Results 111 to 120 of about 194,546 (266)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Performance of FORTRAN floating-point operations on the Flex/32 multicomputer [PDF]
A series of experiments has been run to examine the floating-point performance of FORTRAN programs on the Flex/32 (Trademark) computer. The experiments are described, and the timing results are presented.
Crockett, Thomas W.
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Overflow-Detectable Floating-Point Fully Homomorphic Encryption
IEEE AccessA floating-point fully homomorphic encryption (FPFHE) is proposed, which is based on torus fully homomorphic encryption equipped with programmable bootstrapping.
Seunghwan Lee, Dong-Joon Shin
doaj +1 more source
A Model-Based Design Floating-Point Accumulator. Case of Study: FPGA Implementation of a Support Vector Machine Kernel Function. [PDF]
Sensors (Basel), 2020 Bassoli M, Bianchi V, De Munari I.
europepmc +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Floating-to-Fixed-Point Conversion for Digital Signal Processors
EURASIP Journal on Advances in Signal Processing, 2006 Digital signal processing applications are specified with floating-point data types but they are usually implemented in embedded systems with fixed-point arithmetic to minimise cost and power consumption.
Menard Daniel +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
TFHE Gets Real: an Efficient and Flexible Homomorphic Floating-Point Arithmetic
Transactions on Cryptographic Hardware and Embedded SystemsFloating-point arithmetic plays a central role in computer science and is used in various domains where precision and computational scale are essential.
Loris Bergerat +4 more
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source