, Majd Zayzafoon
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler +6 more
wiley +1 more source
NFAT promotes carcinoma invasive migration through glypican-6
, 2011 Invasive migration of carcinoma cells is a prerequisite for the metastatic dissemination of solid tumours. Numerous mechanisms control the ability of cancer cells to acquire a motile and invasive phenotype, and subsequently degrade and invade the ...
Gary K. Yiu +3 more
core +1 more source