Results 91 to 100 of about 78,892 (304)
Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security
Journal of the Science of Food and Agriculture, EarlyView.Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori +9 more
wiley +1 more source
Allograft Survival with Calcineurin Inhibitors
, 2008 The immunosuppressive drugs cyclosporine A (CsA) and tacrolimus (FK506), also called calcineurin inhibitors, have truly revolutionized allograft transplantation.
Esther Voegelin +3 more
core +1 more source
Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling
Frontiers in Cell and Developmental BiologyThe activation of IP3 receptor (IP3R) Ca2+ channels generates agonist-mediated Ca2+ signals that are critical for the regulation of a wide range of biological processes. It is therefore surprising that CRISPR induced loss of all three IP3R isoforms (TKO)
Michael Young +5 more
doaj +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Background Traditional first‐line topical treatments for plaque psoriasis, particularly corticosteroids and vitamin D analogs, frequently have only limited efficacy for long‐term use, and present difficulties with safety and adherence. Objectives In this systematic review and meta‐analysis of randomized controlled trials (RCTs), we assessed ...
Aimal A. Khattak +11 more
wiley +1 more source
Vergleichende Charakterisierung der humanen Calcineurin-Isoformen [PDF]
, 2009 Calcineurin, eine Calcium/Calmodulin-abhängige Serin/Threonin-Proteinphosphatase, ist in wichtige Signalübertragungswege involviert, welche die Entwicklung und Funktion von Immun-, Nerven-, Kardiovaskular- und Muskelskelettsystemen steuern.
Kilka, Susann
core +1 more source
JAK Inhibitors in Psoriatic–Atopic Dermatitis Overlap: A Four‑Case Series
JEADV Clinical Practice, EarlyView.ABSTRACT Overlap between psoriasis and atopic dermatitis (AD) poses diagnostic and therapeutic challenges; monoclonal antibodies targeting a single axis may improve one component while worsening the other [1]. Janus kinase (JAK) inhibitors act pleiotropically and may provide simultaneous control of psoriatic and eczematous inflammation [2].
Eleonora Bongiovanni +6 more
wiley +1 more source
Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling
, 2012 In hippocampal neurons, the scaffold protein AKAP79 recruits the phosphatase calcineurin to L-type Ca2+ channels and couples Ca2+ influx to activation of calcineurin and of its substrate, the transcription factor NFAT.
Alexander Stein +11 more
core +2 more sources
Calcineurin in a Crowded World
Biochemistry, 2016 Calcineurin is a Ser/Thr phosphatase that is important for key biological processes, including immune system activation. We previously identified a region in the intrinsically disordered regulatory domain of calcineurin that forms a critical amphipathic α-helix (the "distal helix") that is required for complete activation of calcineurin.
Cook, Erik C., Creamer, Trevor P.
openaire +2 more sources
JEADV Clinical Practice, EarlyView.Abstract Background In moderate‐to‐severe psoriasis, residual lesions can be defined as “psoriasis lesions that persist despite well‐managed treatment, and which do not necessarily justify intensification or a change in treatment.” Residual lesions are accepted by guidelines and clinical trials.
Emmanuel Mahé +4 more
wiley +1 more source