Results 71 to 80 of about 82,791 (297)

The Relationship of HSP-70 with Calcineurin, Sod and Catalase Post-Acute Myocardial Infarction in Wistar Rats Model [PDF]

Background: HSP-70 production increased following myocardial ischemia. HSP-70 helps to reduce infarct area through unclear mechanism. It appears that HSP-70 activates calcineurin and induce antioxidant enzymes such as superoxide dismutase (SOD) and ...
Maria Yolanda Probohoesodo, Maria, Cornelia Ghea, Cornelia, Suhartono Taat Putra, Suhartono, Johanes Nugroho Eko Putranto, Johanes, Christo Darius, Christo   +4 more
core   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Calcineurin Inhibitor Nephrotoxicity [PDF]

Clinical Journal of the American Society of Nephrology, 2009
The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome. However, the chronic nephrotoxicity of these drugs is the Achilles' heel of current immunosuppressive regimens.
Maarten, Naesens, Dirk R J, Kuypers, Minnie, Sarwal   +2 more
openaire   +2 more sources

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Pharmacology of calcineurin antagonists

Transplantation Proceedings, 2004
Cyclosporine and tacrolimus share the same pharmacodynamic property of activated T-cell suppression via inhibition of calcineurin. The introduction of these drugs to the immunosuppressive repertoire of transplant management has greatly improved the outcomes in organ transplantation and constitutes arguably one of the major breakthroughs in modern ...
Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida, USA ( host institution ), Kapturczak, M.H, Meier-Kriesche, H.U, Kaplan, B   +3 more
openaire   +3 more sources

Calcineurin-NFAT signaling pathway.

Calcium-mediated signaling is involved in the activation of diverse subsets of gene transcription, including GZMB. Target gene expression can change with the activation of transcriptional factors in response to electrical stimulation, thus providing a ...
Minseon Lee (18404208), Soonjo Kwon (2584957)   +1 more
core   +1 more source

Additional file 6: of TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma

, 2018
Figure S5. a The CCK-8 assays of LP-1 incubated with a range of [Ca2+]o concentrations. b and c Western blotting confirming the up-regulation and knockdown of TRPV2 channel in MM cells.
Juejin Wang (5863832), Lijuan Chen (150349), Xiupan Lu (5863829), Qing Yan (72879), Hua Bai (145775), Jianyong Li (133044), Huayuan Zhu (5863823), Xuxing Shen (5863826)   +7 more
core   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source

The role of AMPK and CREB-1 in the regulation of mitochondrial biogenesis during muscle differentiation [PDF]

, 2007
The aim of the study was to identify main regulators of mitochondrial biogenesis in a skeletal muscle differentiation model. To investigate candidate factors we used the cytochrome c promoter as a representative promoter since cytochrome c levels ...
Frankó, András
core   +1 more source

The Expression of Can and Camk is Associated with Lipogenesis in the Muscle of Chicken

Brazilian Journal of Poultry Science, 2015
Intramuscular fat (IMF) content in chickens significantly contributes to meat quality. The main objective of this study was to assess the expression of calcineurin (CaN) and Ca2+/calmodulin-dependent protein kinase (CaMK) in lipogenesis in chicken muscle.
Y Yang, J Song, R Fu, Y Sun, J Wen
doaj   +1 more source