Results 111 to 120 of about 14,439 (221)

Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice

open access: yesAging Cell, Volume 25, Issue 8, August 2026.
Targeting of RANKL by genetic and pharmacological approaches ameliorates key features of the progeroid phenotype in Zmpste24−/− mice. RANKL intervention restores bone mass, improves muscle phenotype, and extends survival. These findings support further exploration of RANKL‐targeted therapies for Hutchinson‐Gilford progeria syndrome.
Sandra Freitas‐Rodríguez   +11 more
wiley   +1 more source

Towards an integrated molecular understanding of plant hormones

open access: yesJournal of Integrative Plant Biology, Volume 68, Issue 8, Page 2787-2826, August 2026.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain   +2 more
wiley   +1 more source

In Situ GWAS in Two Range‐Edge Populations of European Beech (Fagus sylvatica L.) Identify Genetic Factors of Adaptation to Climate Change

open access: yesMolecular Ecology, Volume 35, Issue 15, August 2026.
ABSTRACT In forest tree populations, the timing of budbreak (TBB) depends on several factors, both environmental and genetic. The genomic architecture underlying this trait is still not fully characterized. So far, common garden experiments have highlighted a few genomic regions with little heritability, while the whole spectrum of TBB variation ...
Lauren Clément   +23 more
wiley   +1 more source

The GSK3/SHAGGY‐like OsGSK3 phosphorylates and inhibits phase separation of OsFCA at Ser‐43 and Ser‐45 to regulate brassinosteroid signaling and rice architecture

open access: yesNew Phytologist, Volume 251, Issue 4, Page 1909-1929, August 2026.
A working model for GLYCOGEN SYNTHASE KINASE 3‐mediated phosphorylation of FLOWERING CONTROL LOCUS A in the regulation of brassinosteroid signaling and rice growth and development. Summary Brassinosteroid (BR) signaling plays a critical role in rice (Oryza sativa L.) grain development.
Jiaqi Zhang   +14 more
wiley   +1 more source

Locally adapted Arabidopsis thaliana accessions show transcriptomic plasticity in a multi‐timescale analysis of whole‐genome gene expression in a natural environment

open access: yesPlant Biology, Volume 28, Issue 5, Page 1641-1656, August 2026.
Natural Arabidopsis thaliana accessions showed remarkable plasticity in both life‐cycle phenology and whole‐genome gene expression patterns in in natura field experiments. Nevertheless, local adaptation in fitness‐related life‐history traits can also be detected at the whole‐genome gene expression level.
A. Martínez‐Pérez   +8 more
wiley   +1 more source

Mitigating Teclistamab Toxicity: Prophylactic Tocilizumab and Timing of Immunoglobulin Replacement Therapy in a Nationwide Cohort

open access: yes
American Journal of Hematology, Volume 101, Issue 8, Page 2081-2085, August 2026.
Astrid Hundebøll Torpe   +14 more
wiley   +1 more source

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