Results 11 to 20 of about 8,945 (197)

Flecainide in clinical practice

Cardiology Journal, 2023
Flecainide, similar to encainide and propafenone, is IC class antiarrhythmic, inhibiting Nav1.5 sodium channels in heart muscle cells and modulates cardiac conduction. Despite its over 40-year presence in clinical practice, strong evidence and well-known
Mikołaj Basza, Cezary Maciejewski, Wojciech Bojanowicz, Paweł Balsam, Marcin Grabowski, Przemysław Mitkowski, Maciej Kempa, Oskar Kowalski, Zbigniew Kalarus, Miłosz Jaguszewski, Andrzej Lubiński, Ludmiła Daniłowicz-Szymanowicz, Łukasz Szumowski, Maciej Sterliński, Łukasz Kołtowski   +14 more
doaj   +4 more sources

Maternal, fetal, neonatal and breastmilk flecainide concentration during maternal therapy and lactation: a case report [PDF]

International Breastfeeding Journal, 2023
Background Mothers requiring the antiarrhythmic agent flecainide are often advised not to breastfeed, because of the lack of data concercing neonatal effects and flecainide plasma concentrations following maternal exposure as well as via lactation.
Johanna A. van der Zande, Jérôme M.J. Cornette, Jolien W. Roos-Hesselink, Robert B. Flint   +3 more
doaj   +2 more sources

Flecainide-Associated Cardiogenic Shock in a Patient with Atrial Fibrillation

Case Reports in Cardiology, 2019
Flecainide is a frequently used antiarrhythmic drug, recommended by current guidelines as a first-line treatment option for restoring and maintaining sinus rhythm in patients with atrial fibrillation and no significant structural heart disease.
Erind Gjermeni, Andreas Bollmann, Gerhard Hindricks, Andreas Müssigbrodt   +3 more
doaj   +2 more sources

Neonatal Near Fatal Flecainide Toxicity

Saudi Journal of Emergency Medicine
Background: Flecainide is an anti-arrhythmic medication with a narrow therapeutic index and a high mortality rate, when overdosed. Few cases of flecainide toxicity in neonates and children due to medication error have been reported in the literature.
Fatma Mohammed Abdullah Al Balushi, Said Al-Hinshi, Anita Tandon, Ziad Kazzi, Badria Alhatali, Fatma Mohammed AL Balushi   +5 more
doaj   +2 more sources

Flecainide toxicity—Clinical diagnosis and management of an urgent condition

Clinical Case Reports
Key Clinical Message Clinical suspicion, clinical presentation, and electrocardiogram can help clinicians diagnose flecainide toxicity. Currently, there are no guidelines for the management of patients with flecainide toxicity.
George Bazoukis, Polyxeni Efthymiou, Andronicos Yiannikourides, Elina Khattab, Varnavas Dimitriades, Gary Tse, Marios Pavlou, Panagiota Georgiou, Lorentzos Kapetis, Dimitrios Patestos, Michalis Tsielepis, Kimon Myrianthopoulos, Elias Papasavvas, Theodoros Christophides   +13 more
doaj   +2 more sources

Flecainide use in arrhythmic patients who have structural heart disease

Therapeutic Advances in Drug Safety
Background: Current guidelines recommend the use of only on a limited basis in patients with normal or minimal structural heart disease. The CAST study, the only randomized controlled trials, showed increased mortality from long-term flecainide use in ...
Naruepat Sangpornsuk, Voravut Rungpradubvong, Tachawut Tiensantisuk, Pattranee Leelapattana, Ronpichai Chokesuwattanakul, Somchai Prechawat   +5 more
doaj   +2 more sources

Flecainide for conversion and maintenance of sinus rhythm after mitral valve replacement in rheumatic atrial fibrillationWhat is Already Known?What this Study Adds

Indian Heart Journal, 2023
Background: Despite successful mitral valve replacement (MVR), many patients remain in AF. Flecainide can be useful in these patients but has not been used because of underlying structural heart disease.
Umesh Tripathi, Aditya Kapoor, Surendra Kumar Agarwal, Prabhat Tewari, Shantanu Pande, Bipin Chandra, Ankit Sahu, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari   +10 more
doaj   +1 more source

The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats [PDF]

Acute and Critical Care, 2018
Background Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action is contended.
Shi Young Chung, Jinyoung Kim, Hong Bum Bae, Tran Duc Tin, Wan Ju, Sang Hyun Kwak   +5 more
doaj   +1 more source

Flecainide intoxication in pediatric patients with supraventricular tachycardia

Annals of Pediatric Cardiology, 2020
Flecainide is a class IC antiarrhythmic indicated for ventricular and supraventricular arrhythmias in pediatric patients without structural heart disease.
Guiem Vaquer, Laura Marfil, Josep Ortega, Anna Sabate-Rotes, Ferran Gran-Ipina, Ferran Roses-Noguer   +5 more
doaj   +1 more source

Flecainide administration in children: dosage, drug levels, and clinical effect [PDF]

, 2023
Therapeutic drug monitoring of flecainide in children using plasma concentration measurements is undertaken by some clinicians. There is very little published evidence surrounding factors which influence plasma flecainide concentration, particularly in ...
Thomas, Shôn A. L., Ferguson, Richard, Wilson, Dirk G., Richard Ferguson, Shôn A. L. Thomas, Dirk G. Wilson   +5 more
core   +1 more source