Results 41 to 50 of about 14,613 (227)

Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone

Heart Rhythm, 2021
Background Although atrial fibrillation ablation is increasingly used for rhythm control therapy, antiarrhythmic drugs (AADs) are commonly used, either alone or in combination with ablation. The effectiveness of AADs is highly variable.
Andrew P. Holmes, P. Saxena, S. Kabir, C. O’Shea, S. M. Kuhlmann, Suranjana Gupta, D. Fobian, Clara Apicella, M. O'Reilly, F. Syeda, J. Reyat, Godfrey L. Smith, A. Workman, D. Pavlovic, L. Fabritz, P. Kirchhof   +15 more
semanticscholar   +1 more source

Use of Flecainide for the Treatment of Atrial Fibrillation.

American Journal of Cardiology, 2020
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with substantial morbidity and impairment of quality of life. Restoration and maintenance of normal sinus rhythm is a desirable goal for many patients with AF; however ...
D. Echt, J. Ruskin
semanticscholar   +1 more source

Common Structural Pattern for Flecainide Binding in Atrial-Selective K_v1.5 and Na_v1.5 Channels: A Computational Approach

Pharmaceutics, 2022
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Its treatment includes antiarrhythmic drugs (AADs) to modulate the function of cardiac ion channels.
Yuliet Mazola, José C. E. Márquez Montesinos, David Ramírez, Leandro Zúñiga, Niels Decher, Ursula Ravens, Vladimir Yarov-Yarovoy, Wendy González   +7 more
doaj   +1 more source

Flecainide-Induced QRS Complex Widening Correlates with Negative Inotropy.

Heart Rhythm, 2021
BACKGROUND The negative inotropic effect of Class IC antiarrhythmic drugs limits their use for acute cardioversion of atrial fibrillation (AF). OBJECTIVE In an intact porcine model, we examined effects of pulmonary and intravenous (IV) administration ...
Ana B. Rabelo Evangelista, Felipe R Monteiro, B. Nearing, L. Belardinelli, R. Verrier   +4 more
semanticscholar   +1 more source

Brugada pattern masquerading as ST-segment elevation myocardial infarction in flecainide toxicity

Indian Heart Journal, 2012
Flecainide (a class 1c antiarrhythmic) produces a dose-dependent decrease in intracardiac conduction. Its well known common electrocardiographic effects are prolongation of PR and QT intervals and the QRS complex duration.
Lovely Chhabra, David H. Spodick
doaj   +1 more source

Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review

Pediatric Reports, 2021
Congenital junctional ectopic tachycardia (CJET) is a rare tachyarrhythmia that remains difficult to manage, with suboptimal control in most cases. Here, we report literature research on the use of ivabradine in the treatment of pediatric junctional ...
G. D. di Marco, Angelica De Nigris, A. Pepe, A. Pagano, Giangiacomo Di Nardo, Vincenzo Tipo   +5 more
semanticscholar   +1 more source

Therapeutic difficulties in a patient with Ehlers-Danlos syndrome and numerous symptomatic premature ventricular contractions—case report and literature review

Frontiers in Cardiovascular Medicine, 2023
A 28-year-old female patient diagnosed with Ehlers-Danlos syndrome type III (hypermobile EDS, hEDS) was admitted to the cardiology clinic due to a 3-year history of symptomatic ventricular arrhythmia in the form of multiple premature ventricular ...
Grzegorz Sławiński, Grzegorz Sławiński, Elżbieta Wabich, Maja Hawryszko, Ludmiła Daniłowicz-Szymanowicz, Philippe Chevalier   +5 more
doaj   +1 more source

Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response [PDF]

Korean Journal of Critical Care Medicine, 2016
Background: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses.
Jia Song, Young joong Suh, Hyun jung Lee, Eun a Jang, Hong-beom Bae, Sang-Hyun Kwak   +5 more
doaj   +1 more source

Long-Term Follow-Up Data on Flecainide Use as an Antiarrhythmic in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multicenter Study.

JACC Clinical Electrophysiology
BACKGROUND Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy associated with a high risk of ventricular arrhythmia (VA).
Sean Gaine, Thomas Rolland, B. Asatryan, M. Laredo, James R. Sampognaro, Richard T. Carrick, G. Peretto, Steven A. Muller, A. Villatore, B. Murray, C. Tichnell, A. T. Te Riele, P. Loh, P. Compagnucci, Michela Casella, M. Martini, M. Schiavone, C. Tondo, Chiara Cappelletto, G. Sinagra, M. Merlo, L. Jankelson, M. Delmar, M. Targetti, M. Pieroni, I. Olivotto, Leonardo Calò, M. Graziosi, E. Biagini, H. Tandri, B. Bauce, C. James, Marina Cerrone, Hugh Calkins, E. Gandjbakhch, A. Gasperetti   +35 more
semanticscholar   +1 more source

You cannot ablate the Lernaean Hydra: SCN5A mutation in a patient with multifocal ectopic Purkinje-related premature contractions syndrome treated with Flecainide and an implant of a subcutaneous defibrillator—a case report

European Heart Journal: Case Reports, 2021
Background SCN5A mutations may present with different clinical phenotypes such as Brugada syndrome, long QT3 syndrome, sick sinus syndrome, atrial fibrillation, dilated cardiomyopathy, and the least known multifocal ectopic Purkinje-related premature ...
G. Leventopoulos, A. Perperis, Dimitrios Karelas, G. Almpanis   +3 more
semanticscholar   +1 more source