Results 161 to 170 of about 41,205 (276)

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

T cell signalling, from calcium to NFAT: A mathematical model.

, 2017
Full text is available to authenticated members of The University of Auckland only.Intracellular calcium in T cells is an important control mechanism for immune response.
Cloete, Ielyaas
core  

Duvelisib is a novel NFAT inhibitor that attenuates adalimumab immunogenicity

, 2022
The immunogenicity of biologics is a major problem in rheumatoid arthritis (RA) because it neutralizes the activity of biologics such as adalimumab via the development of anti-drug antibodies (ADA) that can lead to disease relapse.
Bhingarkar, Aboli
core  

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

Advancing In Vivo Chimeric Antigen Receptor T‐Cell Engineering to Accelerate Clinical Translation

MedComm, Volume 7, Issue 10, October 2026.
In vivo CAR‐T cell generation directly engineers endogenous T cells using pre‐manufactured gene delivery vectors that target T cells and deliver CAR‐encoding genetic material. The resulting CAR‐T cells expand in vivo and mediate antigen‐specific cytotoxicity.
Zhenxin Bai, Ming Yi, Shengtao Hu, Dixuan Xue, Luxin Wei, Lifeng Zhang, Zhijun Dai   +6 more
wiley   +1 more source

Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretionResearch in context

EBioMedicine
Summary: Background: Benign adrenal tumours, found in 1–7% of adults, can be non-functioning (NFAT) or show mild autonomous cortisol secretion (MACS), i.e., biochemical cortisol excess without manifestations of Cushing's syndrome (CS). MACS occurs in 20–
Alessandro Prete, Lida Abdi, Marco Canducci, Elina L. van den Brandhof, Ariadna Albors-Zumel, Carl Jenkinson, Lorna C. Gilligan, Yuanqing Zhang, Ludger Visser, Vasileios Chortis, Lukáš Najdekr, Andris Jankevics, Gavin R. Lloyd, Catherine L. Winder, Stylianos Tsagarakis, Katharina Lang, Magdalena Macech, Vanessa Fell, Ivana D. Vodanovic, Giuseppe Reimondo, Ljiljana V. Marina, Timo Deutschbein, Maria Balomenaki, Michael W. O'Reilly, Tomasz Bednarczuk, Tina Dusek, Aristidis Diamantopoulos, Miriam Asia, Agnieszka Kondracka, Kai Yu, Jimmy R. Masjkur, Marcus Quinkler, Grethe Å. Ueland, M. Conall Dennedy, Felix Beuschlein, Antoine Tabarin, Martin Fassnacht, Miomira Ivovic, Massimo Terzolo, Darko Kastelan, William F. Young, Jr., Konstantinos N. Manolopoulos, Urszula Ambroziak, Dimitra A. Vassiliadi, Irina Bancos, Alice J. Sitch, Angela E. Taylor, Peter Tino, Michael Biehl, Warwick B. Dunn, Wiebke Arlt   +50 more
doaj   +1 more source

Calcineurin inhibitors and calcineurin-NFAT system

Japanese Journal of Clinical Immunology, 2010
Cyclosporin A and tacrolimus have been used as immunosuppressive agents initially in organ transplantation after their discovery, and are also used for treatment of the autoimmune disease, providing an excellent therapeutic effect. These agents act targeting on intracellular phosphatase calcineurin (CN), and subsequently inhibit activation of nuclear ...
openaire   +3 more sources

Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm, Volume 7, Issue 10, October 2026.
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo, Yizhao Xie, Rui Song, Mengdi Yang, Zhen Lin, Chao Guan, Zechen Wang, Jin Wen, Guang‐Liang Chen   +8 more
wiley   +1 more source

Strategy for modular assembly of tetravalent, multispecific antibodies

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Evan Mallette, Levi L. Blazer, Craig A. Hokanson, Chao Chen, Julia Garcia Perez, Alevtina Pavlenco, Lynda Ploder, Alexander U. Singer, Michael D. L. Suits, Sunil Bhakta, Jagath R. Junutula, Jarrett J. Adams, Sachdev S. Sidhu   +12 more
wiley   +1 more source

The Structure Analysis and mRNA Expression of CaV2 Gene Responding to Hypoxia Stress in Anadara granosa

Fishes
The blood clam (Anadara granosa) is an economic bivalve that is relatively tolerant to hypoxia, but its molecular mechanism of hypoxia tolerance is unclear. We found that a significant decrease in extracellular Ca2+ concentration and a marked increase in
Yang Zhang, Hongxing Liu, Yongbo Bao, Zhilan Peng   +3 more
doaj   +1 more source