Results 31 to 40 of about 8,945 (197)

Brugada pattern masquerading as ST-segment elevation myocardial infarction in flecainide toxicity

Indian Heart Journal, 2012
Flecainide (a class 1c antiarrhythmic) produces a dose-dependent decrease in intracardiac conduction. Its well known common electrocardiographic effects are prolongation of PR and QT intervals and the QRS complex duration.
Lovely Chhabra, David H. Spodick
doaj   +1 more source

Flecainide Toxicity Leading to Loss of Pacemaker Capture and Cardiac Arrest

JACC: Case Reports, 2021
An 86-year-old man with paroxysmal atrial fibrillation on flecainide, a class IC antiarrhythmic, presented with cardiac arrest. The patient had extremely wide QRS complexes with inconsistent pacemaker capture on electrocardiography.
Harold Rivner, MD, Litsa K. Lambrakos, MD   +1 more
doaj   +1 more source

Comparison of dronedarone vs. flecainide in the maintenance of sinus rhythm, following electrocardioversion in adults with persistent atrial fibrillation: a systematic review and meta-analysis

, 2021
Aims: To compare flecainide and dronedarone for sinus rhythm (SR) maintenance following electrocardioversion of persistent atrial fibrillation (AF), in patients with minimal or no structural heart disease.
Wilson, Hannah, O'Connor, Tom, Nugent, Linda, Moore, Zena, Patton, Declan   +4 more
core   +1 more source

How does flecainide impact RyR2 channel function?

, 2022
Flecainide, a cardiac class 1C blocker of the surface membrane sodium channel (NaV1.5), has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated sarcoplasmic reticulum (SR) Ca2+ release.

core   +1 more source

Flecainide overdose-induced Brugada electrocardiogram pattern

, 2017
A 64-year-old female with paroxysmal atrial fibrillation presented to the emergency department with atrial fibrillation and rapid ventricular rate (Figure 1A), which was refractory to her usual combination doses of ‘pill-in-pocket’ metoprolol (25 mg) and
Greaves, K., Nam, MCY, Greaves, Kim, E.-A. Karlsen, Dayananda, N., Stanton, T., Stanton, T, N. Dayananda, Karlsen, EA, Karlsen, E-A, Woo, E., Greaves, K, T. Stanton, K. Greaves, Karlsen, E.-A., E. Woo, Nam, Michael C Y, Dayananda, N, Nam, M. C. Y., M.C.Y. Nam, Woo, E   +20 more
core   +1 more source

Flecainide and amiodarone interaction

, 1986
Oral amiodarone therapy was given to seven patients already taking oral flecainide regularly. In one additional patient, administration of flecainide was temporarily discontinued when amiodarone therapy was begun, and then resumed.
Kim, Sung Soon, Shea, Patrick, Schechtman, Kenneth, Lal, Roop, Ruffy, Rodolphe   +4 more
core   +1 more source

Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification

, 2010
Both increase and decrease of cardiac inward rectifier current (I K1 ) are associated with severe cardiac arrhythmias.
Irene Amorós, Duarte, Juan, González de la Fuente, Marta, Eva Delpón, Gómez García, Ricardo, Ricardo Gómez, Amorós García, Irene, Juan Duarte, Juan Tamargo, Tamargo Menéndez, Juan, Osuna, Lourdes, López Izquierdo, Angélica, Ignacio Moraleda, Moraleda, Ignacio, Lourdes Osuna, Caballero Collado, Ricardo, Angelica López–Izquierdo, José Antonio Sánchez–Chapula, Barana Muñoz, Adriana, Delpón Mosquera, María Eva, Gálvez Ruano, Enrique, Adriana Barana, Enrique Gálvez, Ricardo Caballero, Pablo Dolz-Gaitón, Sánchez Chapula, José Antonio, Marta González de la Fuente, Dolz Gaitón, Pablo   +27 more
core   +1 more source

Efficacy and Safety of Various First-Line Therapeutic Strategies for Fetal Tachycardias: A Network Meta-Analysis and Systematic Review

Frontiers in Pharmacology, 2022
Background: Fetal arrhythmias are common cardiac abnormalities associated with high mortality due to ventricular dysfunction and heart failure, particularly when accompanied by hydrops.
Jiangwei Qin, Zhengrong Deng, Changqing Tang, Yunfan Zhang, Ruolan Hu, Jiawen Li, Yimin Hua, Yifei Li   +7 more
doaj   +1 more source

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self‐Reported Drug Use

Drug Testing and Analysis, EarlyView.
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
A. Y. Simão, T. Rosado, M. Barroso, M. Andraus, E. Gallardo   +4 more
wiley   +1 more source

Flecainide drug binding.

, 2016
In panel (A,) a computed Kd curve is generated from Kd = Kd0*e(-d*V*F/(R*T)) with Kd0 = 11.2 (Kd at 0 mV). Kd-100mV = 175.8 μM. See Table 3. Panel B and C are the results from optimization of neutral rate constants for flecainide using a neutral ...
Jonathan D. Moreno (2273986), Timothy J. Lewis (2560219), Colleen E. Clancy (45544)   +2 more
core   +1 more source