Results 91 to 100 of about 32,558 (245)
A role for NFAT signaling in ABC-DLBCL
Blood, 2020 In this issue of Blood, Bucher et al investigate the role of calcium-induced nuclear factor of activated T cells (NFAT) signaling in subtypes of diffuse large B-cell lymphoma (DLBCL) and identify a potential therapeutic vulnerability in a subtype of the disease.
openaire +3 more sources
The role of acquired host immunity in periodontal diseases
Periodontology 2000, EarlyView.Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane +2 more
wiley +1 more source
Inflammation and mechanical force‐induced bone remodeling
Periodontology 2000, EarlyView.Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon +6 more
wiley +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
, 2014 (A, B) HEK 293 cells were co-transfected with a Myc-tagged of SIRT1 and HA-tagged of NFAT expression vectors, and were analyzed using co-immunoprecipitation and western blotting. The images are representative of three independent experiments.
Yan-Zhen Wan (568221) +13 more
core +1 more source
Physiological Reports, 2020 Calcineurin is a Ca2+‐dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus.
Kennedy C. Whitley +8 more
doaj +1 more source
Veterinary Dermatology, EarlyView.Background: Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined.
Treasa Clifford +5 more
wiley +1 more source
The Role of the NFAT Signaling Pathway in Retinal Neovascularization
, 2020 Citation: Bretz CA, Savage S, Capozzi M, Penn JS. The role of the NFAT signaling pathway in retinal neovascularization. Invest Ophthalmol Vis Sci. 2013;54:7020-7027. DOI: 10.1167/iovs.13-12183 PURPOSE.
Colin A Bretz +3 more
core
Cutting Edge: Tubulin α Functions as an Adaptor in NFAT–Importin β Interaction
, 2011 Upon T cell stimulation, NFAT is dephosphorylated by calcineurin, leading to nuclear translocation via NFAT–importin β interaction. Whereas the process of NFAT dephosphorylation has been well researched, the molecular mechanism of NFAT–importin β ...
Osamu Watanabe +4 more
core +1 more source
Frontiers in Immunology, 2018 The Parkinson’s disease-associated protein, Leucine-rich repeat kinase 2 (LRRK2), a known negative regulator of nuclear factor of activated T cells (NFAT), is expressed in myeloid cells such as macrophages and dendritic cells (DCs) and is involved in the
Alicia Yoke Wei Wong +12 more
doaj +1 more source