Results 51 to 60 of about 13,651 (209)

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, EarlyView.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

Frequency Analysis of Atrial Fibrillation From the Surface Electrocardiogram [PDF]

, 2004
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Neither the natural history of AF nor its response to therapy are sufficiently predictable by clinical and echocardiographic parameters.
Bollmann, Andreas, Husser, Daniela, Olsson, Bertil, Sornmo, Leif, Stridh, Martin   +4 more
core  

Effect of sotalol on heart rate, QT interval, and atrial fibrillation cycle length in horses with atrial fibrillation [PDF]

, 2018
Background: Based on its pharmacokinetic profile and electrophysiological effects in healthy horses, sotalol potentially could be used as a long-term PO antiarrhythmic drug in horses.
Anderson, Barrell, Brakel, Broux, Broux, Campbell, Clercq, Clercq, Clercq, Decloedt, Decloedt, Decloedt, Deem, Dufourni, Haugaard, Heliczer, January, Kerin, Lafuente-Lafuente, Loon, Mansour, McGurrin, Meurs, Milan, Pedersen, Rasmussen, Reef, Reef, Verheyen, Wang, Wijffels, Wijffels   +31 more
core   +2 more sources

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Successful treatment of arrhythmia with β‐blocker and flecainide combination in pregnant patients with Andersen–Tawil syndrome: A case report and literature review

Annals of Noninvasive Electrocardiology, 2021
Andersen–Tawil syndrome (ATS) is a rare disorder characterized by a triad of ventricular arrhythmia (VA), dysmorphic features, and periodic paralysis.
Pongprueth Rujirachun, Apichaya Junyavoraluk, Manop Pithukpakorn, Bhoom Suktitipat, Arjbordin Winijkul   +4 more
doaj   +1 more source

Antiarrhythmic Drug Therapy in Arrhythmogenic Right Ventricular Cardiomyopathy

Biomedicines, 2023
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable progressive myocardial disorder that predisposes patients to ventricular arrhythmias and sudden cardiac death.
Sean P. Gaine, Hugh Calkins
doaj   +1 more source

Catheter ablation vs. antiarrhythmic drug therapy in patients with symptomatic atrioventricular nodal re-entrant tachycardia: a randomized, controlled trial. [PDF]

, 2017
Aims: To conduct a randomized trial in order to guide the optimum therapy of symptomatic atrioventricular nodal re-entrant tachycardia (AVNRT).
Camm, AJ, Giazitzoglou, E, Josephson, ME, Katritsis, DG, Katritsis, GD, Paxinos, G, Vachliotis, V, Zografos, T   +7 more
core   +1 more source

Characterization of AV Nodal Left Inferior Extension by Use of High‐Density Mapping and Voltage‐Time Relationship

Journal of Cardiovascular Electrophysiology, EarlyView.
High resolution voltage LA map is shown with Ripple mapping during sinus rhythm prior to atrial fibrillation ablation (panel A‐D, top row Left Anterior Oblique view, bottom row Left Anterior Oblique Caudal view). Chamber activation is visualized by white Ripple bars, proceeding from the septum and septal roof (panel A), spreading clockwise and ...
June K. Pickett, Joshua R. Hirsch, Michael Charles C. Tan, Abdi Rasekh, Joanna E. Molina‐Razavi, Mehdi Razavi, Mihail G. Chelu, Payam Safavi‐Naeini, Mohammad Saeed   +8 more
wiley   +1 more source

Rate-Control or Rhythm-Contol: Where do we stand? [PDF]

, 2005
Atrial fibrillation is the most common sustained rhythm disturbance and its prevalence is increasing worldwide due to the progressive aging of the population.
A, Dello Russo, F, Andreotti, F, Bellocci, G, Pelargonio, G, Trotta, L, Testa, M, Casella   +6 more
core   +1 more source

Left Atrial Posterior Wall Functional Remodeling in Paroxysmal and Persistent Atrial Fibrillation. A Pilot Study

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background The left atrial posterior wall (LAPW) is often targeted in atrial fibrillation (AF) ablation due to its shared properties with pulmonary veins. However, substrate‐guided approaches using structural markers have shown inconsistent results.
Michael M. Malaty, Natasha Trevaskis, Kerissa Govender, Aaron L. Sverdlov, Bradley R. Wilsmore, Malcolm Barlow, Nicholas Jackson, Gwilym M. Morris   +7 more
wiley   +1 more source