Results 71 to 80 of about 8,945 (197)

Effects of MiRP1 and DPP6 beta-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels

, 2008
Background and purpose: The human cardiac transient outward potassium current (Ito) is believed to be composed of the pore-forming Kv4.3 alpha-subunit, coassembled with modulatory beta-subunits as KChIP2, MiRP1 and DPP6 proteins.
Vaquero González, Luis Miguel, Tamargo Menéndez, Juan, Ravens, Ursula, Delpón Mosquera, María Eva, Wettwer, Eric, Caballero Collado, Ricardo, Gómez García, Ricardo, Núñez Fernández, Lucía, Radicke, Susanne   +8 more
core   +1 more source

Time‐dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses [PDF]

, 2018
Background, Objective: Pharmacological treatment of atrial fibrillation (AF) in horses can be challenging because of low efficacy and adverse effects. Flecainide has been tested with variable efficacy.
Hesselkilde, Eva Z., Pehrson, Steen, Jespersen, Thomas, Tfelt-Hansen, Jacob, Fenner, Merle, Kanters, Jorgen K., Flethøj, Mette, Loft-Andersen, Ameli V., Flethoj, Mette, Carstensen, Helena, Buhl, Rikke, Kanters, Jørgen K., Sattler, Stefan M.   +12 more
core   +1 more source

Left Ventricular Global Longitudinal Strain Is Associated With Appropriate Therapies for Ventricular Arrhythmias Independent of Left Ventricular Ejection Fraction in Patients With Primary Prevention Defibrillators

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Reduced (absolute value) left ventricular global longitudinal strain is independently associated with an increased risk of appropriate therapies from primary prevention implantable cardioverter defibrillators. ABSTRACT Background Left ventricular ejection fraction (LVEF) has not demonstrated reliability in predicting ventricular arrhythmias or ...
Justin Rackley, Muhammad Soofi, Gregory M. Burkman, Carlos Contreras, Habib Yazgi, Mario D. Gonzalez, Gerald V. Naccarelli, Ankit Maheshwari   +7 more
wiley   +1 more source

Flecainide Induced Wide Complex Tachycardia

, 2021
Flecainide can increase QRS duration especially with tachycardia (positive use dependence) and organize atrial fibrillation to atrial ...
Zachariah, Shilla
core  

Zero Fluoroscopy Radiofrequency Slow‐Pathway Modification for AVNRT in Patients ≤ 21 Years: A Single‐Center Cohort and Contextual Review of Literature

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
In 125 consecutive pediatric and young adult patients (age ≤ 21 years), zero‐fluoroscopy radiofrequency slow‐pathway modification for AVNRT—guided entirely by CARTO 3D electroanatomic mapping—achieved 100% acute success, zero recurrences at 36‐month follow‐up, and zero major complications, supporting fluoroless RF ablation as a durable first‐line ...
Shailendra Upadhyay, Whitney Fairchild, Jamie Bopp, Cesar Igor Mesia   +3 more
wiley   +1 more source

Altered flecainide disposition in healthy volunteers taking quinine.

, 1990
The pharmacokinetics of flecainide and its two sequential metabolites, both free and conjugated, its pharmacodynamics, and the influence of simultaneously administered quinine, have been studied in 10 healthy subjects.
Reymond-Michel, G., Biollaz, J., Munafo, A.   +2 more
core   +1 more source

Long‐Term Outcomes of Radiofrequency Atrioventricular Node Ablation in a Real‐World Population

Pacing and Clinical Electrophysiology, Volume 49, Issue 6, Page 698-706, June 2026.
ABSTRACT Background While interventional strategies have expanded the options for long term rhythm restoration, rate control continues to play a pivotal role in the treatment of atrial arrhythmias; however, pharmacologic strategies alone often fail in achieving effective rate control.
Vanessa Sciacca, Nora‐Kristin Brandt, Thomas Fink, Denise Guckel, Maximilian Mörsdorf, Yuri Bocchini, Martin Braun, Moneeb Khalaph, Karen Harutyunyan, Nadica Trajkovska, Philipp Lucas, Thomas Eitz, Maxim Didenko, Philipp Sommer, Christian Sohns   +14 more
wiley   +1 more source

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

Flecainide acetate for the treatment of atrial and ventricular arrhythmias

, 2013
INTRODUCTION: Flecainide is a class Ic antiarrhythmic agent available in Europe since 1982. The clinical development program of flecainide provided good data on its antiarrhythmic effect for the prevention of ventricular and supraventricular arrhythmias.
Kirchhof, Paulus; id_orcid, Fabritz, Larissa; id_orcid, Breithardt, Günter, Apostolakis, Stavros, Tebbe, Ulrich, Oeff, Michael   +5 more
core   +1 more source

Cardiogenic Shock in a Hemodialyzed Patient on Flecainide: Treatment with Intravenous Fat Emulsion, Extracorporeal Cardiac Life Support, and CytoSorb® Hemoadsorption

Case Reports in Cardiology, 2019
A 67-year-old woman with a history of end-stage renal disease on hemodialysis received a therapeutic dose (150 mg daily) of flecainide for three weeks.
Nicolas De Schryver, Philippe Hantson, Vincent Haufroid, Mélanie Dechamps   +3 more
doaj   +1 more source