Results 31 to 40 of about 122,133 (302)

Further Characterization of Dopamine Release by Permeabilized PC 12 Cells [PDF]

, 1987
Rat pheochromocytoma cells (PC 12) permeabilized with staphylococcal α-toxin release [3H]dopamine after addition of micromolar Ca2+. This does not require additional Mg2+-ATP (in contrast to bovine adrenal medullary chromaffin cells).
Ahnert-Hilger, G., Manfred Gratzl, Gratzl, Manfred, Gudrun Ahnert‐Hilger   +3 more
core   +1 more source

Oxidation of Methionine 77 in Calmodulin Alters Mouse Growth and Behavior

Antioxidants, 2018
Methionine 77 in calmodulin can be stereospecifically oxidized to methionine sulfoxide by mammalian methionine sulfoxide reductase A. Whether this has in vivo significance is unknown.
Méry Marimoutou, Danielle A. Springer, Chengyu Liu, Geumsoo Kim, Rodney L. Levine   +4 more
doaj   +1 more source

Human Calmodulin Mutations [PDF]

Frontiers in Molecular Neuroscience, 2018
Fluxes of calcium (Ca2+) across cell membranes enable fast cellular responses. Calmodulin (CaM) senses local changes in Ca2+ concentration and relays the information to numerous interaction partners. The critical role of accurate Ca2+ signaling on cellular function is underscored by the fact that there are three independent CaM genes (CALM1-3) in the ...
Jensen, Helene H, Brohus, Malene, Nyegaard, Mette, Overgaard, Michael T   +3 more
openaire   +5 more sources

Calmodulin-binding transcription factor shapes the male courtship song in Drosophila [PDF]

, 2019
Males of the Drosophila melanogaster mutant croaker (cro) generate a polycyclic pulse song dissimilar to the monocyclic songs typical of wild-type males during courtship. However, cro has not been molecularly mapped to any gene in the genome.
Daisuke Yamamoto (29442), Kosei Sato (7041635), Masayuki Koganezawa (2212585), Md. Tanveer Ahsan (7041638), Manabu Ote (5269691)   +4 more
core   +1 more source

Neurogranin Regulates Metaplasticity

Frontiers in Molecular Neuroscience, 2020
Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory.
Ling Zhong, Nashaat Z. Gerges
doaj   +1 more source

3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]

, 1983
: Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Weber, W., Treiman, M., Gratzl, Manfred
core   +1 more source

Roles of calcium signaling in cancer metastasis to bone

Exploration of Targeted Anti-tumor Therapy, 2022
Bone metastasis is a frequent complication for cancers and an important reason for the mortality in cancer patients. After surviving in bone, cancer cells can cause severe pain, life-threatening hypercalcemia, pathologic fractures, spinal cord ...
Tianying Xie, Sitong Chen, Jiang Hao, Pengfei Wu, Xuelian Gu, Haifeng Wei, Zhenxi Li, Jianru Xiao   +7 more
doaj   +1 more source

Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation [PDF]

, 2010
Weakly tetanized synapses in area CA1 of the hippocampus that ordinarily display long-term potentiation lasting ~3 h (called early-LTP) will maintain a longer-lasting change in efficacy (late-LTP) if the weak tetanization occurs shortly before or after ...
Okuno, Hiroyuki, Redondo, Roger L., Okuno, Hiroyukki, Dr., Spooner, Patrick A., Bito, Haruhiko, Morris, R. G. M. (Richard G. M.), Frenguelli, Bruno G., Morris, Richard G. M.   +7 more
core   +1 more source

Identity of the particulate form of calmodulin with soluble calmodulin

FEBS Letters, 1981
Discovery of Ca2+activatable phosphodiesterase [l] and subsequent demonstration of protein modulator which confers Ca2+-sensitivity upon this enzyme [2,3] coincided with the discovery of a protein activator of brain phosphodiesterase [4]. However, it took several years before these two independent lines of the research merged when the identity of the ...
Sobue, Kenji, Yamazaki, Reiko, Yasuda, Seiji, Kakiuchi, Shiro   +3 more
openaire   +2 more sources

The anti-cancer efficacy of a novel phenothiazine derivative is independent of dopamine and serotonin receptor inhibition

Frontiers in Oncology, 2023
IntroductionAn attractive, yet unrealized, goal in cancer therapy is repurposing psychiatric drugs that can readily penetrate the blood-brain barrier for the treatment of primary brain tumors and brain metastases.
Marion Vanneste, Marion Vanneste, Anita Venzke, Anita Venzke, Soumitra Guin, Andrew J. Fuller, Andrew J. Jezewski, Sarah R. Beattie, Damian J. Krysan, Damian J. Krysan, Damian J. Krysan, Marvin J. Meyers, Michael D. Henry, Michael D. Henry   +13 more
doaj   +1 more source