Results 31 to 40 of about 70,005 (261)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Theoretical and Experimental Study of Flexible Structure Tilting Pad Bearings Considering Deformation

Lubricants
In high-speed and heavy-load conditions, ordinary rigid tilting pad journal bearings experience significant contact stress at the pad pivot points, leading to severe pad deformation and increased wear.
Yunyu Wu, Weiwei Zhang, Shuxiang Yi, Xiaojing Wang, Yanyan Qin, Shuxia Peng   +5 more
doaj   +1 more source

Research on static and dynamics mechanical characteristics of flexible bearing in harmonic reducer

International Journal of Advanced Robotic Systems, 2020
Flexible bearing is an important component of harmonic reducer which is widely used in automation equipment, especially in industrial robots. Studying its mechanical characteristics has great significance.
Zhu Caizhi, Wang Xiaojing, Li Zhaolun, Liu Jun, Zheng Jiaqi   +4 more
doaj   +1 more source

Acoustic Journal Bearing With Changeable Geometry and Built-in Flexibility [PDF]

Journal of Tribology, 2018
The influence of embodiment flexibility on the performance of an acoustic journal bearing is presented. Two completely different embodiments of the bearing were investigated using three criteria of performance assessment that is torque at the start-up, amount of separation due to squeeze film pressure, and motion stability of the shaft running at speed.
Stolarski, TA, Miyatake, M
openaire   +3 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

An Improved Analytical Model of a Flexible–Rigid Combined Rolling Bearing with Elastohydrodynamic Lubrication

Machines
In industrial applications, the operating state of bearings can directly affect the performance of mechanical equipment. Local defects, flexible raceways and lubrication have a great impact on the vibration characteristics of rolling bearings.
Qinchao Wang, Zhilong Liu, Xinguang Ma, Zhengquan Wang, Junqin Yu   +4 more
doaj   +1 more source

Bearing capacity of skirted footing subjected to inclined loading

Magazine of Civil Engineering, 2022
Skirted foundations are popular nowadays due to relatively higher bearing capacity and greater stability than strip footing. Foundations are generally subjected to inclined loading in the field.
SHUKLA RAJESH PRASAD
doaj   +1 more source

Including the Effects of Flexible Bearing Supportsin Rotating Machinery [PDF]

International Journal of Rotating Machinery, 2000
Unbalance response and stability analyses of a flexible rotor on three lobe journal bearings on flexible supports are presented. The influence of the support structure was included in the analyses using polynomial transfer functions. These transfer functions were extracted from measured dynamic compliance data of the support structure, measured at the ...
José A. Vázquez, Lloyd E. Barrett, Ronald D. Flack   +2 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Influence of the aircraft bearing surface flexibility on its bearing properties

Information systems, mechanics and control, 2019
The research is devoted to determining the influence of flexural strain on its basic aerodynamic characteristics: the maximum value of aerodynamic perfection, characteristics of longitudinal stability and bearing properties depended on the angle of the wing, the applied profiles type, the deviation of the wing rear edge.The peculiarities of the aerial ...
openaire   +4 more sources