Results 101 to 110 of about 13,651 (209)

Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. [PDF]

, 2015
AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation.
Chandrasekharan, KH, Fraser, JA, Guzadhur, L, Huang, CL-H, Jafferji, DIG, King, JH, Matthews, HR, Salvage, SC   +7 more
core   +2 more sources

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

Machine Learning‐Based Prediction of Drug‐Induced QTc Changes in a Large Finnish Biobank Cohort

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Prolongation of the QT interval is a known precursor to serious arrhythmias and sudden cardiac death, often triggered by medication use. Current medication risk evaluation platforms rely on literature‐based synthesis and may lag behind real‐world developments.
Ville Langén, Aleksi Winstén, Konsta Teppo, Timo Pohjonen, Jari Laukkanen, Arto Mannermaa, Teemu J. Niiranen, Joonatan Palmu   +7 more
wiley   +1 more source

Pulsed Field Ablation for Atrial Fibrillation in Patients With Obesity: Procedural and Clinical Outcomes

Pacing and Clinical Electrophysiology, Volume 49, Issue 5, Page 636-643, May 2026.
ABSTRACT Background Procedural and clinical outcomes in patients with obesity undergoing catheter ablation for atrial fibrillation (AF) have been mixed. Clinical data in the context of pulsed field ablation (PFA) are currently limited in this patient cohort.
Francis J. Ha, Duron Prinsloo, Edwin Xu, Hui Chen Han, Nitesh Nerlekar, Adam J. Brown, Emily Kotschet   +6 more
wiley   +1 more source

Acute Management of Paroxysmal Atrial Fibrillation with Intravenous Flecainide plus Oral Beta-Blockers

International Journal of Translational Medicine
Background: Intravenous (IV) flecainide is recommended for the pharmacological cardioversion of recent-onset atrial fibrillation (AF). The aim of this study was to study the efficacy and safety of IV flecainide, co-administered with oral b-blockers, for ...
Athanasios Kartalis, Dimitrios Afendoulis, Petros Voutas, Maria Moutafi, Nikolaos Papagiannis, Stefanos Garoufalis, Nikolaos Kartalis, Nikolaos Smyrnioudis, Antonios Ziakas, Matthaios Didagelos   +9 more
doaj   +1 more source

Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population [PDF]

, 2012
Background People with epilepsy are at increased risk for sudden death. The most prevalent cause of sudden death in the general population is sudden cardiac arrest (SCA) due to ventricular fibrillation (VF). SCA may contribute to the increased incidence
Bardai, A, Berdowski, J, Blom, MT, Brouwer, HJ, Koster, RW, Lamberts, RJ, Sander, JW, Spanjaart, AM, Tan, HL, Thijs, RD, van der Staal, SR   +10 more
core   +1 more source

Delayed diagnosis of Brugada syndrome in a patient with aborted sudden cardiac death and initial negative flecainide challenge

Clinical Case Reports, 2017
Key Clinical Message A negative flecainide challenge does not rule out Brugada syndrome even in the presence of nonfatal cardiac arrest as the first manifestation of the disease.
Samuel Chauveau, Olivier Le Vavasseur, Philippe Chevalier   +2 more
doaj   +1 more source

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia [PDF]

, 2016
Bannister, ML, George, CH, MacLeod, KT, Maxwell, C, Mukherjee, S, Sikkel, MB, Thomas, NL, Williams, AJ   +7 more
core   +1 more source

Prenatal diagnosis and postnatal follow-up of congenitally corrected transposition of the great arteries and recurrent supraventricular tachycardia [PDF]

, 2013
The prenatal sonographic diagnosis of congenitally corrected transposition of the great arteries (ccTGA), a rare form of congenital heart disease is very difficult.
Celik, I., Erdem, Sukru, Hallioglu, O., Kibar, Ayse E.   +3 more
core   +1 more source

Results of a Survey “Ethacizine evaluation for acute and chronic treatment of atrial fibrillation in real practice: Ukrainian national survey (ETERNITY)”

Сучасні медичні технології
The aim of the study: based on a survey of physicians, the study aims to identify the real clinical practices regarding the use of class IC antiarrhythmic drugs in Ukraine, particularly ethacizine, for restoring sinus rhythm in paroxysmal and persistent ...
N. M. Sydorova, M. Yu. Kolesnyk
doaj   +1 more source