Results 21 to 30 of about 8,945 (197)

Exercise Testing With Flecainide Demonstrates Provocable Brugada Syndrome

CJC Open, 2021
A young man with baseline early repolarization was initiated on flecainide and diltiazem for symptomatic atrial arrhythmias. A treadmill stress test induced a type 1 Brugada electrocardiogram pattern at higher heart rates.
Sina Safabakhsh, BSc,, Andrew D. Krahn, MD, FHRS,, Zachary Laksman, MD, MSc   +2 more
doaj   +1 more source

The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia

Frontiers in Physiology, 2022
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe yet rare inherited arrhythmia disorder. The cornerstone of CPVT medical therapy is the use of β-blockers; 30% of patients with CPVT do not respond well to optimal β-blocker ...
Yukun Li, Yukun Li, Xiaodong Peng, Xiaodong Peng, Rong Lin, Xuesi Wang, Xuesi Wang, Xinmeng Liu, Xinmeng Liu, Rong Bai, Changsheng Ma, Changsheng Ma, Ribo Tang, Ribo Tang, Yanfei Ruan, Yanfei Ruan, Nian Liu, Nian Liu   +17 more
doaj   +1 more source

Flecainide reduces ventricular arrhythmias via a mechanism that differs from that of β-blockers in catecholaminergic polymorphic ventricular tachycardia

Journal of Arrhythmia, 2013
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by episodic ventricular tachycardia induced by adrenergic stress.
Kenichi Dochi, Hiroshi Watanabe, Mihoko Kawamura, Akashi Miyamoto, Tomoya Ozawa, Yuko Nakazawa, Takashi Ashihara, Seiko Ohno, Hideki Hayashi, Makoto Ito, Hisanori Sakazaki, Hiro Kawata, Hiroya Ushinohama, Richard H. Kaszynski, Tohru Minamino, Naokata Sumitomo, Wataru Shimizu, Minoru Horie   +17 more
doaj   +1 more source

The Unpaceable Heart

JACC: Case Reports, 2020
This is a case of flecainide toxicity in a patient with a permanent pacemaker. This case not only highlights the effects of flecainide toxicity on surface electrocardiography but how toxicity effects pacemaker function and its ability to transvenously ...
James Nadel, MBBS, MMed, Gayathri Kumarasinghe, PhD, Rajesh Subbiah, PhD   +2 more
doaj   +1 more source

Flecainide Toxicity Secondary to Accidental Overdose: A Pediatric Case Report of Two Brothers

Case Reports in Critical Care, 2021
Flecainide is a class 1C antiarrhythmic with a narrow therapeutic window and thereby a high-risk medication for causing acute toxicity. Dysrhythmias secondary to flecainide ingestion are often refractory to antiarrhythmics and cardioversion, and patients
Sarah E. Gardner Yelton, James B. Leonard, Caridad M. de la Uz, Rajeev S. Wadia, Sean S. Barnes   +4 more
doaj   +1 more source

Flecainide is well-tolerated and effective in patient with atrial fibrillation at 12 months: a retrospective study

Therapeutic Advances in Cardiovascular Disease, 2020
Introduction: Current atrial fibrillation (AF) guidelines recommend flecainide as a first-line rhythm control option in patients without structural heart disease. While there is proven efficacy in clinical trials and guideline support, it is hypothesized
Mikayla Muzzey, Katie B. Tellor, Karthik Ramaswamy, Martin Schwarze, Anastasia L. Armbruster   +4 more
doaj   +1 more source

Ranolazine as an Alternative Therapy to Flecainide for SCN5A V411M Long QT Syndrome Type 3 Patients

Frontiers in Pharmacology, 2020
The prolongation of the QT interval represents the main feature of the long QT syndrome (LQTS), a life-threatening genetic disease. The heterozygous SCN5A V411M mutation of the human sodium channel leads to a LQTS type 3 with severe proarrhythmic effects
Jordi Cano, Esther Zorio, Esther Zorio, Andrea Mazzanti, Andrea Mazzanti, Miguel Ángel Arnau, Beatriz Trenor, Silvia G. Priori, Silvia G. Priori, Javier Saiz, Lucia Romero   +10 more
doaj   +1 more source

Common Structural Pattern for Flecainide Binding in Atrial-Selective K_v1.5 and Na_v1.5 Channels: A Computational Approach

Pharmaceutics, 2022
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Its treatment includes antiarrhythmic drugs (AADs) to modulate the function of cardiac ion channels.
Yuliet Mazola, José C. E. Márquez Montesinos, David Ramírez, Leandro Zúñiga, Niels Decher, Ursula Ravens, Vladimir Yarov-Yarovoy, Wendy González   +7 more
doaj   +1 more source

Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response [PDF]

Korean Journal of Critical Care Medicine, 2016
Background: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses.
Jia Song, Young joong Suh, Hyun jung Lee, Eun a Jang, Hong-beom Bae, Sang-Hyun Kwak   +5 more
doaj   +1 more source

Therapeutic difficulties in a patient with Ehlers-Danlos syndrome and numerous symptomatic premature ventricular contractions—case report and literature review

Frontiers in Cardiovascular Medicine, 2023
A 28-year-old female patient diagnosed with Ehlers-Danlos syndrome type III (hypermobile EDS, hEDS) was admitted to the cardiology clinic due to a 3-year history of symptomatic ventricular arrhythmia in the form of multiple premature ventricular ...
Grzegorz Sławiński, Grzegorz Sławiński, Elżbieta Wabich, Maja Hawryszko, Ludmiła Daniłowicz-Szymanowicz, Philippe Chevalier   +5 more
doaj   +1 more source