Results 101 to 110 of about 82,791 (297)
British Journal of Clinical Pharmacology, EarlyView.Aims Almost 5% of pregnancies are affected by immune‐mediated inflammatory diseases (IMIDs). As treatments become available, understanding their use during pregnancy is important. We aimed to describe maternal, pregnancy and infant outcomes among IMID pregnancies exposed to biologic therapies. Methods Using the Merative™ MarketScan® Commercial Database,
Leah K. Flatman +3 more
wiley +1 more source
, 2014 Abnormal Ca2+-mediated signalling contributes to the pathogenesis of rheumatoid arthritis (RA). However, the potential implication of calcium channel blocker in RA remained unknown.
Lai, N-S.;Yu, C-L.;Yin, W-Y.;Yu, H-C.;Huang, H-B.;Tung, C-H.;Lu, M-C. +1 more
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, 2014 Scedosporium prolificans is a pathogenic mold resistant to current antifungals, and infection results in high mortality. Simultaneous targeting of both ergosterol biosynthesis and heat shock protein 90 (Hsp90) or the calcineurin pathway in S. prolificans
Dimitrios P. Kontoyiannis, Fazal Shirazi
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Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity [PDF]
, 2009 8 pages, 5 figures.-- PMID: 19189965 [PubMed].-- PMCID: PMC2666591.-- Supplementary information available at: http://www.jbc.org/content/suppl/2009/02/05/M805889200.DC1.htmlCalcineurin phosphatase plays a crucial role in T cell activation ...
Messeguer Peypoch, Ángel +8 more
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British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to evaluate the long‐term cost‐effectiveness of belatacept vs. tacrolimus as maintenance immunosuppression in adult kidney transplant recipients, focusing on the trade‐off between reduced new‐onset diabetes after transplantation (NODAT), immunological risk and potential renal benefit.
Salvatore Di Maria +2 more
wiley +1 more source
Calcineurin in a Crowded World
Biochemistry, 2016 Calcineurin is a Ser/Thr phosphatase that is important for key biological processes, including immune system activation. We previously identified a region in the intrinsically disordered regulatory domain of calcineurin that forms a critical amphipathic α-helix (the "distal helix") that is required for complete activation of calcineurin.
Cook, Erik C., Creamer, Trevor P.
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Biological Reviews, EarlyView.ABSTRACT During their long evolutionary history, land plants have evolved a range of adaptations to different abiotic stressors. These help explain present‐day diversity and distribution patterns, as well as the potential resilience of natural and agricultural systems to a changing climate. Most previous research has focused on adaptation to individual
Marc Fradera‐Soler +6 more
wiley +1 more source
Calcineurin in Animal Behavior
Molecules and Cells, 2004 The conserved Ca2+/calmodulin-dependent phosphatase calcineurin has been shown to be involved in numerous and diverse functions both at the cellular and organism level. Recent genetic and pharmacological studies in animals including C. elegans, Drosophila, Aplysia, rat and mice have also implicated calcineurin in behavior, particularly in the ...
Jin Il, Lee, Joohong, Ahnn
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More Evidence Supports the Association of Ppp3cc with Schizophrenia
, 2008 Calcineurin is a calcium/calmodulin-dependent protein phosphatase composed of two subunits; a regulatory subunit of calcineurin B (CNB), and a catalytic subunit of calcineurin A (CNA).
劉玉麗;范盛娟;劉智民;張倩青;楊偉志;洪舜郁;俞松良;黃宗正;謝明憲;劉震鐘;莊明敏;鄔哲源;陳為堅;胡海國 +1 more
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