Results 11 to 20 of about 13,651 (209)

Flecainide‐Induced Interstitial Lung Disease: A Case Report and Review of the Literature

Clinical Case Reports
This case describes a rare adverse effect in which the subject developed interstitial lung disease after initiating a class IC antiarrhythmic, flecainide.
Elizabeth Jenkins, John McGinty, Brian Skinner   +2 more
doaj   +2 more sources

Flecainide for conversion and maintenance of sinus rhythm after mitral valve replacement in rheumatic atrial fibrillationWhat is Already Known?What this Study Adds

Indian Heart Journal, 2023
Background: Despite successful mitral valve replacement (MVR), many patients remain in AF. Flecainide can be useful in these patients but has not been used because of underlying structural heart disease.
Umesh Tripathi, Aditya Kapoor, Surendra Kumar Agarwal, Prabhat Tewari, Shantanu Pande, Bipin Chandra, Ankit Sahu, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari   +10 more
doaj   +1 more source

The cardiac work-loop technique:An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles [PDF]

, 2020
The cardiac work-loop technique closely mimics the intrinsic in vivo movement and characteristics of cardiac muscle function. In this study, six known inotropes were profiled using the work-loop technique to evaluate the potential of this method to ...
AJ Taberner, AM Aylin, AW Tank, CW Scott, D Burkhoff, D Mehra, DA Eisner, DM Bers, DR Varma, E Takimoto, FG Spinale, H Lüllman, J Layland, J Layland, J Layland, J Layland, J Layland, J Tallis, JI Schwartz, JJ Lynch, JL Holtzman, JR Blinks, JS Landzberg, K Noguchi, K Sagawa, KC Vinnakota, L Batista, L Brown, L Butler, L Guo, LJ Mellors, M Eichelbaum, M Gharanei, MA Rosic, ME Conolly, MF Peters, MS Parmacek, P Bergson, R Beigel, R Josephson, R Lewis, R Seifert, R Zhang, RA Nishimura, RC Heel, RD Olson, RK Josephson, RM Bell, RS James, T Akera, T Bombardini, T Delhaas, VJ Caiozzo, W Kerns, W Semafuko, WA Catterall, Y Kihara   +56 more
core   +1 more source

The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats [PDF]

Acute and Critical Care, 2018
Background Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action is contended.
Shi Young Chung, Jinyoung Kim, Hong Bum Bae, Tran Duc Tin, Wan Ju, Sang Hyun Kwak   +5 more
doaj   +1 more source

Flecainide intoxication in pediatric patients with supraventricular tachycardia

Annals of Pediatric Cardiology, 2020
Flecainide is a class IC antiarrhythmic indicated for ventricular and supraventricular arrhythmias in pediatric patients without structural heart disease.
Guiem Vaquer, Laura Marfil, Josep Ortega, Anna Sabate-Rotes, Ferran Gran-Ipina, Ferran Roses-Noguer   +5 more
doaj   +1 more source

Exercise Testing With Flecainide Demonstrates Provocable Brugada Syndrome

CJC Open, 2021
A young man with baseline early repolarization was initiated on flecainide and diltiazem for symptomatic atrial arrhythmias. A treadmill stress test induced a type 1 Brugada electrocardiogram pattern at higher heart rates.
Sina Safabakhsh, BSc,, Andrew D. Krahn, MD, FHRS,, Zachary Laksman, MD, MSc   +2 more
doaj   +1 more source

The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia

Frontiers in Physiology, 2022
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe yet rare inherited arrhythmia disorder. The cornerstone of CPVT medical therapy is the use of β-blockers; 30% of patients with CPVT do not respond well to optimal β-blocker ...
Yukun Li, Yukun Li, Xiaodong Peng, Xiaodong Peng, Rong Lin, Xuesi Wang, Xuesi Wang, Xinmeng Liu, Xinmeng Liu, Rong Bai, Changsheng Ma, Changsheng Ma, Ribo Tang, Ribo Tang, Yanfei Ruan, Yanfei Ruan, Nian Liu, Nian Liu   +17 more
doaj   +1 more source

SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients [PDF]

, 2013
Objective: An increased slowing of cardiac conduction induced by sodium channel blockers is remarkably observed in carriers of an Asian-specific promoter haplotype [haplotype B (HapB)] of the cardiac sodium channel gene (SCN5A).
Aonuma Kazutaka, Doki Kosuke, Homma Masato, Kohda Yukinao, Kuga Keisuke, 久賀 圭祐, 土岐 浩介, 本間 真人, 青沼 和隆   +8 more
core   +1 more source

Flecainide reduces ventricular arrhythmias via a mechanism that differs from that of β-blockers in catecholaminergic polymorphic ventricular tachycardia

Journal of Arrhythmia, 2013
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by episodic ventricular tachycardia induced by adrenergic stress.
Kenichi Dochi, Hiroshi Watanabe, Mihoko Kawamura, Akashi Miyamoto, Tomoya Ozawa, Yuko Nakazawa, Takashi Ashihara, Seiko Ohno, Hideki Hayashi, Makoto Ito, Hisanori Sakazaki, Hiro Kawata, Hiroya Ushinohama, Richard H. Kaszynski, Tohru Minamino, Naokata Sumitomo, Wataru Shimizu, Minoru Horie   +17 more
doaj   +1 more source

The Unpaceable Heart

JACC: Case Reports, 2020
This is a case of flecainide toxicity in a patient with a permanent pacemaker. This case not only highlights the effects of flecainide toxicity on surface electrocardiography but how toxicity effects pacemaker function and its ability to transvenously ...
James Nadel, MBBS, MMed, Gayathri Kumarasinghe, PhD, Rajesh Subbiah, PhD   +2 more
doaj   +1 more source