Results 111 to 120 of about 82,791 (297)
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
CABIN1 펩타이드를 이용한 대체 calcineurin 억제제 개발 [PDF]
, 2022 학위논문(박사) -- 서울대학교대학원 : 융합과학기술대학원 분자의학 및 바이오제약학과, 2022. 8. 윤홍덕.The C-terminal fragment of calcineurin binding protein-1 (CABIN1) interacts with calcineurin and represses the transcriptional activity of nuclear factor of activated T cells (NFAT).
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ESC Heart Failure, Volume 12, Issue 2, Page 1166-1175, April 2025.A contemporary simple risk score for prediction of severe AKI after HT. Abstract Background The aim of this study was to develop a simple risk score to estimate severe acute kidney injury (AKI) risk based on a large contemporary heart transplantation (HT) cohort.
Shuangshuang Zhu +10 more
wiley +1 more source
Calcium-directed therapy in acute pancreatitis
Медицина неотложных состоянийBackground. Acute pancreatitis (AP) is a common and potentially life-threatening disease with high rates of complications and mortality. One of its key pathogenic mechanisms is disruption of calcium homeostasis in pancreatic acinar cells.
С.М. Чуклін, С.С. Чуклін
doaj +1 more source
Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Toxins, 2019 The calcineurin pathway is an important signaling cascade for growth, sexual development, stress response, and pathogenicity in fungi. In this study, we investigated the function of CrzA, a key transcription factor of the calcineurin pathway, in an ...
Su-Yeon Lim +5 more
doaj +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Untethered Electrical Stimulation Using Optoelectricity and Piezoelectricity for Tissue Regeneration
FlexTech, EarlyView.Untethered electrical stimulation from optoelectronic and piezoelectric materials can aid regeneration of damaged tissue. ABSTRACT Electrical signals are increasingly recognized as important regulators of tissue development and regeneration, with outcomes linked to behaviors including proliferation, differentiation, cell migration, and more.
Ryan Yao, Baochun Xu, Cunjiang Yu
wiley +1 more source
陆军军医大学学报Objective Calcineurin (CaN) is implicated in regulating hippocampal astrocytic excitatory amino acid transporter 1 (EAAT1) and 2 (EAAT2) expression. This study investigates whether tacrolimus (FK506) reduces epileptogenesis by upregulating EAAT1 and ...
CHEN Changling, YE Lan
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, 2018 The protein phosphatase calcineurin is central to Ca2+ signaling pathways from yeast to humans. Full activation of calcineurin requires Ca2+ binding to the regulatory subunit CNB, comprised of four Ca2+-binding EF hand domains, and recruitment of Ca2 ...
Kerri Waters +6 more
core +1 more source
Gut Medicine, EarlyView.ABSTRACT Postoperative ileus (POI) is a frequent complication after surgical procedures, predominantly manifesting as aberrant gastrointestinal motility, which markedly extends the duration of postoperative recovery for patients. The clinical duration of POI is typically modulated by intricate inflammatory cascades, with mast cells assuming a critical ...
Tian‐le Zhang +4 more
wiley +1 more source