Results 31 to 40 of about 14,613 (227)

The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats [PDF]

Acute and Critical Care, 2018
Background Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action is contended.
Shi Young Chung, Jinyoung Kim, Hong Bum Bae, Tran Duc Tin, Wan Ju, Sang Hyun Kwak   +5 more
doaj   +1 more source

Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor

, 2022
Flecainide is used to treat catecholaminergic polymorphic ventricular tachycardia (CPVT), an arrhythmia caused by disrupted cellular Ca2+ handling following β‐adrenergic stimulation.
M. Bannister, K. T. Macleod, Christopher H. George   +2 more
semanticscholar   +1 more source

Exercise Testing With Flecainide Demonstrates Provocable Brugada Syndrome

CJC Open, 2021
A young man with baseline early repolarization was initiated on flecainide and diltiazem for symptomatic atrial arrhythmias. A treadmill stress test induced a type 1 Brugada electrocardiogram pattern at higher heart rates.
Sina Safabakhsh, BSc,, Andrew D. Krahn, MD, FHRS,, Zachary Laksman, MD, MSc   +2 more
doaj   +1 more source

A Case Report of Flecainide Toxicity With Review of Literature

Cureus, 2022
Flecainide is an anti-arrhythmic drug with a narrow therapeutic index. Flecainide toxicity is rare, but the mortality is high. This case demonstrates the use of intravenous fat emulsion therapy in conjunction with intravenous sodium bicarbonate treatment
P. Khatiwada, Lindsey D Clark, A. Khunger, Bhimesh B Rijal, Jody Ritter   +4 more
semanticscholar   +1 more source

Flecainide administration in children: dosage, drug levels, and clinical effect [PDF]

, 2023
Therapeutic drug monitoring of flecainide in children using plasma concentration measurements is undertaken by some clinicians. There is very little published evidence surrounding factors which influence plasma flecainide concentration, particularly in ...
Thomas, Shôn A. L., Ferguson, Richard, Wilson, Dirk G., Richard Ferguson, Shôn A. L. Thomas, Dirk G. Wilson   +5 more
core   +1 more source

Safety and efficacy of flecainide associated with beta-blockers in arrhythmogenic right ventricular cardiomyopathy.

Europace, 2021
AIMS Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy associated with a high risk of ventricular arrhythmia (VA). Current guidelines recommend beta-blockers as first-line medical therapy and if ineffective, sotalol or
T. Rolland, N. Badenco, C. Maupain, G. Duthoit, X. Waintraub, M. Laredo, C. Himbert, R. Frank, F. Hidden-Lucet, E. Gandjbakhch   +9 more
semanticscholar   +1 more source

The Unpaceable Heart

JACC: Case Reports, 2020
This is a case of flecainide toxicity in a patient with a permanent pacemaker. This case not only highlights the effects of flecainide toxicity on surface electrocardiography but how toxicity effects pacemaker function and its ability to transvenously ...
James Nadel, MBBS, MMed, Gayathri Kumarasinghe, PhD, Rajesh Subbiah, PhD   +2 more
doaj   +1 more source

Flecainide and amiodarone interaction [PDF]

, 1986
Oral amiodarone therapy was given to seven patients already taking oral flecainide regularly. In one additional patient, administration of flecainide was temporarily discontinued when amiodarone therapy was begun, and then resumed.
Kim, Sung Soon, Shea, Patrick, Schechtman, Kenneth, Lal, Roop, Ruffy, Rodolphe   +4 more
core   +1 more source

Flecainide reduces ventricular arrhythmias via a mechanism that differs from that of β-blockers in catecholaminergic polymorphic ventricular tachycardia

Journal of Arrhythmia, 2013
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by episodic ventricular tachycardia induced by adrenergic stress.
Kenichi Dochi, Hiroshi Watanabe, Mihoko Kawamura, Akashi Miyamoto, Tomoya Ozawa, Yuko Nakazawa, Takashi Ashihara, Seiko Ohno, Hideki Hayashi, Makoto Ito, Hisanori Sakazaki, Hiro Kawata, Hiroya Ushinohama, Richard H. Kaszynski, Tohru Minamino, Naokata Sumitomo, Wataru Shimizu, Minoru Horie   +17 more
doaj   +1 more source

RYR2 Channel Inhibition Is the Principal Mechanism 0f Flecainide Action in CPVT

Circulation Research, 2020
Rationale: The class Ic antiarrhythmic drug flecainide prevents ventricular tachyarrhythmia in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a disease caused by hyperactive cardiac ryanodine receptor (RyR2) calcium (Ca ...
D. Kryshtal, Daniel J. Blackwell, Christian L. Egly, Abigail N. Smith, Suzanne M. Batiste, J. Johnston, D. Laver, B. Knollmann   +7 more
semanticscholar   +1 more source