Results 71 to 80 of about 681,599 (308)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The interaction of multiple bodies and water waves : with the application to the motion of ice floes : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Mathematics at Massey University, Albany, New Zealand [PDF]

, 2002
To understand the propagation of water waves through arrays of floating or (fully or partially) submerged bodies it is necessary to know how these bodies interact with each other under the influence of ambient waves.
Peter, Malte Andreas
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Removal of a Large Stone in the Upper Thoracic Esophagus

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2020
Ingestion of a foreign body is a common occurrence. Flexible endoscopy is most commonly used for treatment, but certain large foreign bodies are more easily retrieved with rigid endoscopy.
Patricia V. Hernandez, MD, Diana L. Snyder, MD, Saba Ghorab, MD, Neej J. Patel, MBBS, Michael L. Hinni, MD, Jennifer L. Horsley-Silva, MD   +5 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

A digital computer program for the dynamic interaction simulation of controls and structure (DISCOS), volume 1 [PDF]

A theoretical development and associated digital computer program system for the dynamic simulation and stability analysis of passive and actively controlled spacecraft are presented. The dynamic system (spacecraft) is modeled as an assembly of rigid and/
Bodley, C. S., Devers, A. D., Frisch, H. P., Park, A. C.   +3 more
core   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Missed distal tracheal foreign body in consecutive bronchoscopies in a 6-year-old boy

Nigerian Journal of Surgery, 2017
It is unusual but not uncommon for foreign bodies to be missed at bronchoscopy. This case report highlights the importance of the clinical history in the diagnosis of aspirated foreign bodies and the usefulness of chest imaging modalities.
Oghenevware Joel Eyekpegha, Uvie U Onakpoya, Perpetua O Obiajunwa, Olusola C Famurewa, Akinwumi B Ogunrombi   +4 more
doaj   +1 more source

Simulation of spacecraft attitude dynamics using TREETOPS and model-specific computer Codes [PDF]

The simulation of spacecraft attitude dynamics and control using the generic, multi-body code called TREETOPS and other codes written especially to simulate particular systems is discussed.
Cochran, John E., Fitz-Coy, Norman G., No, T. S.   +2 more
core   +1 more source

Can Body Flexibility Predict Arterial Stiffening?

Journal of Osteoporosis and Physical Activity, 2018
Arterial stiffness is a risk factor for cardiovascular disorders and mortality. Arterial stiffness increases progressively with aging. Although nobody can escape from age-related arterial stiffening, having a high-level of cardiorespiratory fitness delays age-related arterial stiffening. The primary components of physical fitness are muscular strength,
Kenta Yamamoto, Yuko Gando
openaire   +1 more source