Results 11 to 20 of about 131,283 (255)

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]

, 2008
BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Najl V Valeyev, Nikolay V Kotov, Kotov, Nikolay, Bates D., Declan G. Heslop-Harrison (7606778), Heslop-Harrison, Pat, Postlethwaite, Ian, Declan G Bates, Najl V. Valeyev (7606775), Valeyev N., Ian Postlethwaite, Kotov N., Ian Postlethwaite (36312), Valeyev, Najil, Pat Heslop-Harrison, Nikolay V. Kotov (7606781), Bates, Declan, Heslop-Harrison P., Postlethwaite I., Declan G. Bates (2615086)   +19 more
core   +1 more source

Detection of Calmodulin-Binding Proteins Using a 32P-Labeled GST-Calmodulin Fusion Protein and a Novel Renaturation Protocol

BioTechniques, 1996
To identify calmodulin-binding proteins in cellular extracts and tissue homogenates and to analyze purified calmodulin target proteins, overlay procedures using 125I-calmodulin or, more recently, nonradioactive biotinylated calmodulin have been widely ...
Roland Fischer, Yu Wei, Martin Berchtold
doaj   +1 more source

Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro [PDF]

, 1992
To find out whether calmodulin activity could be a common denominator for the cellular control of renin secretion and synthesis, we have examined the effects of calmodulin antagonists on the secretion and the synthesis of renin in primary cultures of ...
Kurtz, Armin, Della Bruna, R., R. Della Bruna, Corvol, P., A. Kurtz, F. Pinet, P. Corvol, Pinet, F.   +7 more
core   +1 more source

Tilianin improves cognition in a vascular dementia rodent model by targeting miR-193b-3p/CaM- and miR-152-3p/CaMKIIα-mediated inflammatory and apoptotic pathways

Frontiers in Immunology, 2023
IntroductionAlthough vascular dementia (VaD) is the second most prevalent form of dementia, there is currently a lack of effective treatments. Tilianin, isolated from the traditional drug Dracocephalum moldavica L., may protect against ischemic injury by
Ting Sun, Linjie Tan, Mimin Liu, Li Zeng, Kaiyue Zhao, Zhongdi Cai, Shengnan Sun, Zhuorong Li, Rui Liu   +8 more
doaj   +1 more source

Relative affinity constants by electrospray ionization and Fourier transform ion cyclotron resonance mass spectrometry: calmodulin binding to peptide analogs of myosin light chain kinase [PDF]

, 2003
Synthetic RS20 peptide and a set of its point-mutated peptide analogs have been used to analyze the interactions between calmodulin (CaM) and the CaM-binding sequence of smooth-muscle myosin light chain kinase both in the presence and the absence of Ca2+.
Lafitte, Daniel, Vainiotalo, Pirjo, Nousiainen, Marjaana, Derrick, Peter J.   +3 more
core   +1 more source

Kv7 channels can function without constitutive calmodulin tethering.

PLoS ONE, 2011
M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding ...
Juan Camilo Gómez-Posada, Paloma Aivar, Araitz Alberdi, Alessandro Alaimo, Ainhoa Etxeberría, Juncal Fernández-Orth, Teresa Zamalloa, Meritxell Roura-Ferrer, Patricia Villace, Pilar Areso, Oscar Casis, Alvaro Villarroel   +11 more
doaj   +1 more source

Protein flexibility is key to cisplatin crosslinking in calmodulin [PDF]

, 2012
Chemical crosslinking in combination with Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) has significant potential for studying protein structures and proteinprotein interactions.
Römer, Rudolf A., Sadler, P. J., Zhao, Yao, (Researcher in chemistry), O'Connor, Peter B., Jimenez-Roldan, J. Emilio, Wells, Stephen A., Li, Huilin   +6 more
core   +1 more source

W342F Mutation in CCaMK Enhances Its Affinity to Calmodulin But Compromises Its Role in Supporting Root Nodule Symbiosis in Medicago truncatula

Frontiers in Plant Science, 2017
The calcium/calmodulin-dependent protein kinase (CCaMK) is regulated by free Ca2+ and Ca2+-loaded calmodulin. This dual binding is believed to be involved in its regulation and associated physiological functions, although direct experimental evidence for
Edgard Jauregui, Liqun Du, Liqun Du, Cynthia Gleason, B. W. Poovaiah   +4 more
doaj   +1 more source

Effect of Chronic Hydrogen Peroxide Exposure on Ion Transport in Gills of Common Carp (Cyprinus carpio)

Fishes, 2023
High environmental hydrogen peroxide (H2O2) has been demonstrated to be toxic for fish. However, the response mechanism of fish to chronic H2O2 exposure is not yet well understood.
Yating Mou, Bing Li, Yiran Hou, Rui Jia, Jian Zhu   +4 more
doaj   +1 more source

Interactions of Calmodulin With the Multiple Binding Sites of Cav1.2 Ca2+ Channels

Journal of Pharmacological Sciences, 2010
Although calmodulin binding to various sites of the Cav1.2 Ca2+ channel has been reported, the mechanism of the interaction is not fully understood. In this study we examined calmodulin binding to fragment channel peptides using a semi-quantitative pull ...
Hadhimulya Asmara, Etsuko Minobe, Zahangir A. Saud, Masaki Kameyama   +3 more
doaj   +1 more source