Results 61 to 70 of about 78,892 (304)
Calcineurin Inhibitor Nephrotoxicity [PDF]
Clinical Journal of the American Society of Nephrology, 2009 The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome. However, the chronic nephrotoxicity of these drugs is the Achilles' heel of current immunosuppressive regimens.
Maarten, Naesens +2 more
openaire +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen +13 more
wiley +1 more source
Journal of Fungi, 2022 Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens.
Praveen R. Juvvadi +4 more
doaj +1 more source
Maximizing Neurovascular Outcomes of Facial Transplantation: A Comprehensive Review
Clinical Anatomy, EarlyView.ABSTRACT Facial transplantation is a division of reconstructive surgery which aims to improve the function and appearance of a face that has endured severe disfigurement. Currently, the face transplant procedure uses allogenic tissue, harvested from a brain‐dead donor, to replace damaged facial components.
Olivia A. James, Faye Bennett
wiley +1 more source
The Relationship of HSP-70 with Calcineurin, Sod and Catalase Post-Acute Myocardial Infarction in Wistar Rats Model [PDF]
Background: HSP-70 production increased following myocardial ischemia. HSP-70 helps to reduce infarct area through unclear mechanism. It appears that HSP-70 activates calcineurin and induce antioxidant enzymes such as superoxide dismutase (SOD) and ...
Maria Yolanda Probohoesodo, Maria +4 more
core +1 more source
Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden
ChemFoodChem, EarlyView.ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley +1 more source
, 2018 Figure S5. a The CCK-8 assays of LP-1 incubated with a range of [Ca2+]o concentrations. b and c Western blotting confirming the up-regulation and knockdown of TRPV2 channel in MM cells.
Juejin Wang (5863832) +7 more
core +1 more source
Stable and destabilized GFP reporters to monitor calcineurin activity in Saccharomyces cerevisiae
Microbial Cell, 2020 The protein phosphatase calcineurin is activated in response to rising intracellular Ca2+ levels and impacts fundamental cellular processes in organisms ranging from yeast to humans.
Jutta Diessl +4 more
doaj +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy [PDF]
, 2007 Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor.
Kellems, Rodney E. +19 more
core +1 more source