Results 61 to 70 of about 32,558 (245)

NFAT Factors Are Dispensable for the Development but Are Critical for the Maintenance of Foxp3⁺ Regulatory T Cells

Cells, 2022
The transcription factors of the nuclear factor of activated T cell (NFAT) family play a crucial role in multiple aspects of T cell function. It has recently been reported that NFATs play an important role in the suppressive function of CD4+CD25+Foxp3 ...
Carlotta Barahona de Brito, Amiya Kumar Patra   +1 more
doaj   +1 more source

Transcriptional regulation by calcium, calcineurin, and NFAT [PDF]

Genes & Development, 2003
The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family member is NFAT5, the only NFATrelated protein represented in the Drosophila genome.
Patrick G, Hogan, Lin, Chen, Julie, Nardone, Anjana, Rao   +3 more
openaire   +2 more sources

ERK inhibition and 3D spheroids increased NFAT transactivation.

, 2014
HeyA8 cells plated at 50,000 cells in a 24 well plate for transfections. 500 ng of NFAT-Luc/Renilla mixture (40:1) were transfected per well and incubated overnight.
Keven Huang (675616), Christine Kiefer (675617), Adeela Kamal (675618)   +2 more
core   +1 more source

NFATc3 and VIP in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease.

PLoS ONE, 2017
Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are both debilitating lung diseases which can lead to hypoxemia and pulmonary hypertension (PH).
Anthony M Szema, Edward Forsyth, Benjamin Ying, Sayyed A Hamidi, John J Chen, Sonya Hwang, Jonathan C Li, Debra Sabatini Dwyer, Juan M Ramiro-Diaz, Wieslawa Giermakowska, Laura V Gonzalez Bosc   +10 more
doaj   +1 more source

NFAT Gene Family in Inflammation and Cancer [PDF]

Current Molecular Medicine, 2013
Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle ...
M-G, Pan, Y, Xiong, F, Chen
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

NFAT activation in PC12 cells with reduce PMCAs content.

, 2014
PC12 cells were transfected with plasmids encoding firefly luciferase under NFAT-dependent promoter (pGL3-NFAT-luc) and reference plasmids with Renilla luciferase (pRL-SV40).
Ludmila Zylinska (542407), Paulina Podszywalow-Bartnicka (573928), Michalina Kosiorek (542406), Slawomir Pikula (542409)   +3 more
core   +1 more source

NFAT single-deficient murine T cells reduce the risk of aGvHD while controlling cytomegalovirus infection

iScience
Summary: NFAT is a family of transcription factors whose activation is inhibited by calcineurin inhibitors (CNIs). In allogeneic hematopoietic stem cell transplantation (allo-HCT), CNIs are employed to prevent and treat graft-versus-host disease (GvHD ...
Nadine Hundhausen, Snigdha Majumder, Yin Xiao, Sigrun S. Haeusl, Helen Goehler, Rishav Seal, Cristina M. Chiarolla, Andreas Rosenwald, Matthias Eyrich, Luka Cicin-Sain, Friederike Berberich-Siebelt   +10 more
doaj   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

, 2006
SummaryAntigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of transcription factors and regulates T cell activation-associated
Ziegler, Steven F., Guo, L., Mathis, Diane, Bates, Darren L., Rao, Anjana, Lapan, A.D., Borde, M., Lapan, Ariya D., Borde, Madhuri, Mathis, D., Wu, Y., Stroud, J.C., Stroud, James C., Han, Aidong, Feuerer, M., Han, A., Feuerer, Markus, Bates, D.L., Chen, Lin, Heissmeyer, V., Ziegler, S.F., Rao, A., Wu, Yongqing, Benoist, Christophe, Chen, L., Heissmeyer, Vigo, Benoist, C., Guo, Liang   +27 more
core   +1 more source