Results 91 to 100 of about 14,439 (221)

Liver cancer multiomics reveals diverse protein kinase A disruptions convergently produce fibrolamellar hepatocellular carcinoma

Nature Communications
Fibrolamellar Hepatocellular Carcinoma (FLC) is a rare liver cancer characterized by a fusion oncokinase of the genes DNAJB1 and PRKACA, the catalytic subunit of protein kinase A (PKA).
David Requena, Jack A. Medico, Luis F. Soto-Ugaldi, Mahsa Shirani, James A. Saltsman, Michael S. Torbenson, Philip Coffino, Sanford M. Simon   +7 more
doaj   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, Volume 101, Issue 9, Page 2197-2213, September 2026.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Relevance of Kappa and Lambda Free Light Chains in Autoimmune Astrocytopathy Associated With Anti‐GFAP Antibodies

Annals of Clinical and Translational Neurology
Introduction The kappa‐free light chain (κ‐FLC) index is known to be highly sensitive and specific for diagnosing multiple sclerosis (MS), while little is understood about lambda (λ)‐FLC.
Michael Levraut, Romain Marignier, Mikael Cohen, Jeanne Benoit, Cassandre Landes‐Chateau, Elisabeth Maillart, Marion Cremoni, Barbara Seitz‐Polski, Anne‐Laurie Pinto, Pauline Dumez, Jérôme Honnorat, Christine Lebrun‐Frenay   +11 more
doaj   +1 more source

Early Serum Free Light Chain Response in Newly Diagnosed Multiple Myeloma: Documented Earlier Than MRD and Complementary in Prognosis

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Minimal residual disease (MRD) is the standard for deep response assessment in multiple myeloma but requires bone marrow sampling. Whether early serum free light chain (sFLC) response provides independent prognostic information in real‐world, predominantly non‐transplant patients remains unclear.
Yubiao Pan, Yue Wang, Yaqin Xiong, Panpan Li, Chenqi Yu, Peng Liu   +5 more
wiley   +1 more source

Genetic dissection of southern corn leaf blight resistance in sweet corn through genome‐wide association studies and genomic selection

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Southern corn leaf blight (SCLB) is caused by the fungal pathogen Bipolaris maydis (syn. Cochliobolus heterostrophus Drechsler) and is a common disease of fall crops of sweet corn. Phenotyping for SCLB resistance is performed through visual scoring, which is subjective and may limit genetic gain for this quantitative trait.
Darlon V. Lantican, Juan M. Gonzalez, Marco Antonio Peixoto, Kristen A. Leach, Larissa Carvalho Ferreira, Vitor A. Silva de Moura, Katia V. Xavier, Peter Balint‐Kurti, William Tracy, Marcio F. R. Resende Jr.   +9 more
wiley   +1 more source

Revisiting the foundation era of plant genomics with a commentary on the pioneering contributions of Prof. Chittaranjan Kole

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract The evolution of plant genomics has been shaped by several pioneering milestones, beginning with the introduction of restriction fragment length polymorphism–based genetic linkage maps in the mid‐1980s. Among the global contributors, Prof. Chittaranjan Kole stands as a distinguished figure whose work fundamentally shifted the trajectory of ...
Madhugiri Nageswara‐Rao, Sarita Pandey, Poulami Bhattacharjee, Dinesh Kumar Saini, Jaya R. Soneji, Bashasab Fakrudin, Lohithaswa Hirenallur Chandappa, Amir Ali Khoddamzadeh, Daniel A. Tucker, Jinfa Zhang, Shamseldeen Eltaher, Jauhar Ali, Robert Henry, Ilga Mercedes Porth, Aleksandra Radanović, Kiyosumi Hori, Maria Stefanie Dwiyanti, Ferdinando Branca, Shalini Tiwari, Matthew Blair, Yong Pyo Lim, Renate Horn, Olga Danilevskaya, Sunita Adhikari   +23 more
wiley   +1 more source

The association between naloxone distribution, buprenorphine treatment and retention and incident high‐risk opioid prescribing with opioid overdose death in Kentucky, Massachusetts, New York and Ohio, United States: An exploratory community‐level cohort study of data from the HEALing Communities Study

Addiction, Volume 121, Issue 9, Page 2482-2493, September 2026.
Abstract Aim We evaluated whether community‐level naloxone distribution, medication for opioid use disorder treatment and retention and incident high‐risk opioid prescribing rates were associated with opioid overdose death rates. Design Observational cohort conducted using 2019 to 2023 community‐level data as an exploratory analysis of the HEALing ...
Alexander Y. Walley, Debbie M. Cheng, Nathan Vandergrift, Marc Larochelle, JaNae Holloway, Jennifer L. Brown, Redonna Chandler, Laura C. Fanucchi, Daniel J. Feaster, Patricia R. Freeman, Timothy Hunt, Michelle R. Lofwall, Hannah K. Knudsen, Edward V. Nunes, Emmanuel Oga, Douglas R. Oyler, Jeffrey H. Samet, Jennifer Villani, Sharon L. Walsh, T. John Winhusen   +19 more
wiley   +1 more source

The molecular regulation of axillary bud fate determination and outgrowth into branch crown in strawberry involves BRC1

New Phytologist, Volume 251, Issue 5, Page 3021-3038, September 2026.
Proposed regulatory model for the axillary bud (AXB) fate determination of outgrowth into stolon and branch crown (BC) in strawberry. Summary In strawberry, the axillary bud (AXB) can produce either an elongated stem called stolon giving a daughter‐plant (asexual reproduction) or an inflorescence‐bearing branch crown (BC; sexual reproduction).
Marie Alonso, Pierre Prévost, Aline Potier, Pascal GP Martin, Yves Caraglio, Michael Nicolas, Michel Hernould, Christophe Rothan, Béatrice Denoyes, Amèlia Gaston   +9 more
wiley   +1 more source

Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Antioxidants
Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it.
Wanqian Li, Yanru Feng, Zhe Feng, Li Wang, Malcolm Whiteway, Hui Lu, Yuanying Jiang   +6 more
doaj   +1 more source

The SVP–FRO6 Module Integrates the Control of Leaf Senescence and Flowering in Arabidopsis

Plant, Cell &Environment, Volume 49, Issue 9, Page 7191-7209, September 2026.
ABSTRACT Plants coordinate major developmental transitions by integrating intrinsic genetic programs with environmental signals, where nutrient availability serves as a critical external factor shaping growth and fitness. Iron (Fe), an essential micronutrient for cellular respiration and photosynthesis, is strictly regulated through sophisticated ...
Hyunsu Park, Yeong Seon Yoon, Sanghoon Park, Ukcheol Jeong, Hyeyoung Choi, Hyunwoo Oh, Dovran Shamamedov, Zhonghai Li, Hye Ryun Woo   +8 more
wiley   +1 more source