Results 131 to 140 of about 41,205 (276)
A role for NFAT signaling in ABC-DLBCL
Blood, 2020 In this issue of Blood, Bucher et al investigate the role of calcium-induced nuclear factor of activated T cells (NFAT) signaling in subtypes of diffuse large B-cell lymphoma (DLBCL) and identify a potential therapeutic vulnerability in a subtype of the disease.
openaire +3 more sources
The role of acquired host immunity in periodontal diseases
Periodontology 2000, EarlyView.Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane +2 more
wiley +1 more source
, 2012 [[abstract]]Evidences suggest that lipopolysaccharide (LPS) participates in the inflammatory response in the cardiovascular system; however, it is unknown if LPS is sufficient to cause the cardiac hypertrophy.
Liu, Chung-Jung;Cheng, Yi-Chang;Lee, Kung-Wei;Hsu, Hsi-Hsien;Chu, Chun-Hsien;Tsai, Fuu-Jen ;Tsai, Chang-Hai;Chu, Chia-Yih;Liu, Jer-Yuh;Kuo, Wei-Wen;黃志揚;HUANG, CHIH-YANG
core
Frontiers in Immunology, 2018 The Parkinson’s disease-associated protein, Leucine-rich repeat kinase 2 (LRRK2), a known negative regulator of nuclear factor of activated T cells (NFAT), is expressed in myeloid cells such as macrophages and dendritic cells (DCs) and is involved in the
Alicia Yoke Wei Wong +12 more
doaj +1 more source
Astrocyte Activation and the Calcineurin/NFAT Pathway in Cerebrovascular Disease
Frontiers in Aging Neuroscience, 2018 Calcineurin (CN) is a Ca2+/calmodulin-dependent protein phosphatase with high abundance in nervous tissue. Though enriched in neurons, CN can become strongly induced in subsets of activated astrocytes under different pathological conditions where it ...
S. Kraner, C. Norris
semanticscholar +1 more source
Inflammation and mechanical force‐induced bone remodeling
Periodontology 2000, EarlyView.Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon +6 more
wiley +1 more source
, 2014 (A, B) HEK 293 cells were co-transfected with a Myc-tagged of SIRT1 and HA-tagged of NFAT expression vectors, and were analyzed using co-immunoprecipitation and western blotting. The images are representative of three independent experiments.
Yan-Zhen Wan (568221) +13 more
core +1 more source
Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells [PDF]
, 2007 We have reported previously that p115Rho guanine nucleotide exchange factor, its upstream activator Gα13, and its effector RhoA are able to inhibit HIV-1 replication.
Holmes, Derek A. +11 more
core +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
NFAT Signaling in Osteoblasts Regulates the Hematopoietic Niche in the Bone Microenvironment
Clinical and Developmental Immunology, 2013 Osteoblasts support hematopoietic cell development, including B lymphopoiesis. We have previously shown that the nuclear factor of activated T cells (NFAT) negatively regulates osteoblast differentiation and bone formation.
Cheryl L. Sesler, Majd Zayzafoon
doaj +1 more source