Results 121 to 130 of about 82,791 (297)

Neurotoxicity of Calcineurin Inhibitors

Annals of Indian Academy of Neurology
Abstract Cyclosporine and tacrolimus belong to the immunosuppressive drugs of the calcineurin inhibitors group. They are widely used in the treatment of patients after organ transplants. One of their complications is neurotoxicity, the mechanism of which is still not fully understood.
Bajon, Aleksander, Sikora, Jędrzej, Siwek, Michal, Wiecanowska, Julia, Miedziaszczyk, Miłosz, Idasiak-Piechocka, Ilona, Mania, Anna   +6 more
openaire   +2 more sources

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

An insight into new strategies to combat antifungal drug resistance

Drug Design, Development and Therapy, 2018
Yan-Hua Zheng,1 Yue-Yun Ma,2 Yi Ding,3 Xie-Qun Chen,1 Guang-Xun Gao1 1Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China; 2Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth ...
Zheng YH, Ma YY, Ding Y, Chen XQ, Gao GX
doaj  

Discrepant Urinary Findings Between Dipstick Protein and Sulfosalicylic Acid Test in a Patient With Hyaline Casts: A Case Report

Journal of Clinical Laboratory Analysis, EarlyView.
In this post‐transplant patient, increased hyaline casts with negative dipstick protein but positive SSA testing occurred during evolving acute kidney injury and resolved with renal recovery. This discordant urinalysis pattern may warrant confirmatory protein testing and correlation with serial renal function in patients at high risk of AKI.
Yifei Jia, Binquan Chu, Fengjun Chen, Xiangyu Zhu, Chen Hang, Xiaoling Yu, Jinpiao Lin   +6 more
wiley   +1 more source

Data_Sheet_3_CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy.PDF

, 2019
Mycobacterium leprae, the causative agent of leprosy, is unique amongst human pathogens in its capacity to produce the virulence factor phenolic glycolipid (PGL)-I.
Florence Carreras (1806151), Catherine Astarie-Dequeker (239240), Mathieu Epardaud (1806157), Jacques Prandi (3094236), Véronique Mayau (8131212), Wladimir Malaga (239246), Nathalie Winter (67462), Caroline Demangel (239243), Aude Remot (162483), Émilie Doz-Deblauwe (8131209), Ainhoa Arbues (138090), Christophe Guilhot (111596)   +11 more
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Data_Sheet_5_CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy.PDF

, 2019
Mycobacterium leprae, the causative agent of leprosy, is unique amongst human pathogens in its capacity to produce the virulence factor phenolic glycolipid (PGL)-I.
Florence Carreras (1806151), Catherine Astarie-Dequeker (239240), Mathieu Epardaud (1806157), Jacques Prandi (3094236), Véronique Mayau (8131212), Wladimir Malaga (239246), Nathalie Winter (67462), Caroline Demangel (239243), Aude Remot (162483), Émilie Doz-Deblauwe (8131209), Ainhoa Arbues (138090), Christophe Guilhot (111596)   +11 more
core   +1 more source

Endoscopic findings in patients with Shwachman–Diamond syndrome: A report from the North American Shwachman–Diamond syndrome registry

JPGN Reports, EarlyView.
Abstract Objectives Shwachman–Diamond syndrome (SDS) is an inherited bone marrow failure disorder, and its endoscopic phenotype is poorly defined. We sought to characterize endoscopic findings in patients with genetically confirmed SDS. Methods Retrospective registry study of 45 patients with biallelic Shwachman–Bodian–Diamond syndrome mutations and ...
Elizabeth Korn, Jane Koo, Diana Schwarz, Meghan Haney, Juan Putra, Jaeson Kim, Leah Cheng, Sarah Steltz, Lois Schwarz, Sara Loveless, Richard Cooper, Claire Dusa, Kasiani C. Myers, Akiko Shimamura, Andrew Wehrman, Amit S. Grover   +15 more
wiley   +1 more source

PPP3R1 Promoter Polymorphism (Allelic Variation) Affects Tacrolimus Treatment Efficacy by Modulating E2F6 Binding Affinity

Biomedicines
Background: Tacrolimus is widely used as a first-line immunosuppressant in transplant immunology; however, its clinical application is constrained by the narrow therapeutic index and considerable interindividual variability.
Xinyi Zheng, Shengying Qin, Mingkang Zhong, Qinxia Xu, Cong Huai, Xiaoyan Qiu   +5 more
doaj   +1 more source

Calcineurin goes to sleep

Proceedings of the National Academy of Sciences
The need for sleep is evolutionarily conserved across animals. During sleep, animals give up opportunities for food, water, and sex, and become more vulnerable to predation. Although we know why we eat, drink, or reproduce, we do not yet know why we sleep.
Michael Ye, Graham H. Diering
openaire   +2 more sources