Results 31 to 40 of about 77,245 (243)

Competitive tuning: Competition's role in setting the frequency-dependence of Ca2+-dependent proteins. [PDF]

PLoS Computational Biology, 2017
A number of neurological disorders arise from perturbations in biochemical signaling and protein complex formation within neurons. Normally, proteins form networks that when activated produce persistent changes in a synapse's molecular composition.
Daniel R Romano, Matthew C Pharris, Neal M Patel, Tamara L Kinzer-Ursem   +3 more
doaj   +1 more source

Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions.

PLoS Computational Biology, 2015
Calmodulin is a calcium-binding protein ubiquitous in eukaryotic cells, involved in numerous calcium-regulated biological phenomena, such as synaptic plasticity, muscle contraction, cell cycle, and circadian rhythms.
Massimo Lai, Denis Brun, Stuart J Edelstein, Nicolas Le Novère   +3 more
doaj   +1 more source

Neurogranin stimulates Ca2+/calmodulin-dependent kinase II by suppressing calcineurin activity at specific calcium spike frequencies.

PLoS Computational Biology, 2020
Calmodulin sits at the center of molecular mechanisms underlying learning and memory. Its complex and sometimes opposite influences, mediated via the binding to various proteins, are yet to be fully understood. Calcium/calmodulin-dependent protein kinase
Lu Li, Massimo Lai, Stephen Cole, Nicolas Le Novère, Stuart J Edelstein   +4 more
doaj   +1 more source

Modulation of calcium-binding proteins expression and cisplatin chemosensitivity by calcium chelation in human breast cancer MCF-7 cells

Heliyon, 2021
Cisplatin (CDDP) is currently one of the most effective FDA-approved treatments for breast cancer. Previous studies have shown that CDDP-induced cell death in human breast cancer (MCF-7) cells is associated with disruption of calcium homeostasis. However,
Rawad Hodeify, Shoib Sarwar Siddiqui, Rachel Matar, Cijo George Vazhappilly, Maxime Merheb, Hussain Al Zouabi, John Marton   +6 more
doaj   +1 more source

Scanning the human proteome for calmodulin-binding proteins [PDF]

Proceedings of the National Academy of Sciences, 2005
The calcium ion (Ca 2+ ) is a ubiquitous second messenger that is crucial for the regulation of a wide variety of cellular processes. The diverse transient signals transduced by Ca 2+ are mediated by intracellular Ca 2+
Xinchun, Shen, C Alexander, Valencia, Jack W, Szostak, Jack, Szostak, Biao, Dong, Rihe, Liu   +5 more
openaire   +2 more sources

NCS-1 associates with adenosine A2A receptors and modulates receptor function

Frontiers in Molecular Neuroscience, 2012
Modulation of G protein-coupled receptor (GPCR) signalling by local changes in intracellular calcium concentration is an established function of Calmodulin which is known to interact with many GPCRs. Less is known about the functional role of the closely
Gemma eNavarro, Johannes eHradsky, Carmen eLluis, Vicent eCasado, Peter J. McCormick, Michael R. Kreutz, Marina eMikhaylova   +6 more
doaj   +1 more source

A Modeling and Analysis Study Reveals That CaMKII in Synaptic Plasticity Is a Dominant Affecter in CaM Systems in a T286 Phosphorylation-Dependent Manner

Molecules, 2022
NMDAR-dependent synaptic plasticity in the hippocampus consists of two opposing forces: long-term potentiation (LTP), which strengthens synapses and long-term depression (LTD), which weakens synapses.
Hamish Stevens-Bullmore, Don Kulasiri, Sandhya Samarasinghe   +2 more
doaj   +1 more source

Regulation of calmodulin binding to P-57. A neurospecific calmodulin binding protein.

Journal of Biological Chemistry, 1987
P-57 is a neural-specific calmodulin binding protein with novel calmodulin binding properties. P-57 exhibits higher affinity for calmodulin-Sepharose in the absence of free Ca2+ than in the presence of Ca2+ (Andreasen, T.J., Luetje, C.W., Heideman, W. & Storm, D.R. (1983) Biochemistry 22, 4615-4618; Cimler, B.
K A, Alexander, B M, Cimler, K E, Meier, D R, Storm   +3 more
openaire   +2 more sources

Characterization of a Calmodulin-binding Transcription Factor from Strawberry (Fragaria × ananassa)

The Plant Genome, 2015
Calmodulin-binding transcription activator (CAMTA) is a calmodulin-binding transcription factor that has a broad range of functions from sensory mechanisms to regulating many growth and developmental processes. In this study, we isolated four strawberry
Xiangpeng Leng, Jian Han, Xiaomin Wang, Mizhen Zhao, Xin Sun, Chen Wang, Jinggui Fang   +6 more
doaj   +1 more source

Reciprocality Between Estrogen Biology and Calcium Signaling in the Cardiovascular System

Frontiers in Endocrinology, 2020
17β-Estradiol (E2) is the main estrogenic hormone in the body and exerts many cardiovascular protective effects. Via three receptors known to date, including estrogen receptors α (ERα) and β (ERβ) and the G protein-coupled estrogen receptor 1 (GPER, aka ...
Quang-Kim Tran
doaj   +1 more source