T Cell Dysfunction in the Acidic Tumor Microenvironment
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Solid tumors are characterized by profound metabolic and vascular abnormalities that generate a hostile tumor microenvironment (TME) marked by extracellular acidosis, hypoxia, and nutrient deprivation. While the consequences of these conditions for cancer cell behavior have been extensively studied, their impact on anti‐tumor immune responses ...
F. B. Christiansen +4 more
wiley +1 more source
The Role of NFAT Family Transcription Factors in Diabetic Retinopathy
, 2015 Diabetic retinopathy (DR) is one of the leading causes of vision loss in working age populations. Clinically, DR is divided into early non-proliferative diabetic retinopathy (NPDR), characterized by retinal vascular inflammation, hyperpermeability, and ...
Bretz, Colin Andrew
core
Role of NFAT (nuclear factor of activated T cells) in vascular smooth muscle
, 2009 The calcium-dependent transcription factor NFAT was first described as a key player in immune cell regulation. Since then, NFAT signaling has been shown to be crucial for normal vascular development during embryogenesis. This pathway is also an important
Lund University., Berglund, Lisa,
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Modulation of NFAT-5, an outlying member of the NFAT family, in human keratinocytes and skin.
American journal of translational research, 2011 Cyclosporin A (CsA) and tacrolimus block T cell activation by inhibiting the phosphatase calcineurin and preventing translocation from the cytoplasm to the nucleus of the transcription factor Nuclear Factor of Activated T cells (NFAT). NFAT compose a family of transcription factors that are turned on during T cell activation.To study the expression of ...
Wael I, Al-Daraji +4 more
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Cancer Science, Volume 117, Issue 6, Page 1635-1650, June 2026.SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen +7 more
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha [PDF]
, 2009 Vascular complications of diabetes account for the majority of morbidity and mortality among diabetic patients. Large clinical trials have identified hyperglycemia as a risk factor in the development of diabetic vascular complications.
Öhman, Jenny
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Emerging role of DYRK1A as a target in cardiovascular diseases (Review). [PDF]
Mol Med RepYu L, Cheng Q, Wu J.
europepmc +1 more source
DejanKov2901/NFAT_translocation: NFAT translocation analysis tool
<p>This tool is designed to facilitate the analysis of NFAT translocation into the nucleus (of T cells).</p ...
DejanKov2901
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Kujiol A Inhibits Interferon-γ and Interleukin-2 Expression and the NFATc2 Interaction with Their Promoters in T Cells. [PDF]
MoleculesYodweerapong T +6 more
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TRPV6-Mediated Ca<sup>2+</sup> Signaling in Pancreatic Ductal Adenocarcinoma: From Cellular Physiology to Therapeutic Opportunities. [PDF]
Cancers (Basel)Yosef B, Venglovecz V.
europepmc +1 more source