Results 81 to 90 of about 13,651 (209)

Conversion of supraventricular arrhythmias to sinus rhythm using flecainide [PDF]

, 2017
We evaluated the efficacy of flecainide acetate (given intravenously to a maximal dose of2 mg kg−1 and then orally in a dose of 100 mg b.d. or 100 mg t.d.s.) in the conversion to sinus rhythm of 50 patients exhibiting supraventricular arrhythmias (39 ...
DUC, J., FINCI, L., GOY, J.-J, GRBIC, M., HURNI, M., MAENDLY, R., SIGWART, U.   +6 more
core  

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Oral flecainide is effective in management of refractory tachycardia in infants

Indian Heart Journal, 2013
Background: Propranolol and digoxin have been used as first line drugs for treatment of supraventricular tachycardia (SVT) in infants. Flecainide and other drugs have been effective as a second line treatment for controlling refractory SVT.
Vikas Kohli
doaj   +1 more source

Confronto randomizzato tra ablazione circonferenziale delle vene polmonari e terapia antiaritmica in pazienti con fibrillazione atriale parossistica – Studio APAF (Ablation for Paroxysmal Atrial Fibrillation) [PDF]

, 2011
Il presente progetto di ricerca focalizza la sua attenzione su due aree di crescente interesse della cardiologia in generale e dell’aritmologia in particolare: la fibrillazione atriale e l’insufficienza cardiaca.
Petretta, Andrea
core   +1 more source

First‐Line Antiarrhythmic Transplacental Treatment for Fetal Tachyarrhythmia: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThere is no consensus on the most effective and best tolerated first‐line antiarrhythmic treatment for fetal tachyarrhythmia. The purpose of this systematic review and meta‐analysis was to compare the efficacy, safety, and fetal–maternal ...
Tarek Alsaied, Shankar Baskar, Munes Fares, Fares Alahdab, Richard J Czosek, Mohammad Hassan Murad, Larry J Prokop, Allison A Divanovic   +7 more
doaj   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Analysis of the high-frequency content in human qrs complexes by the continuous wavelet transform: An automatized analysis for the prediction of sudden cardiac death [PDF]

, 2018
Background: Fragmentation and delayed potentials in the QRS signal of patients have been postulated as risk markers for Sudden Cardiac Death (SCD). The analysis of the high-frequency spectral content may be useful for quantification.
Calvo Cuervo, David, Cos Juez, Francisco Javier de, García Iglesias, Daniel, Roqueñí Gutiérrez, María Nieves   +3 more
core   +2 more sources

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Flecainide use in arrhythmic patients who have structural heart disease

Therapeutic Advances in Drug Safety
Background: Current guidelines recommend the use of only on a limited basis in patients with normal or minimal structural heart disease. The CAST study, the only randomized controlled trials, showed increased mortality from long-term flecainide use in ...
Naruepat Sangpornsuk, Voravut Rungpradubvong, Tachawut Tiensantisuk, Pattranee Leelapattana, Ronpichai Chokesuwattanakul, Somchai Prechawat   +5 more
doaj   +1 more source

Changes in heart rate and heart rate variability as a function of age in Thoroughbred horses. [PDF]

, 2017
We investigated changes in heart rate (HR) and HR variability as a function of age in newborn foals to old Thoroughbred horses. Experiments were performed on a total of 83 healthy and clinically normal Thoroughbred horses.
Jones, James H, Ohmura, Hajime
core   +1 more source