Results 71 to 80 of about 78,892 (304)
ESC Heart Failure, Volume 12, Issue 2, Page 1166-1175, April 2025.A contemporary simple risk score for prediction of severe AKI after HT. Abstract Background The aim of this study was to develop a simple risk score to estimate severe acute kidney injury (AKI) risk based on a large contemporary heart transplantation (HT) cohort.
Shuangshuang Zhu +10 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Calcineurin-NFAT signaling pathway.
Calcium-mediated signaling is involved in the activation of diverse subsets of gene transcription, including GZMB. Target gene expression can change with the activation of transcriptional factors in response to electrical stimulation, thus providing a ...
Minseon Lee (18404208) +1 more
core +1 more source
Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus
, 2007 Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus.
Joseph Heitman +13 more
core +1 more source
The Expression of Can and Camk is Associated with Lipogenesis in the Muscle of Chicken
Brazilian Journal of Poultry Science, 2015 Intramuscular fat (IMF) content in chickens significantly contributes to meat quality. The main objective of this study was to assess the expression of calcineurin (CaN) and Ca2+/calmodulin-dependent protein kinase (CaMK) in lipogenesis in chicken muscle.
Y Yang, J Song, R Fu, Y Sun, J Wen
doaj +1 more source
Tumor Biology, 2020 Maintaining intracellular pH is crucial for preserving healthy cellular behavior and, when dysregulated, results in increased proliferation, migration, and invasion.
Wayne Taylor Cottle +6 more
doaj +1 more source
Dephosphorylation of Neuromodulin by Calcineurin
Journal of Biological Chemistry, 1989 Neuromodulin (p57, GAP-43, F1, B-50) is a major neural-specific, calmodulin binding protein found in brain, spinal cord, and retina that is associated with membranes. Phosphorylation of neuromodulin by protein kinase C causes a significant reduction in its affinity for calmodulin (Alexander, K. A., Cimler, B. M., Meirer, K. E., and Storm, D. R.
Y C, Liu, D R, Storm
openaire +2 more sources
Inhibition of Calcineurin Phosphatase Activity by a Calcineurin B Homologous Protein [PDF]
Journal of Biological Chemistry, 1999 Calcineurin, a Ca(2+)/calmodulin-stimulated protein phosphatase, plays a key role in T-cell activation by regulating the activity of NFAT (nuclear factor of activated T cells), a family of transcription factors required for the synthesis of several cytokine genes.
X, Lin +3 more
openaire +2 more sources
Epilepsia, EarlyView.Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier +82 more
wiley +1 more source
iMeta, EarlyView.Climate change demands accelerated plant adaptation and de novo domestication. Yet current enviromics focuses disproportionately on external environments, neglecting internal dynamics—gene expression, metabolic flux, and signal transduction—within predictive envirotyping frameworks.
Lin‐An Zhang +8 more
wiley +1 more source