Results 111 to 120 of about 41,205 (276)

Cell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old player

Cell Death and Disease, 2016
The NFAT (nuclear factor of activated T cells) family of transcription factors consists of four Ca2+-regulated members (NFAT1–NFAT4), which were first described in T lymphocytes.
G. Mognol, Flávia R. G. Carneiro, B. K. Robbs, Douglas V. Faget, J. P. Viola   +4 more
semanticscholar   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases

Journal of Aging Research, 2016
The ongoing epidemics of metabolic diseases and increase in the older population have increased the incidences of neurodegenerative diseases. Evidence from murine and cell line models has implicated calcineurin-nuclear factor of activated T-lymphocytes ...
Maulilio John Kipanyula, Wahabu Hamisi Kimaro, Paul F. Seke Etet   +2 more
doaj   +1 more source

Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats

Cellular Physiology and Biochemistry, 2018
Background/Aims: Pulmonary arterial hypertension (PAH) is a severe and debilitating disease characterized by remodeling of the pulmonary vessels, which is driven by excessive proliferation and migration and apoptosis resistance in pulmonary artery smooth
Rui-Lan He, Zhi-Juan Wu, Xiao-Ru Liu, Long-Xin Gui, Rui-Xing Wang, Mo-Jun Lin   +5 more
semanticscholar   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis–trans isomerase Pin1 [PDF]

, 2001
Nuclear factor of activated T cells (NFAT) plays a key role in T cell activation. The activation of NFAT involves calcium- and calcineurin-dependent dephosphorylation and nuclear translocation from the cytoplasm, a process that is opposed by protein ...
Kun Ping Lu, Lu, Kun Ping, Jun O. Liu, Liu, Weifeng, Hong-Duk Youn, Liu, Jun O., Weifeng Liu, Youn, Hong-Duk, Zhou, Xiao Zhen, Xiao Zhen Zhou   +9 more
core   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

The rs2275913 SNP results in differential binding of NFAT.

, 2013
(A) The location of the rs2275913 SNP within the promoter region of the IL-17 gene. The underlined sequence corresponds to the oligomers used in EMSA assay. The NFAT binding sites [21] are indicated in red and by red boxes.
Akiyoshi Takami (113619), Yoshihisa Kodera (341465), Koichi Miyamura (341463), Katsuya Nakata (341459), Takakazu Kawase (341461), Makoto Onizuka (341460), Takahiro Fukuda (180688), Yasuo Morishima (341464), J. Luis Espinoza (113614), Hideki Akiyama (341462), Shinji Nakao (80889)   +10 more
core   +1 more source

Calcium/NFAT signalling promotes early nephrogenesis [PDF]

, 2011
A number of Wnt genes are expressed during, and are known to be essential for, early kidney development. It is typically assumed that their products will act through the canonical β-catenin signalling pathway.
Burn, S.F., Davies, J.A., R.L. Berry, Hadjantonakis, A K, Berry, R L, Hohenstein, P, Hadjantonakis, A.K., Hastie, N D, A.K. Hadjantonakis, J.A. Davies, Davies, J A, Ferrer-Vaquer, A, Burn, S F, Webb, A, P. Hohenstein, Berry, R.L., S.F. Burn, N.D. Hastie, A. Ferrer-Vaquer, Ferrer-Vaquer, A., Hohenstein, P., A. Webb, Webb, A., Hastie, N.D.   +23 more
core   +1 more source

Imaging TCR-Dependent NFAT-Mediated T-Cell Activation with Positron Emission Tomography In Vivo

Neoplasia: An International Journal for Oncology Research, 2001
A noninvasive method for molecular imaging of T-cell activity in vivo would be of considerable value. It would aid in understanding the role of specific genes and signal transduction pathways in the course of normal and pathologic immune responses, could
Vladimir Ponomarev, Michael Doubrovin, Clay Lyddane, Tatiana Beresten, Julius Balatoni, William Bornman, Ronald Finn, Timothy Akhurst, Steven Larson, Ronald Blasberg, Michel Sadelain, Juri Gelovani Tjuvajev   +11 more
doaj   +1 more source