Results 181 to 190 of about 381,653 (214)

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

open access: yesAdvanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim   +16 more
wiley   +1 more source

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

open access: yesAdvanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song   +8 more
wiley   +1 more source

Cross-species genomic analysis of <i>Salmonella enterica</i> subspecies <i>enterica</i> serovar Dublin isolated from dairy cattle, dogs, and humans in Florida from 2019 to 2024. [PDF]

open access: yesOne Health
DeZoysa AR   +9 more
europepmc   +1 more source

Correction: Super-Resolution MR Spectroscopic Imaging via Diffusion Models for Tumor Metabolism Mapping. [PDF]

open access: yesJ Imaging Inform Med
Alsubaie M   +5 more
europepmc   +1 more source

A haplotype-resolved, chromosome-scale genome assembly and annotation for Carya glabra (pignut hickory; Juglandaceae). [PDF]

open access: yesG3 (Bethesda)
Shan S   +18 more
europepmc   +1 more source

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