Results 11 to 20 of about 717,412 (277)

Hsp21 potentiates antifungal drug tolerance in Candida albicans. [PDF]

PLoS ONE, 2013
Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low number of available antifungal drugs.
François L Mayer, Duncan Wilson, Bernhard Hube   +2 more
doaj   +7 more sources

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal [PDF]

Microorganisms, 2020
Candida albicans represents the most frequent isolated yeast from bloodstream infections. Despite the remarkable progress in diagnostic and therapeutic approaches, these infections continue to be a critical challenge in intensive care units worldwide ...
Sofia Costa-de-Oliveira, Acácio G. Rodrigues   +1 more
doaj   +4 more sources

Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens [PDF]

Current Opinion in Microbiology
Fungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also ...
Judith Berman
exaly   +4 more sources

Mitochondria and fungal pathogenesis: Drug tolerance, virulence, and potential for antifungal therapy [PDF]

Eukaryotic Cell, 2011
Recently, mitochondria have been identified as an important contributor to virulence and drug tolerance of human fungal pathogens. In different scenarios, either hypo or hyper-virulence can result from changes to mitochondrial function.
Shingu-Vazquez, Miguel, Traven, Ana, Ana Traven, Miguel Shingu-Vazquez   +3 more
core   +4 more sources

The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress.

PLoS Pathogens, 2023
Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an ...
Ka Pui Sharon Yau, Harshini Weerasinghe, Francios A B Olivier, Tricia L Lo, David R Powell, Barbara Koch, Traude H Beilharz, Ana Traven   +7 more
doaj   +2 more sources

Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in Candida albicans [PDF]

Frontiers in Microbiology
BackgroundThe emergence of tolerance to antifungal agents in Candida albicans complicates the treatment of fungal infections. Understanding the mechanisms underlying this tolerance is crucial for developing effective therapeutic strategies.ObjectiveThis ...
Lijun Zheng, Yi Xu, Chen Wang, Liangsheng Guo   +3 more
doaj   +2 more sources

The role of Candida albicans stress response pathways in antifungal tolerance and resistance. [PDF]

iScience, 2022
Human fungal pathogens are the causative agents of devastating diseases across the globe, and the increasing prevalence of drug resistance threatens to undermine the already limited treatment options. One prominent pathogen is the opportunistic fungus Candida albicans, which can cause both superficial and serious systemic infections in ...
Iyer KR, Robbins N, Cowen LE.
europepmc   +4 more sources

Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes.

PLoS Pathogens, 2014
The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis, causing infections ranging from superficial to life-threatening disseminated disease. The inherent tolerance of C.
Tobias Schwarzmüller, Biao Ma, Ekkehard Hiller, Fabian Istel, Michael Tscherner, Sascha Brunke, Lauren Ames, Arnaud Firon, Brian Green, Vitor Cabral, Marina Marcet-Houben, Ilse D Jacobsen, Jessica Quintin, Katja Seider, Ingrid Frohner, Walter Glaser, Helmut Jungwirth, Sophie Bachellier-Bassi, Murielle Chauvel, Ute Zeidler, Dominique Ferrandon, Toni Gabaldón, Bernhard Hube, Christophe d'Enfert, Steffen Rupp, Brendan Cormack, Ken Haynes, Karl Kuchler   +27 more
doaj   +2 more sources

Cinnamic Acid Analogs as Intervention Catalysts for Overcoming Antifungal Tolerance. [PDF]

Molecules, 2017
Disruption of fungal cell wall should be an effective intervention strategy. However, the cell wall-disrupting echinocandin drugs, such as caspofungin (CAS), cannot exterminate filamentous fungal pathogens during treatment. For potency improvement of cell wall-disrupting agents (CAS, octyl gallate (OG)), antifungal efficacy of thirty-three cinnamic ...
Kim JH, Chan KL, Cheng LW.
europepmc   +5 more sources

Quantifying and Mitigating Antifungal Tolerance in the Pathogenic Yeast Candida auris [PDF]

Candida auris is an emerging pathogen that has been detected on five continents and is linked to resistance against the main three classes of antifungal drugs used to treat invasive infections, leading to healthcare-associated outbreaks. Tolerance refers
Rasouli Koohi, Samira
core   +2 more sources