Results 11 to 20 of about 605,588 (181)

Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance

Microorganisms, 2023
Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few ...
Xiaoping Ma, Wanling Yang, Aining Yang, Dong Chen, Chengdong Wang, Shanshan Ling, Sanjie Cao, Zhicai Zuo, Ya Wang, Zhijun Zhong, Guangneng Peng, Ming He, Yu Gu   +12 more
doaj   +4 more sources

Generalized Bullous Fixed Drug Eruption to Fluconazole with Positive Patch Testing and Confirmed Tolerance to Itraconazole

Iranian Journal of Allergy, Asthma and Immunology, 2021
Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical ...
Michael Makris, Christos Fokoloros, Anna Syrmali, Zoi Tsakiraki, Vasileia Damaskou, Evangelia Papadavid   +5 more
doaj   +6 more sources

With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in Cryptococcus neoformans [PDF]

mBio
Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells ...
Kyungyoon Yoo, Somanon Bhattacharya, Natalia Kronbauer Oliveira, Nivea Pereira de Sa, Gabriel Soares Matos, Maurizio Del Poeta, Bettina C. Fries   +6 more
doaj   +4 more sources

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C.
Yi Xu, Hua Quan, Hua Quan, Yan Wang, Hua Zhong, Jun Sun, Jianjiang Xu, Nuan Jia, Yuanying Jiang   +8 more
doaj   +4 more sources

Understanding fluconazole tolerance in Candida albicans: implications for effective treatment of candidiasis and combating invasive fungal infections

Journal of Global Antimicrobial Resistance, 2023
: Objectives: Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal ...
Yanru Feng, Hui Lu, Malcolm Whiteway, Yuanying Jiang   +3 more
doaj   +4 more sources

The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>. [PDF]

Antimicrob Agents Chemother
ABSTRACT The incidence of non- albicans Candida infections has witnessed a substantial rise in recent decades. Candida glabrata (Nakaseomyces glabratus ), an opportunistic human fungal pathogen, is accountable for both superficial mucosal and life-
Zhu Q, Wijnants S, Feil R, Van Genechten W, Vergauwen R, Van Goethem O, Lunn JE, Van Ende M, Van Dijck P.   +8 more
europepmc   +5 more sources

Parallel evolution of fluconazole resistance and tolerance in Candida glabrata

Frontiers in Cellular and Infection Microbiology
IntroductionWith the growing population of immunocompromised individuals, opportunistic fungal pathogens pose a global health threat. Candida species, particularly C. albicans and non-albicans Candida species such as C.
Lijun Zheng, Yi Xu, Chen Wang, Yubo Dong, Liangsheng Guo   +4 more
doaj   +3 more sources

Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast [PDF]

EMBO Reports
Gim3 is an evolutionarily conserved component of the prefoldin chaperone complex, involved in protein folding. We previously found that GIM3 genetically interacts with many de novo mutations in Saccharomyces cerevisiae.
Mohammed T Tawfeeq, Dimitrios Konstantinidis, Ana Lucia Rocha Iraizos, Wouter Van Genechten, Jolien Vreys, Lieselotte Vermeersch, Karin Voordeckers, Patrick Van Dijck, Kevin J Verstrepen   +8 more
doaj   +2 more sources

Determinants of fluconazole resistance and echinocandin tolerance in C. parapsilosis isolates causing a large clonal candidemia outbreak among COVID-19 patients in a Brazilian ICU

Emerging Microbes and Infections, 2022
Patients presenting with severe COVID-19 are predisposed to acquire secondary fungal infections such as COVID-19-associated candidemia (CAC), which are associated with poor clinical outcomes despite antifungal treatment.
Danilo Yamamoto Thomaz, Lisa Lombardi, João N de Almeida   +2 more
exaly   +3 more sources

Parameters affecting the reliable measurement of fluconazole tolerance using disk diffusion assays with Candida albicans

Microbiology Spectrum
Disk diffusion assays (DDAs) are widely used to determine antimicrobial susceptibility, which is measured as the size of the zone of inhibition (ZOI) after 24 h of growth, and is inversely proportional to the minimal inhibitory concentration (MIC).
Nora Kawar, Judith Berman
doaj   +2 more sources