Results 11 to 20 of about 9,572 (201)

Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action

Cells, 2021
Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation.
Samantha C. Salvage, Esther M. Gallant, James A. Fraser, Christopher L.-H. Huang, Angela F. Dulhunty   +4 more
doaj   +1 more source

Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells

Frontiers in Pharmacology, 2023
Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial.
Emma J. Steer, Zhaokang Yang, Moza M. Al-Owais, Hannah M. Kirton, Edward White, Derek S. Steele   +5 more
doaj   +1 more source

Case report: Use of therapeutic drug monitoring and pharmacogenetic testing as opportunities to individualize care in a case of flecainide toxicity after fetal supraventricular tachycardia

Frontiers in Pediatrics, 2023
Flecainide is a class IC antiarrhythmic utilized in prophylaxis of refractory paroxysmal supraventricular tachycardias in pediatric populations. Despite being a highly effective agent, its narrow therapeutic index increases the risk of toxicity and ...
Ronald Palmen, Ronald Palmen, Ronald Palmen, Tracy Sandritter, Tracy Sandritter, Lindsey Malloy-Walton, Lindsey Malloy-Walton, Lindsey Malloy-Walton, Christopher Follansbee, Christopher Follansbee, Christopher Follansbee, Jonathan B. Wagner, Jonathan B. Wagner, Jonathan B. Wagner, Jonathan B. Wagner, Jonathan B. Wagner   +15 more
doaj   +1 more source

Maternal, fetal, neonatal and breastmilk flecainide concentration during maternal therapy and lactation: a case report

International Breastfeeding Journal, 2023
Background Mothers requiring the antiarrhythmic agent flecainide are often advised not to breastfeed, because of the lack of data concercing neonatal effects and flecainide plasma concentrations following maternal exposure as well as via lactation.
Johanna A. van der Zande, Jérôme M.J. Cornette, Jolien W. Roos-Hesselink, Robert B. Flint   +3 more
doaj   +1 more source

Flecainide for conversion and maintenance of sinus rhythm after mitral valve replacement in rheumatic atrial fibrillationWhat is Already Known?What this Study Adds

Indian Heart Journal, 2023
Background: Despite successful mitral valve replacement (MVR), many patients remain in AF. Flecainide can be useful in these patients but has not been used because of underlying structural heart disease.
Umesh Tripathi, Aditya Kapoor, Surendra Kumar Agarwal, Prabhat Tewari, Shantanu Pande, Bipin Chandra, Ankit Sahu, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari   +10 more
doaj   +1 more source

The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats [PDF]

Acute and Critical Care, 2018
Background Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action is contended.
Shi Young Chung, Jinyoung Kim, Hong Bum Bae, Tran Duc Tin, Wan Ju, Sang Hyun Kwak   +5 more
doaj   +1 more source

Flecainide intoxication in pediatric patients with supraventricular tachycardia

Annals of Pediatric Cardiology, 2020
Flecainide is a class IC antiarrhythmic indicated for ventricular and supraventricular arrhythmias in pediatric patients without structural heart disease.
Guiem Vaquer, Laura Marfil, Josep Ortega, Anna Sabate-Rotes, Ferran Gran-Ipina, Ferran Roses-Noguer   +5 more
doaj   +1 more source

Exercise Testing With Flecainide Demonstrates Provocable Brugada Syndrome

CJC Open, 2021
A young man with baseline early repolarization was initiated on flecainide and diltiazem for symptomatic atrial arrhythmias. A treadmill stress test induced a type 1 Brugada electrocardiogram pattern at higher heart rates.
Sina Safabakhsh, BSc,, Andrew D. Krahn, MD, FHRS,, Zachary Laksman, MD, MSc   +2 more
doaj   +1 more source

The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia

Frontiers in Physiology, 2022
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe yet rare inherited arrhythmia disorder. The cornerstone of CPVT medical therapy is the use of β-blockers; 30% of patients with CPVT do not respond well to optimal β-blocker ...
Yukun Li, Yukun Li, Xiaodong Peng, Xiaodong Peng, Rong Lin, Xuesi Wang, Xuesi Wang, Xinmeng Liu, Xinmeng Liu, Rong Bai, Changsheng Ma, Changsheng Ma, Ribo Tang, Ribo Tang, Yanfei Ruan, Yanfei Ruan, Nian Liu, Nian Liu   +17 more
doaj   +1 more source

Flecainide Toxicity Secondary to Accidental Overdose: A Pediatric Case Report of Two Brothers

Case Reports in Critical Care, 2021
Flecainide is a class 1C antiarrhythmic with a narrow therapeutic window and thereby a high-risk medication for causing acute toxicity. Dysrhythmias secondary to flecainide ingestion are often refractory to antiarrhythmics and cardioversion, and patients
Sarah E. Gardner Yelton, James B. Leonard, Caridad M. de la Uz, Rajeev S. Wadia, Sean S. Barnes   +4 more
doaj   +1 more source