Results 31 to 40 of about 131,283 (255)

Roles of calcium signaling in cancer metastasis to bone

Exploration of Targeted Anti-tumor Therapy, 2022
Bone metastasis is a frequent complication for cancers and an important reason for the mortality in cancer patients. After surviving in bone, cancer cells can cause severe pain, life-threatening hypercalcemia, pathologic fractures, spinal cord ...
Tianying Xie, Sitong Chen, Jiang Hao, Pengfei Wu, Xuelian Gu, Haifeng Wei, Zhenxi Li, Jianru Xiao   +7 more
doaj   +1 more source

CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signalling and learning [PDF]

, 2013
Calcium (Ca2+)/calmodulin (CaM)-dependent kinase II (CaMKII) activity plays a fundamental role in learning and memory. A key feature of CaMKII in memory formation is its ability to be regulated by autophosphorylation, which switches its activity on and ...
John M. Gillespie, Gillespie, John M, John Michael Gillespie, James J L Hodge, James J. L. Hodge, Hodge, James J L   +5 more
core   +1 more source

Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation [PDF]

, 2010
Weakly tetanized synapses in area CA1 of the hippocampus that ordinarily display long-term potentiation lasting ~3 h (called early-LTP) will maintain a longer-lasting change in efficacy (late-LTP) if the weak tetanization occurs shortly before or after ...
Okuno, Hiroyuki, Redondo, Roger L., Okuno, Hiroyukki, Dr., Spooner, Patrick A., Bito, Haruhiko, Morris, R. G. M. (Richard G. M.), Frenguelli, Bruno G., Morris, Richard G. M.   +7 more
core   +1 more source

The anti-cancer efficacy of a novel phenothiazine derivative is independent of dopamine and serotonin receptor inhibition

Frontiers in Oncology, 2023
IntroductionAn attractive, yet unrealized, goal in cancer therapy is repurposing psychiatric drugs that can readily penetrate the blood-brain barrier for the treatment of primary brain tumors and brain metastases.
Marion Vanneste, Marion Vanneste, Anita Venzke, Anita Venzke, Soumitra Guin, Andrew J. Fuller, Andrew J. Jezewski, Sarah R. Beattie, Damian J. Krysan, Damian J. Krysan, Damian J. Krysan, Marvin J. Meyers, Michael D. Henry, Michael D. Henry   +13 more
doaj   +1 more source

3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]

, 1983
: Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Weber, W., Treiman, M., Gratzl, Manfred
core   +1 more source

CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis [PDF]

, 2009
The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules.
Borth, Heike, Boekhoff, Ingrid, Ackermann, Frauke, Zitranski, Nele, Gudermann, Thomas, Buech, Thomas   +5 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Cloning and sequence analysis of two calmodulin isoform cDNA from mulberry

浙江大学学报. 农业与生命科学版, 2008
In order to elucidate the roles of calmodulin in mulberry stress-resistance, cDNA library of Fengchisang seedlings was constructed using SMART (switching mechanism at 5′ end of RNA transcript) cDNA library construction technology.
WANG Wei, WANG Xing-ke, WANG Sheng-peng, SHEN Xing-jia, ZHAO Wei-guo   +4 more
doaj   +1 more source

Delineating the Molecular Basis of the Calmodulin–bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry—Evidence for a Novel CaM Binding Motif in bMunc13-2

Cells, 2020
Exploring the interactions between the Ca2+ binding protein calmodulin (CaM) and its target proteins remains a challenging task. Members of the Munc13 protein family play an essential role in short-term synaptic plasticity, modulated via the interaction ...
Christine Piotrowski, Rocco Moretti, Christian H. Ihling, André Haedicke, Thomas Liepold, Noa Lipstein, Jens Meiler, Olaf Jahn, Andrea Sinz   +8 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source