Results 71 to 80 of about 13,651 (209)

Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients

Stem Cells International, 2018
Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for catecholaminergic polymorphic ventricular tachycardia (CPVT). In this study, we evaluated antiarrhythmic efficacy of carvedilol and flecainide in CPVT patient-specific induced ...
R. P. Pölönen, K. Penttinen, H. Swan, K. Aalto-Setälä   +3 more
doaj   +1 more source

Thrombolysis in a stroke patient on dabigatran anticoagulation: case report and synopsis of published cases [PDF]

, 2013
We present the case of an aphasic 77-year-old stroke patient with left distal M1 occlusion who received rt-PA for thrombolysis while on oral anticoagulant treatment with dabigatran (150 mg b.i.d.).
Abruscato, Mario Giovanni Rosario, Baas, Horst, Hövelmann, Susanne, Pfeilschifter, Waltraud   +3 more
core   +2 more sources

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Flecainide [PDF]

Reactions Weekly, 2020
  +5 more sources

Flecainide associated torsade de pointes: A potential case of reverse use dependence

Journal of Research in Medical Sciences, 2013
Flecainide has been known to cause torsades de pointes (TdP) in patients with structural heart disease and its mechanism has been attributed to use-dependency.
Kevin Hayes, Abhishek Deshmukh, Sadip Pant, Benjamin Culp, James Marsh, Hakan Paydak   +5 more
doaj  

Episodic neurologic disorders: syndromes, genes, and mechanisms. [PDF]

, 2013
Many neurologic diseases cause discrete episodic impairment in contrast with progressive deterioration. The symptoms of these episodic disorders exhibit striking variety.
Fu, Ying-Hui, Ptáček, Louis J, Russell, Jonathan F   +2 more
core   +2 more sources

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Flecainide toxicity—Clinical diagnosis and management of an urgent condition

Clinical Case Reports
Key Clinical Message Clinical suspicion, clinical presentation, and electrocardiogram can help clinicians diagnose flecainide toxicity. Currently, there are no guidelines for the management of patients with flecainide toxicity.
George Bazoukis, Polyxeni Efthymiou, Andronicos Yiannikourides, Elina Khattab, Varnavas Dimitriades, Gary Tse, Marios Pavlou, Panagiota Georgiou, Lorentzos Kapetis, Dimitrios Patestos, Michalis Tsielepis, Kimon Myrianthopoulos, Elias Papasavvas, Theodoros Christophides   +13 more
doaj   +1 more source

Flecainide challenge test: Predictors of unmasking of type 1 Brugada ECG pattern among those with non-type 1 Brugada ECG pattern

Indian Pacing and Electrophysiology Journal, 2016
Background: Many subjects in community have non-type 1 Brugada pattern ECG with atypical symptoms, relevance of which is not clear. Provocative tests to unmask type 1 Brugada pattern in these patients would help in diagnosing Brugada Syndrome.
Srinivasa Prasad, Narayanan Namboodiri, Anees Thajudheen, Gurbhej Singh, Mukund A. Prabhu, S.P. Abhilash, Krishnakumar Mohanan Nair, Aamir Rashid, V.K. Ajit Kumar, Jaganmohan A. Tharakan   +9 more
doaj   +1 more source

Supraventricular tachycardias in the first year of life: what is the best pharmacological treatment? 24 years of experience in a single centre

BMC Cardiovascular Disorders, 2021
Background Supraventricular tachycardias (SVTs) are common in the first year of life and may be life-threatening. Acute cardioversion is usually effective, with both pharmacological and non-pharmacological procedures.
Guglielmo Capponi, Gilda Belli, Mattia Giovannini, Giulia Remaschi, Alice Brambilla, Francesca Vannuccini, Silvia Favilli, Giulio Porcedda, Luciano De Simone   +8 more
doaj   +1 more source