Results 11 to 20 of about 78,892 (304)
Cell Communication and Signaling, 2020 The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates.
Trevor P. Creamer
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Inhibition of calcineurin by cyclosporin A‐cyclophilin requires calcineurin B [PDF]
FEBS Letters, 1992 The interaction of the immunosuppressive complex cyclosporin A‐cyclophilin (CsA‐CyP) with the Ca2+/calmodulin‐dependent protein phosphatase calcineurin is investigated using a recombinant form of the A subunit of calcineurin (rCNA). Only in the presence of purified calcineurin B (CNB) does rCNA show the response of native calcineurin, i.e.
Haddy, Alice +3 more
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Calcineurin: Form and Function
Physiological Reviews, 2000 Calcineurin is a eukaryotic Ca2+- and calmodulin-dependent serine/threonine protein phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A, which contains an active site dinuclear metal center, and a tightly associated, myristoylated, Ca2+-binding subunit, calcineurin B.
F, Rusnak, P, Mertz
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, 2016 Calcineurin is a Ser/Thr phosphatase whose function is implicated in critical physiological processes such as immune system activation, fetal heart development, and long-term depression in neurons. Calcineurin has been implicated in the progression of Alzheimer’s disease and cardiac hypertrophy. It is not well understood how calcineurin is activated on
Cook, Erik C.
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The Role of NFATC4 Gene in Human Cutaneous Squamous Cell Carcinoma
Indian Journal of Dermatology, 2023 Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4) has been implicated in keratinocyte development and several types of cancer. A well-defined role for NFATC4 in cutaneous squamous cell carcinoma (CSCC) has not yet been established.
Fengjuan Li, Hongquan Chen, Xiaoou Lu
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AKAP79 enables calcineurin to directly suppress protein kinase A activity
eLife, 2021 Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA).
Timothy W Church +7 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases.
Ping Wang +9 more
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mBio, 2020 Mucormycosis is an emerging lethal fungal infection in immunocompromised patients. Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to understand genetics in Mucorales.
Sandeep Vellanki +7 more
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Pharmaceuticals, 2023 Histone deacetylase (HDAC) has been found to play a crucial role in the regulation of osteoclast differentiation and formation. This study was designed to identify the effect of the HDAC6 inhibitor CKD-WID on the receptor for the activation of nuclear ...
Seong-Kyu Kim +3 more
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Cells, 2023 GPR55 is involved in many physiological and pathological processes. In cancer, GPR55 has been described to show accelerating and decelerating effects in tumor progression resulting from distinct intracellular signaling pathways.
Marc Richard Kolbe +8 more
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