Results 51 to 60 of about 14,613 (227)

IS THE DEBATE ON THE FLECAINIDE ACTION ON THE RYR2 IN CPVT CLOSED?

Circulation Research, 2021
The class IC antiarrhythmic agent flecainide, developed in the 70s as a more stable local anesthetic by incorporating of fluorine, is nowadays recommended as one of the first-line rhythm control therapeutic options in patients without significant ...
J. Benitah, A. Gómez
semanticscholar   +1 more source

Flecainide for the Treatment of Andersen-Tawil Syndrome.

JACC Clinical Electrophysiology
BACKGROUND Andersen-Tawil syndrome type 1 (ATS1) is a rare arrhythmogenic disorder resulting from loss-of-function mutations in KCNJ2. Although the use of flecainide has been proposed to treat and prevent life-threatening arrhythmic events in ATS1, it ...
Tomer Mann, Ayhan Yoruk, R. Neves, A. Bergman, M. Bos, C. van der Werf, M. H. Gollob, Jason D. Roberts, H. Khan, S. Sanatani, V. Vedantham, Byron K. Lee, Anastasiea Yesaulov, Andrew D. Krahn, R. Tadros, A. A. Wilde, M. Ackerman, Melvin M. Scheinman   +17 more
semanticscholar   +1 more source

Flecainide overdose-induced Brugada electrocardiogram pattern

, 2017
A 64-year-old female with paroxysmal atrial fibrillation presented to the emergency department with atrial fibrillation and rapid ventricular rate (Figure 1A), which was refractory to her usual combination doses of ‘pill-in-pocket’ metoprolol (25 mg) and
Greaves, K., Nam, MCY, Greaves, Kim, E.-A. Karlsen, Dayananda, N., Stanton, T., Stanton, T, N. Dayananda, Karlsen, EA, Karlsen, E-A, Woo, E., Greaves, K, T. Stanton, K. Greaves, Karlsen, E.-A., E. Woo, Nam, Michael C Y, Dayananda, N, Nam, M. C. Y., M.C.Y. Nam, Woo, E   +20 more
core   +1 more source

Comparison of dronedarone vs. flecainide in the maintenance of sinus rhythm, following electrocardioversion in adults with persistent atrial fibrillation: a systematic review and meta-analysis

, 2021
Aims: To compare flecainide and dronedarone for sinus rhythm (SR) maintenance following electrocardioversion of persistent atrial fibrillation (AF), in patients with minimal or no structural heart disease.
Wilson, Hannah, O'Connor, Tom, Nugent, Linda, Moore, Zena, Patton, Declan   +4 more
core   +1 more source

ECTOPIC trial: The efficacy of flEcainide Compared To metOprolol in reducing Premature ventrIcular contractions. A randomized open label cross-over study in pediatric patients.

Heart Rhythm
BACKGROUND Frequent premature ventricular contractions (PVCs) in children are usually considered benign. Symptoms and/or left ventricular dysfunction are indications for treatment with anti-arrhythmic drugs (AAD).
R. Bertels, J. Kammeraad, N. van Geloven, Luc Filippini, R. V. D. van der Palen, Ramon O. Tak, S. Frerich, Ward Vanagt, Jan J. B. Rehbock, Ingmar Knobbe, I. Kuipers, M. de Riva, Katja Zeppenfeld, Nico A. Blom   +13 more
semanticscholar   +1 more source

Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification

, 2010
Both increase and decrease of cardiac inward rectifier current (I K1 ) are associated with severe cardiac arrhythmias.
Irene Amorós, Duarte, Juan, González de la Fuente, Marta, Eva Delpón, Gómez García, Ricardo, Ricardo Gómez, Amorós García, Irene, Juan Duarte, Juan Tamargo, Tamargo Menéndez, Juan, Osuna, Lourdes, López Izquierdo, Angélica, Ignacio Moraleda, Moraleda, Ignacio, Lourdes Osuna, Caballero Collado, Ricardo, Angelica López–Izquierdo, José Antonio Sánchez–Chapula, Barana Muñoz, Adriana, Delpón Mosquera, María Eva, Gálvez Ruano, Enrique, Adriana Barana, Enrique Gálvez, Ricardo Caballero, Pablo Dolz-Gaitón, Sánchez Chapula, José Antonio, Marta González de la Fuente, Dolz Gaitón, Pablo   +27 more
core   +1 more source

Paranoid Psychosis and Myoclonus: Flecainide Toxicity in Renal Failure

Flecainide is a sodium channel blocker used mainly in the treatment of supraventricular arrhythmias. Central nervous system side effects such as dizziness, visual disturbances, headache and nausea are commonly associated with flecainide, but severe ...
Maclean D, Sheerin NS, Ting SM, Lee D
core   +5 more sources

Orally Inhaled Flecainide for Conversion of Atrial Fibrillation to Sinus Rhythm: INSTANT Phase 2 Trial.

JACC Clinical Electrophysiology
BACKGROUND INSTANT (INhalation of flecainide to convert recent-onset SympTomatic Atrial fibrillatioN to sinus rhyThm) was a multicenter, open-label, single-arm study of flecainide acetate oral inhalation solution (FlecIH) for acute conversion of recent ...
J. N. Ruskin, A. Camm, C. Dufton, A. C. Woite-Silva, Y. Tuininga, Erik Badings, J. D. de Jong, T. Oosterhof, I. Aksoy, A. Kuijper, I. V. van Gelder, V. V. van Dijk, D. Nuyens, D. Schellings, M. Y. Lee, Peter R. Kowey, H. Crijns, J. Maupas, L. Belardinelli   +18 more
semanticscholar   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Flecainide drug binding.

, 2016
In panel (A,) a computed Kd curve is generated from Kd = Kd0*e(-d*V*F/(R*T)) with Kd0 = 11.2 (Kd at 0 mV). Kd-100mV = 175.8 μM. See Table 3. Panel B and C are the results from optimization of neutral rate constants for flecainide using a neutral ...
Jonathan D. Moreno (2273986), Timothy J. Lewis (2560219), Colleen E. Clancy (45544)   +2 more
core   +1 more source