Results 11 to 20 of about 5,860 (175)

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C.
Yi Xu, Hua Quan, Hua Quan, Yan Wang, Hua Zhong, Jun Sun, Jianjiang Xu, Nuan Jia, Yuanying Jiang   +8 more
doaj   +6 more sources

Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance

Microorganisms, 2023
Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few ...
Xiaoping Ma, Wanling Yang, Aining Yang, Dong Chen, Chengdong Wang, Shanshan Ling, Sanjie Cao, Zhicai Zuo, Ya Wang, Zhijun Zhong, Guangneng Peng, Ming He, Yu Gu   +12 more
doaj   +4 more sources

Parallel evolution of fluconazole resistance and tolerance in Candida glabrata

Frontiers in Cellular and Infection Microbiology
IntroductionWith the growing population of immunocompromised individuals, opportunistic fungal pathogens pose a global health threat. Candida species, particularly C. albicans and non-albicans Candida species such as C.
Lijun Zheng, Yi Xu, Chen Wang, Yubo Dong, Liangsheng Guo   +4 more
doaj   +5 more sources

Generalized Bullous Fixed Drug Eruption to Fluconazole with Positive Patch Testing and Confirmed Tolerance to Itraconazole

Iranian Journal of Allergy, Asthma and Immunology, 2021
Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical ...
Michael Makris, Christos Fokoloros, Anna Syrmali, Zoi Tsakiraki, Vasileia Damaskou, Evangelia Papadavid   +5 more
doaj   +5 more sources

The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>. [PDF]

Antimicrob Agents Chemother
The incidence of non-albicans Candida infections has witnessed a substantial rise in recent decades. Candida glabrata (Nakaseomyces glabratus), an opportunistic human fungal pathogen, is accountable for both superficial mucosal and life-threatening ...
Zhu Q, Wijnants S, Feil R, Van Genechten W, Vergauwen R, Van Goethem O, Lunn JE, Van Ende M, Van Dijck P.   +8 more
europepmc   +5 more sources

The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress.

PLoS Pathogens, 2023
Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an ...
Ka Pui Sharon Yau, Harshini Weerasinghe, Francios A B Olivier, Tricia L Lo, David R Powell, Barbara Koch, Traude H Beilharz, Ana Traven   +7 more
doaj   +2 more sources

Additivity interactions between fluconazole and citrus essential oils to Aspergillus fumigatus

Journal of Pre-Clinical and Clinical Research, 2021
Introduction Aspergillus fumigatus is the most common pathogen causing allergic bronchopulmonary mycosis. The pathogenic capacity of Aspergillus fumigatus is related to its thermal tolerance and the small size of the ...
Paula Wróblewska-Łuczka, Jarogniew Łuszczki   +1 more
doaj   +2 more sources

Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance. [PDF]

PLoS One
Development of resistance and tolerance to antifungal drugs in Candida albicans can compromise treatment of infections caused by this pathogenic yeast species. The uniquely expanded C.
O'Connor-Moneley J, Fletcher J, Bean C, Parker J, Kelly SL, Moran GP, Sullivan DJ.   +6 more
europepmc   +9 more sources

Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes

mBio, 2023
Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature ...
Feng Yang, Eduardo F. C. Scopel, Hao Li, Liu-liu Sun, Nora Kawar, Yong-bing Cao, Yuan-Ying Jiang, Judith Berman   +7 more
doaj   +2 more sources

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans [PDF]

mSphere, 2017
Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans.
Tobias Weil, Rodrigo Santamaría, Wanseon Lee, Johan Rung, Noemi Tocci, Darren Abbey, Ana R. Bezerra, Laura Carreto, Gabriela R. Moura, Mónica Bayés, Ivo G. Gut, Attila Csikasz-Nagy, Duccio Cavalieri, Judith Berman, Manuel A. S. Santos   +14 more
doaj   +4 more sources