Results 11 to 20 of about 5,632 (146)

With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in Cryptococcus neoformans [PDF]

mBio
Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells ...
Kyungyoon Yoo, Somanon Bhattacharya, Natalia Kronbauer Oliveira, Nivea Pereira de Sa, Gabriel Soares Matos, Maurizio Del Poeta, Bettina C. Fries   +6 more
doaj   +4 more sources

Candida albicans  Genotyping and Relationship of Virulence Factors with Fluconazole Tolerance in Infected Pediatric Patients. [PDF]

Infect Drug Resist, 2022
Candida albicans of different genotypes is a common cause of fungal infection in pediatric setting. This cross sectional study was designed to investigate ABC genotypes and the relationship between virulence factors and fluconazole tolerance among C. albicans isolates from infected pediatric patients.C.
Mashaly GE, Zeid MS.
europepmc   +4 more sources

Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance

Microorganisms, 2023
Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few ...
Xiaoping Ma, Wanling Yang, Aining Yang, Dong Chen, Chengdong Wang, Shanshan Ling, Sanjie Cao, Zhicai Zuo, Ya Wang, Zhijun Zhong, Guangneng Peng, Ming He, Yu Gu   +12 more
doaj   +3 more sources

The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>. [PDF]

Antimicrob Agents Chemother
ABSTRACT The incidence of non- albicans Candida infections has witnessed a substantial rise in recent decades. Candida glabrata (Nakaseomyces glabratus ), an opportunistic human fungal pathogen, is accountable for both superficial mucosal and life-
Zhu Q, Wijnants S, Feil R, Van Genechten W, Vergauwen R, Van Goethem O, Lunn JE, Van Ende M, Van Dijck P.   +8 more
europepmc   +4 more sources

A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

mBio, 2023
Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy
Hui Lu, Wanqian Li, Malcolm Whiteway, Hongkang Wang, Shuo Zhu, Zhe Ji, Yanru Feng, Lan Yan, Ting Fang, Liping Li, Tingjunhong Ni, Xiaolong Zhang, Quanzhen Lv, Zichao Ding, Lijuan Qiu, Dazhi Zhang, Yuanying Jiang   +16 more
doaj   +3 more sources

Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast [PDF]

EMBO Reports
Gim3 is an evolutionarily conserved component of the prefoldin chaperone complex, involved in protein folding. We previously found that GIM3 genetically interacts with many de novo mutations in Saccharomyces cerevisiae.
Mohammed T Tawfeeq, Dimitrios Konstantinidis, Ana Lucia Rocha Iraizos, Wouter Van Genechten, Jolien Vreys, Lieselotte Vermeersch, Karin Voordeckers, Patrick Van Dijck, Kevin J Verstrepen   +8 more
doaj   +2 more sources

Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age. [PDF]

Sci Rep, 2019
AbstractCandida auris is an emerging multi-drug resistant yeast that causes systemic infections. Here we show that C. auris undergoes replicative aging (RA) that results from asymmetric cell division and causes phenotypic differences between mother and daughter cells similar to other pathogenic yeasts. Importantly, older C. auris cells (10 generations)
Bhattacharya S, Holowka T, Orner EP, Fries BC.   +3 more
europepmc   +4 more sources

Selection of ethanol tolerant strains of Candida albicans by repeated ethanol exposure results in strains with reduced susceptibility to fluconazole.

PLoS ONE, 2023
Candida albicans is a commensal yeast that has important impacts on host metabolism and immune function, and can establish life-threatening infections in immunocompromised individuals. Previously, C.
Andrew W Day, Carol A Kumamoto
doaj   +4 more sources

Generalized Bullous Fixed Drug Eruption to Fluconazole with Positive Patch Testing and Confirmed Tolerance to Itraconazole

Iranian Journal of Allergy, Asthma and Immunology, 2021
Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical ...
Michael Makris, Christos Fokoloros, Anna Syrmali, Zoi Tsakiraki, Vasileia Damaskou, Evangelia Papadavid   +5 more
doaj   +4 more sources

Determinants of fluconazole resistance and echinocandin tolerance in C. parapsilosis isolates causing a large clonal candidemia outbreak among COVID-19 patients in a Brazilian ICU

Emerging Microbes and Infections, 2022
Patients presenting with severe COVID-19 are predisposed to acquire secondary fungal infections such as COVID-19-associated candidemia (CAC), which are associated with poor clinical outcomes despite antifungal treatment.
Farnaz Daneshnia, João N. de Almeida Júnior, Amir Arastehfar, Lisa Lombardi, Erika Shor, Lis Moreno, Ana Verena Mendes, Maria Goreth Barberino, Danilo Thomaz Yamamoto, Geraldine Butler, David S. Perlin, Arnaldo Lopes Colombo   +11 more
doaj   +3 more sources