Results 141 to 150 of about 82,791 (297)

Calcineurin inhibitor minimisation versus continuation of calcineurin inhibitor treatment for liver transplant recipients

open access: yes, 2012
The therapeutic success of liver transplantation has been largely attributable to the development of effective immunosuppressive treatment regimens. In particular, calcineurin inhibitors were essential in reducing acute rejection and improving early ...
Gluud, Christian   +4 more
core   +1 more source

Successful Treatment of Refractory Lichen Amyloidosus With Dupilumab

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Lichen amyloidosis (LA) is a chronic, pruritic dermatosis with papillary dermal amyloid deposition. Standard therapies often fail, and most reports of dupilumab in LA involve patients with concomitant atopic dermatitis. We report a 32‐year‐old man with refractory, non‐atopic LA who had failed topical corticosteroids, tacrolimus, phototherapy ...
Sohrab Elahwiesy   +5 more
wiley   +1 more source

Calcineurin-dependent 20E signaling pathway enhances attacin expression to prime the immunity of Helicoverpa armigera against Bacillus thuringiensis Cry1Ac toxin

open access: yes
Enhancing the insecticidal efficacy of Bacillus thuringiensis (Bt) toxins by suppressing the immune responses of target insects can simultaneously augment the effectiveness of Bt-based products and address the growing issue of resistance.
Xinming Yin (182865)   +9 more
core   +1 more source

Stress enhances expression of calcium‐binding proteins and NMDAR subunit genes in the rat hippocampus

open access: yesNeuroprotection
Backgrounds Oxidative stress impairs the function of calcium‐binding proteins and deregulates calcium signaling in living organisms. We have previously explored the overexpression of calcium‐binding protein genes in a reactive oxygen and nitrogen species‐
Aravind Parthasarathy   +8 more
doaj   +1 more source

Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus

open access: yes, 2011
Michael SticherlingHautklinik, Universitätsklinikum Erlangen (Clinic of Dermatology, University Hospitals of Erlangen), Erlangen, GermanyAbstract: Cutaneous manifestations of lupus erythematosus (CLE) are manifold, presenting with unspecific ...
Michael Sticherling
core   +1 more source

Nail Lichen Planus in Children ‐ Epidemiology, Pathogenesis, Clinical Presentation, and Treatment

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Nail lichen planus (NLP) is a chronic inflammatory disorder that, while rare in children compared to adults, represents a significant cause of pediatric nail dystrophy that requires early recognition to prevent permanent scarring and nail loss.
Francesca Pampaloni, Matilde Iorizzo
wiley   +1 more source

Plasma Cell Mucositis: A 20‐Year Retrospective Review at a Tertiary Center

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Plasma cell mucositis (PCM) is a rare, chronic inflammatory condition of mucosal surfaces that is likely underdiagnosed and underreported, with limited data on its clinical characteristics, extracavitary involvement, and treatment outcomes.
Miguel A. Aristizabal‐Torres   +4 more
wiley   +1 more source

When Treatment Meets Natural History: Understanding Early Dermatitis‐Related Adverse Events in Systemic Atopic Dermatitis Trials

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Biologics and Janus kinase (JAK) inhibitors have transformed the management of atopic dermatitis (AD), yet some patients experience early worsening of disease activity during treatment initiation. In clinical trials, these events are typically recorded as treatment‐emergent adverse events (TEAEs), most commonly coded as “atopic dermatitis”. We
Diego Ruiz Dasilva   +17 more
wiley   +1 more source

A Practical Guide for Incorporating Emollients in the Treatment of Mild‐to‐Moderate Atopic Dermatitis

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Emollients and cleansers are essential components in managing atopic dermatitis (AD). While international evidence‐based guidelines recommend using gentle cleansers and emollients daily as a foundational therapy for AD, implementation in practice remains suboptimal.
Mette Deleuran   +12 more
wiley   +1 more source

The Proximity of the Lesion to Cell Bodies Determines the Free Radical Risk Induced in Rat Rubrospinal Neurons Subjected to Axonal Injury

open access: yes, 2009
To find out whether close axonal injury resulted in greater free radical risk to cord-projection central neurons than distant ones, we studied the expressions of nitric oxide synthase, calcineurin, and superoxide dismutase in rat rubrospinal neurons ...
曾國藩   +1 more
core  

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