Results 91 to 100 of about 41,205 (276)

NFAT single-deficient murine T cells reduce the risk of aGvHD while controlling cytomegalovirus infection

iScience
Summary: NFAT is a family of transcription factors whose activation is inhibited by calcineurin inhibitors (CNIs). In allogeneic hematopoietic stem cell transplantation (allo-HCT), CNIs are employed to prevent and treat graft-versus-host disease (GvHD ...
Nadine Hundhausen, Snigdha Majumder, Yin Xiao, Sigrun S. Haeusl, Helen Goehler, Rishav Seal, Cristina M. Chiarolla, Andreas Rosenwald, Matthias Eyrich, Luka Cicin-Sain, Friederike Berberich-Siebelt   +10 more
doaj   +1 more source

NFAT primes the human RORC locus for RORγt expression in CD4+ T cells

Nature Communications, 2019
T helper 17 (Th17) cells have crucial functions in mucosal immunity and the pathogenesis of several chronic inflammatory diseases. The lineage-specific transcription factor, RORγt, encoded by the RORC gene modulates Th17 polarization and function, as ...
Hanane Yahia-Cherbal, M. Rybczynska, Domenica Lovecchio, Tharshana Stephen, C. Lescale, K. Placek, J. Larghero, L. Rogge, E. Bianchi   +8 more
semanticscholar   +1 more source

NFAT in Pancreatic Carcinogenesis [PDF]

Journal of Carcinogenesis & Mutagenesis, 2014
Pancreatic Ductal Adenocarcinoma (PDAC) belongs to the most aggressive malignancies among solid tumors. The increasing incidence of PDAC and its dismal prognosis with a five-years overall survival rate of less than five percent characterize PDAC as one of the most clinically challenging diseases among all malignancies.
openaire   +1 more source

SH3BP2 is an activator of NFAT activity and osteoclastogenesis [PDF]

Biochemical and Biophysical Research Communications, 2008
Heterozygous activating mutations in exon 9 of SH3BP2 have been found in most patients with cherubism, an unusual genetic syndrome characterized by excessive remodeling of the mandible and maxilla due to spontaneous and excessive osteoclastic bone resorption.
Steven A, Lietman, Lihong, Yin, Michael A, Levine   +2 more
openaire   +2 more sources

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Pharmacodynamic monitoring by residual gene expression of the nuclear factor of activated T cell-regulated genes in lung transplant recipients and its correlation with tacrolimus blood levels

Frontiers in Immunology
IntroductionTrough blood levels (C0) of tacrolimus are used to adjust drug dosage, but they do not consistently correlate with clinical outcomes. Measurement of residual gene expression of nuclear factor of activated T cell (NFAT)-regulated genes (NFAT ...
Meritxell Boada-Pérez, Meritxell Boada-Pérez, Victoria Ruiz de Miguel, Marta Erro, Piedad Ussetti, Myriam Aguilar, Raquel Castejón, Silvia Rosado, Roser Escobar-Fornieles, Eva Revilla-López, Carlos Bravo, Carlos Bravo, Berta Sáez-Giménez, Berta Sáez-Giménez, Marta Zapata-Ortega, Marta Zapata-Ortega, Yolanda Villena-Ortiz, Jaume Vima-Bofarull, Víctor Monforte, Víctor Monforte, Susana Gómez-Ollés, Susana Gómez-Ollés   +21 more
doaj   +1 more source

Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

Nature Communications, 2018
Oligodendrocytes produce myelin for rapid transmission and saltatory conduction of action potentials in the vertebrate central nervous system. Activation of the myelination program requires several transcription factors including Sox10, Olig2, and Nkx2.2.
Matthias Weider, Laura Starost, Katharina Groll, Melanie Küspert, E. Sock, Miriam Wedel, Franziska Fröb, Christian Schmitt, Tina Baroti, Anna C. Hartwig, Simone Hillgärtner, Sandra Piefke, Tanja Fadler, Marc Ehrlich, Corinna Ehlert, M. Stehling, Stefanie Albrecht, Ammar Jabali, H. Schöler, J. Winkler, T. Kuhlmann, M. Wegner   +21 more
semanticscholar   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Is the Antiproteinuric Effect of Cyclosporine A Independent of Its Immunosuppressive Function in T Cells?

International Journal of Nephrology, 2012
The antiproteinuric effect of cyclosporine A(CsA) has been believed to result from its immunosuppressive effect on the transcription factor NFAT in T cells. However, current evidences supporting this hypothesis are missing. A recent study showed that CsA
Bin Zhang, Wei Shi
doaj   +1 more source

AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels

Molecular Biology of the Cell, 2019
In neurons, regulation of activity-dependent transcription by the nuclear factor of activated T-cells (NFAT) depends upon Ca2+ influx through voltage-gated L-type calcium channels (LTCC) and NFAT translocation to the nucleus following its ...
Jonathan G. Murphy, Kevin C. Crosby, Philip J Dittmer, W. Sather, M. Dell'Acqua   +4 more
semanticscholar   +1 more source