Results 21 to 30 of about 101,738 (257)
Oxidation of Methionine 77 in Calmodulin Alters Mouse Growth and Behavior
Antioxidants, 2018 Methionine 77 in calmodulin can be stereospecifically oxidized to methionine sulfoxide by mammalian methionine sulfoxide reductase A. Whether this has in vivo significance is unknown.
Méry Marimoutou +4 more
doaj +1 more source
Neurogranin Regulates Metaplasticity
Frontiers in Molecular Neuroscience, 2020 Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory.
Ling Zhong, Nashaat Z. Gerges
doaj +1 more source
Roles of calcium signaling in cancer metastasis to bone
Exploration of Targeted Anti-tumor Therapy, 2022 Bone metastasis is a frequent complication for cancers and an important reason for the mortality in cancer patients. After surviving in bone, cancer cells can cause severe pain, life-threatening hypercalcemia, pathologic fractures, spinal cord ...
Tianying Xie +7 more
doaj +1 more source
Identity of the particulate form of calmodulin with soluble calmodulin
FEBS Letters, 1981 Discovery of Ca2+activatable phosphodiesterase [l] and subsequent demonstration of protein modulator which confers Ca2+-sensitivity upon this enzyme [2,3] coincided with the discovery of a protein activator of brain phosphodiesterase [4]. However, it took several years before these two independent lines of the research merged when the identity of the ...
Sobue, Kenji +3 more
openaire +2 more sources
Frontiers in Oncology, 2023 IntroductionAn attractive, yet unrealized, goal in cancer therapy is repurposing psychiatric drugs that can readily penetrate the blood-brain barrier for the treatment of primary brain tumors and brain metastases.
Marion Vanneste +13 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Cloning and sequence analysis of two calmodulin isoform cDNA from mulberry
浙江大学学报. 农业与生命科学版, 2008 In order to elucidate the roles of calmodulin in mulberry stress-resistance, cDNA library of Fengchisang seedlings was constructed using SMART (switching mechanism at 5′ end of RNA transcript) cDNA library construction technology.
WANG Wei +4 more
doaj +1 more source
Cells, 2020 Exploring the interactions between the Ca2+ binding protein calmodulin (CaM) and its target proteins remains a challenging task. Members of the Munc13 protein family play an essential role in short-term synaptic plasticity, modulated via the interaction ...
Christine Piotrowski +8 more
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li +11 more
wiley +1 more source