Results 121 to 130 of about 78,892 (304)
NMR identification of calcineurin B residues affected by binding of a calcineurin A peptide
, 1995 Triple resonance 3D NMR methods have been used to study the interaction between calcineurin B and a peptide fragment of calcineurin A for which it has high affinity (KD ∼4 × 10−7 M).
Bax, Ad +11 more
core +1 more source
An insight into new strategies to combat antifungal drug resistance
Drug Design, Development and Therapy, 2018 Yan-Hua Zheng,1 Yue-Yun Ma,2 Yi Ding,3 Xie-Qun Chen,1 Guang-Xun Gao1 1Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China; 2Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth ...
Zheng YH, Ma YY, Ding Y, Chen XQ, Gao GX
doaj
Rheumatology &Autoimmunity, EarlyView.Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura +3 more
wiley +1 more source
Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus
, 2011 Michael SticherlingHautklinik, Universitätsklinikum Erlangen (Clinic of Dermatology, University Hospitals of Erlangen), Erlangen, GermanyAbstract: Cutaneous manifestations of lupus erythematosus (CLE) are manifold, presenting with unspecific ...
Michael Sticherling
core +1 more source
The Journal of Dermatology, EarlyView.ABSTRACT Clinical phenotypes of atopic dermatitis (AD) can vary, with some individuals displaying difficult‐to‐treat prurigo nodularis‐like lesions. We aimed to assess the real‐world disease burden and treatment course of Japanese adults with AD‐associated prurigo nodules (AD‐Pn) receiving conventional AD treatments.
Yoko Kataoka +8 more
wiley +1 more source
Calcineurin as a Nociceptor Modulator
Pain Physician, 2009 Calcineurin may be involved in affecting nociceptive processes in multiple circumstances. It is conceivable that interfering with calcineurin’s normal role in contributing to glial resting membrane potential, via its effects on the ion channel (TRESK) [tandem-pore-domain weakly inward rectifying potassium channels (TWIK)-related spinal cord potassium ...
openaire +2 more sources
Demodex Infestation in Patients With Atopic Dermatitis Treated With Dupilumab: A Case–Control Study
The Journal of Dermatology, EarlyView.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease in which dupilumab, an interleukin‐4 receptor alpha antagonist, has become a cornerstone therapy for moderate‐to‐severe disease. However, persistent facial and neck erythema and related symptoms have been increasingly reported during dupilumab treatment, and the underlying ...
Pinar Dursun +2 more
wiley +1 more source
Australasian Journal of Dermatology, EarlyView.ABSTRACT Background/Objectives Dupilumab is an anti‐interleukin (IL)‐4 receptor (IL‐4Rα) monoclonal antibody used to manage atopic dermatitis (AD). There is a paucity of real‐world Australian data for dupilumab in paediatric AD, especially regarding differences in clinical profiles between age groups.
Paul Sun Woo Kim +7 more
wiley +1 more source
, 2009 8 pages, 5 figures.-- PMID: 19189965 [PubMed].-- PMCID: PMC2666591.-- Supplementary information available at: http://www.jbc.org/content/suppl/2009/02/05/M805889200.DC1.htmlCalcineurin phosphatase plays a crucial role in T cell activation ...
Messeguer Peypoch, Ángel +8 more
core +1 more source
BiomedicinesBackground: Tacrolimus is widely used as a first-line immunosuppressant in transplant immunology; however, its clinical application is constrained by the narrow therapeutic index and considerable interindividual variability.
Xinyi Zheng +5 more
doaj +1 more source