Calmodulin binding proteins and neuroinflammation in multiple neurodegenerative diseases [PDF]
BMC Neuroscience, 2022 Calcium dysregulation (“Calcium Hypothesis”) is an early and critical event in Alzheimer’s and other neurodegenerative diseases. Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred ...
Danton H. O’Day, Robert J. Huber
doaj +2 more sources
Phytochemical Interactions with Calmodulin and Critical Calmodulin Binding Proteins Involved in Amyloidogenesis in Alzheimer’s Disease [PDF]
Biomolecules, 2023 An increasing number of plant-based herbal treatments, dietary supplements, medical foods and nutraceuticals and their component phytochemicals are used as alternative treatments to prevent or slow the onset and progression of Alzheimer’s disease.
Danton H. O'Day
doaj +2 more sources
Alzheimer’s Disease beyond Calcium Dysregulation: The Complex Interplay between Calmodulin, Calmodulin-Binding Proteins and Amyloid Beta from Disease Onset through Progression [PDF]
Current Issues in Molecular Biology, 2023 A multifactorial syndrome, Alzheimer’s disease is the main cause of dementia, but there is no existing therapy to prevent it or stop its progression. One of the earliest events of Alzheimer’s disease is the disruption of calcium homeostasis but that is ...
Danton H. O’Day
doaj +2 more sources
Microchip Electrophoresis Assay for Calmodulin Binding Proteins. [PDF]
J Sep Sci, 2021 AbstractThe calcium signaling protein calmodulin regulates numerous intracellular processes. We introduce a sensitive microchip assay to separate and detect calmodulin binding proteins. The assay utilizes an optimized microchip electrophoresis protein separation platform with laser‐induced fluorescence detection.
Samarasinghe TN, Zeng Y, Johnson CK.
europepmc +4 more sources
Calmodulin Binding Proteins and Alzheimer's Disease. [PDF]
J Alzheimers Dis, 2015 Abstract The small, calcium-sensor protein, calmodulin, is ubiquitously expressed and central to cell function in all cell types. Here the literature linking calmodulin to Alzheimer’s disease is reviewed. Several experimentally-verified calmodulin-binding proteins are involved in the formation of amyloid-β plaques including amyloid-β protein precursor,
O'Day DH, Eshak K, Myre MA.
europepmc +6 more sources
The predictive performance of short-linear motif features in the prediction of calmodulin-binding proteins [PDF]
BMC Bioinformatics, 2018 Background The prediction of calmodulin-binding (CaM-binding) proteins plays a very important role in the fields of biology and biochemistry, because the calmodulin protein binds and regulates a multitude of protein targets affecting different cellular ...
Yixun Li +5 more
doaj +2 more sources
Pull-down of calmodulin-binding proteins. [PDF]
J Vis Exp, 2012 Calcium (Ca(2+)) is an ion vital in regulating cellular function through a variety of mechanisms. Much of Ca(2+) signaling is mediated through the calcium-binding protein known as calmodulin (CaM). CaM is involved at multiple levels in almost all cellular processes, including apoptosis, metabolism, smooth muscle contraction, synaptic plasticity, nerve ...
Kaleka KS +3 more
europepmc +4 more sources
Structural Aspects and Prediction of Calmodulin-Binding Proteins. [PDF]
Int J Mol Sci, 2020 Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM’s ability to adapt to binding targets with different structures is related to the flexible central helix separating the N- and C ...
Andrews C, Xu Y, Kirberger M, Yang JJ.
europepmc +4 more sources
Calmodulin and Calmodulin Binding Proteins in Dictyostelium: A Primer. [PDF]
Int J Mol Sci, 2020 Dictyostelium discoideum is gaining increasing attention as a model organism for the study of calcium binding and calmodulin function in basic biological events as well as human diseases. After a short overview of calcium-binding proteins, the structure of Dictyostelium calmodulin and the conformational changes effected by calcium ion binding to its ...
O'Day DH, Taylor RJ, Myre MA.
europepmc +5 more sources
The Complex Interplay between Toxic Hallmark Proteins, Calmodulin-Binding Proteins, Ion Channels, and Receptors Involved in Calcium Dyshomeostasis in Neurodegeneration [PDF]
BiomoleculesCalcium dyshomeostasis is an early critical event in neurodegeneration as exemplified by Alzheimer’s (AD), Huntington’s (HD) and Parkinson’s (PD) diseases.
Danton H. O’Day
doaj +2 more sources