Results 141 to 150 of about 78,892 (304)
, 2018 Tianyi Xia, Sang Zhu, Yan Wen, Shouhong Gao, Mingming Li, Xia Tao, Feng Zhang, Wansheng Chen Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China Background: Nephrotoxicity of ...
Wen Y +7 more
core
Pathogenesis of calcineurin inhibitor-induced hypertension
, 2012 This article reviews the current understanding of the mechanisms of calcineurin inhibitor-induced hypertension. Already early after the introduction of cyclosporine in the 1980s, vasoconstriction, sympathetic excitation and sodium retention by the kidney
Hoorn, Ewout +12 more
core +1 more source
Neurotoxicity of Calcineurin Inhibitors
Annals of Indian Academy of NeurologyAbstract Cyclosporine and tacrolimus belong to the immunosuppressive drugs of the calcineurin inhibitors group. They are widely used in the treatment of patients after organ transplants. One of their complications is neurotoxicity, the mechanism of which is still not fully understood.
Bajon, Aleksander +6 more
openaire +2 more sources
, 2007 The aim of the study was to identify main regulators of mitochondrial biogenesis in a skeletal muscle differentiation model. To investigate candidate factors we used the cytochrome c promoter as a representative promoter since cytochrome c levels ...
Frankó, András
core
SERCA2a inhibits calcineurin/NFAT pathway.
, 2013 The effect of SERCA2a on calcineurin and NFATc1 expression (A) was evaluated by Western blotting in neonatal myocytes non-infected (Cont) or infected with Ad.SERCA2a in the presence (+) or absence (−) of ET-1.
Roger J. Hajjar (142214) +8 more
core +1 more source
NeuroprotectionBackgrounds Oxidative stress impairs the function of calcium‐binding proteins and deregulates calcium signaling in living organisms. We have previously explored the overexpression of calcium‐binding protein genes in a reactive oxygen and nitrogen species‐
Aravind Parthasarathy +8 more
doaj +1 more source
The Top Five Advances in Solid Organ Transplantation in the Past Fifty Years
World Journal of Surgery, EarlyView.
Stephen J. Wigmore, Diana A. Wu
wiley +1 more source
Emerging Paediatric Uses of Dupilumab Beyond Approvals
Clinical &Experimental Allergy, EarlyView.Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese +11 more
wiley +1 more source
Reversibility of Adverse, Calcineurin-Dependent Cardiac Remodeling
, 2011 Rationale: Studies to dissect the role of calcineurin in pathological cardiac remodeling have relied heavily on murine models, in which genetic gain- and loss-of-function manipulations are initiated at
Jeff M. Berry +11 more
core +1 more source
Contact Dermatitis, EarlyView.ABSTRACT The present guideline updates the initial ESCD patch testing guideline, summarizing all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed‐type hypersensitivity skin and mucosal conditions. Sections with brief descriptions
Wolfgang Uter +23 more
wiley +1 more source