Results 31 to 40 of about 72,796 (265)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Coupled Hydrodynamic–Structural Model for Flexible Interconnected Multiple Floating Bodies

Journal of Marine Science and Engineering, 2023
Evaluating the structural safety and seakeeping performance of very large floating structures (VLFS) using the rigid module flexible connector (RMFC) method remains challenging due to the complexity of the coupled hydrodynamic–structural responses in ...
Mingsheng Chen, Mingjun Ouyang, Hongrui Guo, Meiyan Zou, Chi Zhang   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Derivation of Equations for Flexible Multibody Systems in Terms of Quasi-Coordinates from the Extended Hamilton’s Principle

Shock and Vibration, 1993
Early derivations of the equations of motion for single rigid bodies, single flexible bodies, and flexible multibody systems in terms of quasi-coordinates have been carried out in two stages.
L. Meirovitch
doaj   +1 more source

Improved Vibration Suppression Strategy of Fuzzy PI Servo Control for Dual Flexible System with Flexible Joints

Mathematics, 2023
A high performance manipulator servo drive system is a double flexible system with flexible joints and flexible loads. Flexible joints are composed of elastic connecting elements, and flexible loads are flexible Euler beams with elastic deformation.
Xiangchen Liu, Minghai Wang, Yihan Wang
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Impulse Moments Influence on Single-Frequency Torsional Oscillations of Nonlinear Flexible Bodies

IEEE Access, 2022
The method of analytical study of the influence of impulse moments on nonlinear torsional oscillations of a homogeneous constant cross-section of a body under classical boundary conditions of the first, second, and third types have been developed.
Mariia Sokil, Andriy Andrukhiv, Solomiia Fedushko, Yuriy Syerov, Gregus Michal Ml   +4 more
doaj   +1 more source

Fluttering of Flexible Bodies

Sen'i Kikai Gakkaishi (Journal of the Textile Machinery Society of Japan), 1973
In order to clarify the fluttering bahavior of flexible bodies in air streams, the wave form was assumed as y=ax sin (pt+qx), and from the principle of the energy conservation, p and q were determined asp=-0.415V√ (ρ/ρs) (b/l) (Cx+2k0)q=1.6911/lOn the other hand, fabric or film strips were observed in a vertical wind tunnel, and it was shown that the ...
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source