Results 81 to 90 of about 82,791 (297)
Frontiers in Microbiology, 2020 Talaromyces marneffei is a common cause of infection in immunocompromised patients in Southeast Asia and Southern China. The pathogenicity of T. marneffei depends on the ability of the fungus to survive the cytotoxic processes of the host immune system ...
Yan-Qing Zheng +8 more
doaj +1 more source
Dephosphorylation of Neuromodulin by Calcineurin
Journal of Biological Chemistry, 1989 Neuromodulin (p57, GAP-43, F1, B-50) is a major neural-specific, calmodulin binding protein found in brain, spinal cord, and retina that is associated with membranes. Phosphorylation of neuromodulin by protein kinase C causes a significant reduction in its affinity for calmodulin (Alexander, K. A., Cimler, B. M., Meirer, K. E., and Storm, D. R.
Y C, Liu, D R, Storm
openaire +2 more sources
Calcineurin in human heart hypertrophy. [PDF]
, 2002 peer reviewedBACKGROUND: In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be elevated in the myocardium of patients
Schuh, K. +23 more
core +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Posttransplant cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD) improves outcomes in recipients of HLA mismatched unrelated donor (MMUD) allogeneic hematopoietic cell transplantation (allo HCT). Outcomes of MMUD HCT using PTCy in patients requiring reduced intensity or non‐myeloablative conditioning (RIC/NMA) are not well ...
Brian C. Shaffer +38 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2017 Background & Aims: There is a pressing need to develop effective preventative therapies for postâendoscopic retrograde cholangiopancreatography pancreatitis (PEP).
Abrahim I. Orabi +14 more
doaj +1 more source
NMR identification of calcineurin B residues affected by binding of a calcineurin A peptide [PDF]
, 1995 Triple resonance 3D NMR methods have been used to study the interaction between calcineurin B and a peptide fragment of calcineurin A for which it has high affinity (KD ∼4 × 10−7 M).
Bax, Ad +11 more
core +1 more source
Frontiers in Cellular and Infection MicrobiologyAntifungal resistance and antifungal tolerance are two distinct terms that describe different cellular responses to drugs. Antifungal resistance describes the ability of a fungus to grow above the minimal inhibitory concentration (MIC) of a drug ...
Liangsheng Guo +6 more
doaj +1 more source
, 2019 Mycobacterium leprae, the causative agent of leprosy, is unique amongst human pathogens in its capacity to produce the virulence factor phenolic glycolipid (PGL)-I.
Florence Carreras (1806151) +11 more
core +1 more source
BiomoleculesTransient receptor potential melastatin-3 (TRPM3) channels are cation channels activated by heat and chemical ligands. TRPM3 regulates heat sensation, secretion, neurotransmitter release, iris constriction, and tumor promotion.
Gerald Thiel, Oliver G. Rössler
doaj +1 more source
Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus
, 2007 Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus.
Joseph Heitman +13 more
core +1 more source