Results 131 to 140 of about 32,558 (245)
, 2014 The purpose of this investigation was to characterize the nuclear localisation patterns of NFAT-c1, -c2, -c3, and -c4 in relation to chronic low-frequency stimulation induced fibre type transitions.
McDonald, Pamela C
core +1 more source
T Cell Exhaustion as a Regulated Differentiation Programme
European Journal of Immunology, Volume 56, Issue 6, June 2026.This review highlights T cell exhaustion as an adaptive differentiation trajectory, not dysfunction, showing how precursor, intermediate, and terminal exhausted states maintain antigen recognition while limiting tissue damage in chronic immune activation.
Marc Veldhoen, Cristina Ferreira
wiley +1 more source
T cell signalling, from calcium to NFAT: A mathematical model.
, 2017 Full text is available to authenticated members of The University of Auckland only.Intracellular calcium in T cells is an important control mechanism for immune response.
Cloete, Ielyaas
core
Oxytocin-Stimulated NFAT Transcriptional Activation in Human Myometrial Cells
, 2012 Oxytocin (OXT) is a peptide hormone that binds the OXT receptor on myometrial cells, initiating an intracellular signaling cascade, resulting in accumulation of intracellular calcium and smooth muscle contraction.
McArdle, Craig A +2 more
core +1 more source
FishesThe blood clam (Anadara granosa) is an economic bivalve that is relatively tolerant to hypoxia, but its molecular mechanism of hypoxia tolerance is unclear. We found that a significant decrease in extracellular Ca2+ concentration and a marked increase in
Yang Zhang +3 more
doaj +1 more source
Targeting the Calcineurin-NFAT Interaction by Solution NMR Spectroscopy
, 2015 The serine/threonine phosphatase calcineurin (Cn) targets the nuclear factors of activated T cells (NFATs) that activate cytokine genes. Calcium influx activates Cn to dephosphorylate multiple serine residues within the ~200 residue NFAT regulatory ...
Li, Shuai
core
NFATs and Alzheimer's Disease.
Molecular and cellular pharmacologyNuclear factor of activated T cells (NFAT) is a transcription factor that translocates from cytosol to nucleus following dephosphorylation by the Ca(2+)/calmodulin dependent protein phosphatase calcineurin (CN). In nervous tissue, aberrant CN signaling is increasingly linked to a variety of pathologic features associated with Alzheimer's disease (AD ...
Hafiz Mohmmad, Abdul +4 more
openaire +1 more source
Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives
MedComm – Oncology, Volume 5, Issue 2, June 2026.Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang +14 more
wiley +1 more source
Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells
, 2007 We have reported previously that p115Rho guanine nucleotide exchange factor, its upstream activator Gα13, and its effector RhoA are able to inhibit HIV-1 replication.
Holmes, Derek A. +11 more
core +1 more source
Aging Cell, Volume 25, Issue 6, June 2026.Aging impairs vaccine efficacy through gut microbiota dysbiosis and mTOR hyperactivation, which together drive inflammaging and weaken immune memory. This review highlights the bidirectional microbiota–mTOR axis and proposes that combining mTOR inhibitors with microbiota modulation offers a promising strategy to enhance vaccine responses in older ...
Jiaxuan Li +5 more
wiley +1 more source