Results 51 to 60 of about 695,722 (268)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

مدلسازی آبشستگی پایین دست یک بند با استفاده از Flow-3D [PDF]

مجله مدل سازی در مهندسی
در مقالۀ حاضر نتاج حاصل از مدل‌سازی عددی عبور آب از روی یک بند و عمق و طول حفرۀ آبشستگی پایین‌دست آن با نتایج آزمایشگاهی انجام شده توسط Muhammad Abbas and Tanaka تحت شرایط هیدرولیکی مختلف شامل دو عمق بحرانی روی تاج سرریز (Dc) برابر 03/0 و 04/0 متر و دو ...
امیر قامتلو, سعید عباسی   +1 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Numerical study of the effect of discharge on flow pattern around a submerged spur dike in an open channel [PDF]

مهندسی منابع آب, 2016
One of the important purposes of river engineering science is to protect river banks from erosion phenomenon and to prevent shifting of the main channel path.
Mohammad Vaghefi, Afshin Eghbalzadeh, Mokhtar Rostamnezhad   +2 more
doaj  

FLOW-3D MODELLING OF THE DEBRIS EFFECT ON MAXIMUM SCOUR HOLE DEPTH AT BRIDGE PIERS [PDF]

38th IAHR World Congress - "Water: Connecting the World", 2019
Bridge foundations are frequently inserted in riverbeds constituted by alluvial material, being, therefore, subjected to scouring processes. Such phenomenon is aggravated during flood events due to the increase of water flow or due to the increase of the debris carried by the flow that can pile up along the bridge structural elements.
Mendonça, Inês Sofia Pereira, Canilho, Hugo Daniel Leitão, Fael, Cristina Maria Sena   +2 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The Effects of Scales on Modeling of Flow Patterns Over Spillway [PDF]

مجلة جامعة النجاح للأبحاث العلوم الطبيعية
Climate changes leading to extreme events when the occurrence and intensity of severe phenomena have impeded the development and rehabilitation of hydraulic infrastructure, such as weirs and spillways according to these new conditions. The scale physical
Humam Khalid Ibrahim, Ammar Hatem Kamel
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source