Results 71 to 80 of about 695,722 (268)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of Hydraulic and Geometric Parameters on Plunge Point in Density Current [PDF]

علوم و مهندسی آبیاری, 2014
When the dense flow mass intersect to stagnant fluid, dense flow penetrates into statically fluid and plunge depth occurs. In this research, hydraulic parameters of density current and bed slope have been investigated, which these have a considering ...
Hassan Goleaje, Mehdi Ghomeshi, Javad Ahadian, Hamed Arjmandi   +3 more
doaj  

بررسی خصوصیات جریان در محل تلاقی دو کانال مرکب (مطالعه عددی) [PDF]

هیدرولیک
تلاقی رودخانه‌ها یا کانال‌ها، پدیده‌ای رایج است. اما علی‌رغم شباهت بیشتر مقاطع رودخانه‌ها به مقطع مرکب و نیز تفاوت‌های آن با مقاطع ساده، به نظر می‌رسد مطالعات جامعی در خصوص تلاقی دو کانال مرکب صورت نگرفته است. برای اعتبارسنجی مدل، نتایج شبیه‌سازی با داده‌
سید محمدمهدی عالمی, حجت کرمی   +1 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

آنالیز بررسی نیروهای هیدرودینامیکی در پرتاب کننده جامی سد (مطالعه موردی : سد جره) [PDF]

هیدرولیک
سرریزها از اصلی‏ترین اجزاء سد می‏باشند که باعث کاهش انرژی مستهلک آب می‏گردند. از جمله سرریزهای که از لحاظ اقتصادی بسیار با صرفه می‏باشند، پرتاب کننده جامی می‏باشد.
غلامحسین اکبری, حامد سرکرده, ایمان لطفی, احسان صدری فیروز آبادی   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

اعتبارسنجی مدل عددی در پیش‌بینی دبی جریان مستغرق با استفاده از داده‌های آزمایشگاهی [PDF]

مدیریت آب و آبیاری
اندازه‌گیری دقیق دبی جریان در شرایط مستغرق همچنان یکی از چالش‌های اساسی در شبکه‌های آبیاری و زهکشی محسوب می‌شود. فلوم‌های قابل‌حمل SMBF، علی‌رغم کاربرد گسترده، در شرایط استغراق با کاهش دقت مواجه هستند.
بهاره راستی پیشه, علی سلاجقه, یونس امین پور, امیرحسین پارسامهر   +3 more
doaj   +1 more source

Assessment of Turbulence Models on Bridge-Pier Scour Using Flow-3D

World Journal of Engineering and Technology, 2019
The main purpose of this paper is to analyze the influence of different turbulence flow models on scouring pit of bridge-pier. Flow-3D software is applied in line with the purpose. The key motivation for this study is to contribute to the Flow-3D software by means of some modification and adjustment in the sediment scour model and shallow water model ...
Chandara Man, Genguang Zhang, Vouchleang Hong, Shuang Zhou, Yulin Feng   +4 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source