Hsp21 potentiates antifungal drug tolerance in Candida albicans. [PDF]
PLoS ONE, 2013 Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low number of available antifungal drugs.
François L Mayer +2 more
doaj +7 more sources
Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal [PDF]
Microorganisms, 2020 Candida albicans represents the most frequent isolated yeast from bloodstream infections. Despite the remarkable progress in diagnostic and therapeutic approaches, these infections continue to be a critical challenge in intensive care units worldwide ...
Sofia Costa-de-Oliveira +1 more
doaj +4 more sources
Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens [PDF]
Current Opinion in MicrobiologyFungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also ...
Judith Berman
exaly +4 more sources
Cinnamic Acid Analogs as Intervention Catalysts for Overcoming Antifungal Tolerance. [PDF]
Molecules, 2017 Disruption of fungal cell wall should be an effective intervention strategy. However, the cell wall-disrupting echinocandin drugs, such as caspofungin (CAS), cannot exterminate filamentous fungal pathogens during treatment.
Kim JH, Chan KL, Cheng LW.
europepmc +6 more sources
The Rim Pathway Mediates Antifungal Tolerance in Candida albicans through Newly Identified Rim101 Transcriptional Targets, Including Hsp90 and Ipt1 [PDF]
Antimicrobial Agents and Chemotherapy, 2018 International audienceInvasive candidiasis (IC) is a major cause of morbidity and mortality despite antifungal treatment. Azoles and echinocandins are used as first-line therapiesfor IC.
Cecile Garnaud +2 more
exaly +3 more sources
PLoS Pathogens, 2023 Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an ...
Ka Pui Sharon Yau +7 more
doaj +2 more sources
Mitochondria and fungal pathogenesis: Drug tolerance, virulence, and potential for antifungal therapy [PDF]
Eukaryotic Cell, 2011 Recently, mitochondria have been identified as an important contributor to virulence and drug tolerance of human fungal pathogens. In different scenarios, either hypo or hyper-virulence can result from changes to mitochondrial function.
Shingu-Vazquez, Miguel +3 more
core +4 more sources
Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. [PDF]
PLoS Pathogens, 2014 The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis, causing infections ranging from superficial to life-threatening disseminated disease. The inherent tolerance of C.
Tobias Schwarzmüller +27 more
doaj +4 more sources
Candida parapsilosis sensu stricto Antifungal Resistance Mechanisms and Associated Epidemiology [PDF]
Journal of Fungi, 2023 Fungal diseases cause millions of deaths per year worldwide. Antifungal resistance has become a matter of great concern in public health. In recent years rates of non-albicans species have risen dramatically.
Iacopo Franconi +4 more
doaj +2 more sources
Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus
Frontiers in Microbiology, 2018 Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized structures present in nails, skin, and hair, causing superficial infections known as dermatophytosis.
Nilce M. Martinez-Rossi +8 more
doaj +2 more sources