Results 71 to 80 of about 14,613 (227)

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Supraventricular tachycardias in the first year of life: what is the best pharmacological treatment? 24 years of experience in a single centre

BMC Cardiovascular Disorders, 2021
Background Supraventricular tachycardias (SVTs) are common in the first year of life and may be life-threatening. Acute cardioversion is usually effective, with both pharmacological and non-pharmacological procedures.
Guglielmo Capponi, Gilda Belli, Mattia Giovannini, Giulia Remaschi, Alice Brambilla, Francesca Vannuccini, Silvia Favilli, Giulio Porcedda, Luciano De Simone   +8 more
doaj   +1 more source

Efficacy and Safety of Various First-Line Therapeutic Strategies for Fetal Tachycardias: A Network Meta-Analysis and Systematic Review

Frontiers in Pharmacology, 2022
Background: Fetal arrhythmias are common cardiac abnormalities associated with high mortality due to ventricular dysfunction and heart failure, particularly when accompanied by hydrops.
Jiangwei Qin, Zhengrong Deng, Changqing Tang, Yunfan Zhang, Ruolan Hu, Jiawen Li, Yimin Hua, Yifei Li   +7 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Arrhythmogenic effect of flecainide toxicity [PDF]

, 2013
Flecainide is a class 1C antiarrhythmic drug especially used for the management ofsupraventricular arrhythmia. In overdose cases, flecainide can induce life treating ventriculararrhythmias and cardiogenic shock.
Bonnefoy, Eric, Sibellas, Franck, Mullier, Audrey, Kirkorian, G., Sibellas, F., Mullier, A., Kirkorian, Gilbert, Ranc, S., Ranc, Sylvain, Courand, Pierre-Yves, Courand, P. Y., Courand, Pierre-Yves nd   +11 more
core   +1 more source

Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients

Stem Cells International, 2018
Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for catecholaminergic polymorphic ventricular tachycardia (CPVT). In this study, we evaluated antiarrhythmic efficacy of carvedilol and flecainide in CPVT patient-specific induced ...
R. P. Pölönen, K. Penttinen, H. Swan, K. Aalto-Setälä   +3 more
doaj   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Review on Flecainide Poisoning

, 2002
Flecainide acetate is a Vaughn-Williams class IC antiarrhythmic. It is used mainly for treatment of supraventricular arrhythmias due to reentry and is highly effective in suppressing frequent premature ventricular depolarization and nonsustained ...
Cy Man, ITF Cheung
core   +1 more source

Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia

JAMA cardiology, 2017
Importance Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal genetic arrhythmia syndrome characterized by polymorphic ventricular tachycardia with physical or emotional stress, for which current therapy with &bgr ...
P. Kannankeril, J. Moore, M. Cerrone, Silvia G. Priori, Naomi J. Kertesz, Pamela S. Ro, A. Batra, Elizabeth S. Kaufman, David L. Fairbrother, E. Saarel, S. Etheridge, R. Kanter, M. Carboni, Matthew V. Dzurik, D. Fountain, Heidi Chen, E. W. Ely, D. Roden, B. Knollmann   +18 more
semanticscholar   +1 more source