Results 1 to 10 of about 101,738 (257)
Plant Signaling and Behavior, 2022 Calmodulin (CaM) and calmodulin-like (CML) genes are widely involved in plant growth and development and mediating plant stress tolerance. However, the whole genome scale studies about CaM and CML gene families have not been done in wheat, and the ...
Yanyi Li, Shuo Zhou
exaly +2 more sources
Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII. [PDF]
PLoS ONE, 2012 Activation of CaMKII by calmodulin and the subsequent maintenance of constitutive activity through autophosphorylation at threonine residue 286 (Thr286) are thought to play a major role in synaptic plasticity. One of the effects of autophosphorylation at
Melanie I Stefan +2 more
doaj +1 more source
Two distinct calmodulin binding sites in the third intracellular loop and carboxyl tail of angiotensin II (AT(1A)) receptor. [PDF]
PLoS ONE, 2013 In this study, we present data that support the presence of two distinct calmodulin binding sites within the angiotensin II receptor (AT(1A)), at juxtamembrane regions of the N-terminus of the third intracellular loop (i3, amino acids 214-231) and ...
Renwen Zhang +4 more
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Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation. [PDF]
PLoS ONE, 2012 Calcium entry and the subsequent activation of CaMKII trigger synaptic plasticity in many brain regions. The induction of long-term potentiation (LTP) in the CA1 region of the hippocampus requires a relatively high amount of calcium-calmodulin.
Ling Zhong, Nashaat Z Gerges
doaj +1 more source
Calmodulin binding proteins and neuroinflammation in multiple neurodegenerative diseases
BMC Neuroscience, 2022 Calcium dysregulation (“Calcium Hypothesis”) is an early and critical event in Alzheimer’s and other neurodegenerative diseases. Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred ...
Danton H. O’Day, Robert J. Huber
doaj +1 more source
Calmodulin adopts an extended conformation when interacting with L-selectin in membranes. [PDF]
PLoS ONE, 2013 Calmodulin, an intracellular calcium-binding protein, is thought to regulate ectodomain shedding of many membrane proteins, but the underlying molecular mechanism has remained unclear.
Wei Deng, John A Putkey, Renhao Li
doaj +1 more source
Calmodulin and Calmodulin Binding Proteins in Dictyostelium: A Primer [PDF]
International Journal of Molecular Sciences, 2020 Dictyostelium discoideum is gaining increasing attention as a model organism for the study of calcium binding and calmodulin function in basic biological events as well as human diseases. After a short overview of calcium-binding proteins, the structure of Dictyostelium calmodulin and the conformational changes effected by calcium ion binding to its ...
Danton H. O’Day +2 more
openaire +3 more sources
A change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activity. [PDF]
PLoS ONE, 2013 All subtypes of KCNQ channel subunits (KCNQ1-5) require calmodulin as a co-factor for functional channels. It has been demonstrated that calmodulin plays a critical role in KCNQ channel trafficking as well as calcium-mediated current modulation. However,
Anastasia Kosenko, Naoto Hoshi
doaj +1 more source
Biomolecules, 2022 Mutations in the calcium-sensing protein calmodulin (CaM) have been linked to two cardiac arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4), with varying degrees of severity ...
Matthew D. McCoy +3 more
doaj +1 more source
Calmodulin in a Heartbeat [PDF]
The FEBS Journal, 2013 Calmodulin is the primary sensor of intracellular calcium (Ca2+) levels in eukaryotic cells playing a key role in the proper deciphering of Ca2+ signalling. Given the versatility of Ca2+ as a secondary messenger, it is not surprising that calmodulin interacts with a vast number of proteins.
Sorensen, Anders B +2 more
openaire +3 more sources