Results 171 to 180 of about 41,205 (276)

The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor‐αKlotho Complex Increases Sinoatrial Electrical Activity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex in the kidney and parathyroid glands.
Giorgia Bertoli, Patrizia Benzoni, Serena Canzolino, David Molla, Raffaella Milanesi, Chiara Piantoni, Makoto Kuro‐o, Carmen Delgado, Gema Ruiz‐Hurtado, Mirko Baruscotti, Annalisa Bucchi   +10 more
wiley   +1 more source

Oxytocin-Stimulated NFAT Transcriptional Activation in Human Myometrial Cells

, 2012
Oxytocin (OXT) is a peptide hormone that binds the OXT receptor on myometrial cells, initiating an intracellular signaling cascade, resulting in accumulation of intracellular calcium and smooth muscle contraction.
McArdle, Craig A, Pont, Jason N A, Lopez Bernal, Andres   +2 more
core   +1 more source

N6‐Methyladenosine Demethylase FTO Protects Pancreatic ΒTC6 Cells From Cholesterol‐Triggered Damage by Regulating Nfatc4: Insights From RNA‐Seq Analysis

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
FTO Protects Mouse Pancreatic Beta‐TC‐6 cells From Cholesterol‐Triggered Damage by Repressing Nfatc4. ABSTRACT Excessive cholesterol contributes to pancreatic β‐cell dysfunction and plays a critical role in the pathogenesis of metabolic disorders.
Pingping Hong, Yongjie Li, Jiandong Lin, Lingxiao Wang, Xiaofang Fan, Hongfang Wang, Luping Lou   +6 more
wiley   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, Volume 65, Issue 10, Page 2038-2048, October 2026.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

Discovery of Post‐Translationally Modified Epitopes in Autoimmunity: Someone Has to Fish so Everyone Can Eat

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Post‐translational modifications (PTMs) chemically diversify the ~20,000 genomically encoded proteins into millions of functional variants, and this diversity has profound consequences for T cell‐mediated immune responses. PTM‐reactive T cells have been identified across numerous autoimmune diseases and, in several cases, implicated directly ...
Sanya Arshad, Benjamin M. Cameron, Alok V. Joglekar   +2 more
wiley   +1 more source

The Role of NFAT Family Transcription Factors in Diabetic Retinopathy

, 2015
Diabetic retinopathy (DR) is one of the leading causes of vision loss in working age populations. Clinically, DR is divided into early non-proliferative diabetic retinopathy (NPDR), characterized by retinal vascular inflammation, hyperpermeability, and ...
Bretz, Colin Andrew
core  

Building an Interleukin‐10‐Producing Identity: How B Cells Acquire Interleukin‐10 Competence and How Plasma Cell Differentiation Consolidates This Program

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Interleukin (IL)‐10‐producing B cells represent an archetype for the regulatory functions of B cells. Here, we review the cell‐surface receptors and transcriptional regulators that control IL‐10 expression in B cells and enable their regulatory function in vivo.
Bui Thi Cuc, Yanli Tong, Zhiguo Wu, Daniel Alvarez‐Simon, Simon Fillatreau   +4 more
wiley   +1 more source

Modulation of NFAT-5, an outlying member of the NFAT family, in human keratinocytes and skin.

American journal of translational research, 2011
Cyclosporin A (CsA) and tacrolimus block T cell activation by inhibiting the phosphatase calcineurin and preventing translocation from the cytoplasm to the nucleus of the transcription factor Nuclear Factor of Activated T cells (NFAT). NFAT compose a family of transcription factors that are turned on during T cell activation.To study the expression of ...
Wael I, Al-Daraji, John, Afolayan, Bettina G, Zelger, Adel, Abdellaoui, Bernhard, Zelger   +4 more
openaire   +1 more source

Gene regulatory elements determine efficacy of BCMA-targeted CAR-T cell products. [PDF]

J Immunother Cancer
Blumenberg V, June KB, Birocchi F, Escobar G, Graham C, Fan Y, Phillips MK, Park S, Harris D, Anderson H, Bouffard AA, Kelly C, Elsallab M, Berger TR, Gallagher KM, Leick MB, Mucci A, Maus MV.   +17 more
europepmc   +1 more source

NFATs and Alzheimer's Disease.

Molecular and cellular pharmacology
Nuclear factor of activated T cells (NFAT) is a transcription factor that translocates from cytosol to nucleus following dephosphorylation by the Ca(2+)/calmodulin dependent protein phosphatase calcineurin (CN). In nervous tissue, aberrant CN signaling is increasingly linked to a variety of pathologic features associated with Alzheimer's disease (AD ...
Hafiz Mohmmad, Abdul, Jennifer L, Furman, Michelle A, Sama, Diana M, Mathis, Christopher M, Norris   +4 more
openaire   +1 more source