Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin. [PDF]
Int J Mol Sci, 2020 The integral role of calmodulin in the amyloid pathway and neurofibrillary tangle formation in Alzheimer’s disease was first established leading to the “Calmodulin Hypothesis”.
O'Day DH.
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Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegeneration [PDF]
Current Issues in Molecular Biology, 2022 Neurodegeneration leads to multiple early changes in cognitive, emotional, and social behaviours and ultimately progresses to dementia. The dysregulation of calcium is one of the earliest potentially initiating events in the development of ...
Danton H. O’Day
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BioTechniques, 1996 To identify calmodulin-binding proteins in cellular extracts and tissue homogenates and to analyze purified calmodulin target proteins, overlay procedures using 125I-calmodulin or, more recently, nonradioactive biotinylated calmodulin have been widely ...
Roland Fischer, Yu Wei, Martin Berchtold
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Calmodulin-Binding Protein Detection Using a Non-Radiolabeled Calmodulin Fusion Protein
BioTechniques, 2001 Calmodulin-binding proteins are involved in numerous cellular signaling pathways. The biotinylated-calmodulin overlay is a nonradioactive method widely used to detect calmodulin-binding proteins in tissue and cell samples.
Gloria Murray +3 more
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The Role of Calmodulin vs. Synaptotagmin in Exocytosis
Frontiers in Molecular Neuroscience, 2021 Exocytosis is a Ca2+-regulated process that requires the participation of Ca2+ sensors. In the 1980s, two classes of Ca2+-binding proteins were proposed as putative Ca2+ sensors: EF-hand protein calmodulin, and the C2 domain protein synaptotagmin. In the
Renhao Xue +8 more
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Calmodulin-binding proteins in bovine semen [PDF]
Reproduction, 1993 An 125I-labelled calmodulin gel overlay procedure was used to direct calmodulin-binding proteins in bovine spermatozoa and seminal plasma. Several calmodulin-binding proteins with molecular masses ranging from 12 to > 200 kDa were detected in epididymal and ejaculated spermatozoa.
P, Manjunath +3 more
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Next generation calmodulin affinity purification: Clickable calmodulin facilitates improved protein purification. [PDF]
PLoS ONE, 2018 As the proteomics field continues to expand, scientists are looking to integrate cross-disciplinary tools for studying protein structure, function, and interactions. Protein purification remains a key tool for many characterization studies.
Julia G Fraseur, Tamara L Kinzer-Ursem
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Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]
, 2008 BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Najl V Valeyev +19 more
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Phosphofructokinase is a calmodulin binding protein
FEBS Letters, 1983 A trial to purify myosin light chain kinase from crude myosin led to the isolation of a M r 85 000 calmodulin binding protein different from this enzyme. Because it showed inherent phosphofructokinase activity we investigated its relation to this enzyme.
Mayr, Georg W., Heilmeyer, Ludwig M.G.
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Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs [PDF]
, 2011 Calmodulin (CaM) is a highly conserved, ubiquitous, calcium-binding protein; it binds to and regulates many different protein targets, thereby functioning as a calcium sensor and signal transducer.
Lin, Tzu-Yung +17 more
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