Results 191 to 200 of about 370,672 (258)

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo   +14 more
wiley   +1 more source

WINTER WEATHER IN FLORIDA

open access: yesMonthly Weather Review, 1912
openaire   +2 more sources

Ticks in the Tropics: Challenging the Myth of a Lyme-Less Florida. [PDF]

open access: yesPublic Health Rep
Branstetter B   +4 more
europepmc   +1 more source

Sulfonated Bathocuproine Derivatives as Chemically Bonded Buried‐Interface Engineers for n–i–p Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
A BCP‐derived buried‐interface strategy establishes Na‐BCS as a chemically bonded molecular bridge. By combining sulfonate anchoring to SnO2 with preserved BCP–Pb2+ coordination, Na‐BCS simultaneously passivates oxide‐ and perovskite‐side defects, suppresses non‐radiative recombination, and delivers a surface recombination velocity of 8.6 cm s−1, a ...
Dong Hyun Kim   +9 more
wiley   +1 more source

Linking hosts, landscapes, and climate to advance zoonotic arbovirus forecasting. [PDF]

open access: yesSci Rep
Akshay VA   +8 more
europepmc   +1 more source

Large Language Model‐Informed Dual‐Track AI Framework for the Synergistic Design of Crack‐Free and High‐Strength Superalloys

open access: yesAdvanced Science, EarlyView.
This paper illustrates a knowledge‐augmented dual‐track AI framework for advanced superalloy design. First, Large Language Models translate metallurgical heuristics into explicit rules to rapidly prune a vast compositional search space. Subsequently, LLM‐distilled priors safely guide a reinforcement learning agent during autonomous process optimization,
Jian Yao   +9 more
wiley   +1 more source

Genomic diversity and the domestication history of cotton (<i>Gossypium hirsutum</i>). [PDF]

open access: yesProc Natl Acad Sci U S A
Ning W   +19 more
europepmc   +1 more source

Epidermodysplasia verruciformis successfully treated with cimetidine. [PDF]

open access: yesJAAD Case Rep
Cucalon J   +6 more
europepmc   +1 more source

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