Results 61 to 70 of about 695,722 (268)

Effect of inlet and baffle position on the removal efficiency of sedimentation tank using Flow-3D software [PDF]

Journal of Hydraulic Structures
Sedimentation due to gravitation is applied widely in water and wastewater treatment processes to remove suspended solids. This study outlines the effect of the inlet and baffle position on the removal efficiency of sedimentation tanks.
Ali Poorkarimi, Khaled Mafakheri, Shahrzad Maleki   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Numerical investigations of stilling basin efficiency downstream radial gates – A case study of New Assuit Barrage, Egypt [PDF]

Journal of Water and Land Development
Radial gates are more common than vertical sluice gates for a number of reasons. They are simpler to use, cause less flow disturbance, require less lifting force, and deliver better discharge.
Mohamed Elberry, Abdelazim Ali, Fahmy Abdelhaleem, Amir Ibrahim   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Technical Notes on the Near Surface Experiments of Submerged Submarine

International Journal of Maritime Technology, 2016
In this study, the experimental analysis on the bare hull resistance coefficient of submarine at snorkel depth is represented. The experiments are conducted in marine laboratory of Admiral Makarov University.
Mohammad Moonesun, Firouz Ghasemzadeh, Yuri Korol, Valeri Nikrasov, Alexi Yastreba, Alexander Ursolov, Asghar Mahdian   +6 more
doaj  

Influence of Turbulence Models on Simulated Flow Characteristics Over Ogee Spillways

Journal of Studies in Civil Engineering
The study investigated the simulation of flow characteristics over an Ogee-type spillway surface. This research utilizes a Flow-3D numerical model that builds upon the findings from prior experimental data and numerical models simulated by Ansys with a ...
Mangur Rasul Khidhir, Kaywan Othman Ahmed, Jamil Bahrami, Mohsen Isari, Marif Mahmood Karim   +4 more
doaj   +1 more source

Numerical scour modeling around parallel spur dikes in FLOW-3D [PDF]

, 2017
Abstract. Spur dikes are some structures which are built in the flow path with the aim of changing flow characteristics in order to bed and bank protection in rivers. These sudden changes in properties caused by the existence of spur dikes, produces erosion and sedimentation around them. In this paper, effects of series of parallel spur dikes have been
Pourshahbaz, Hanif, Abbasi, Saeed, taghvaei, poorya   +2 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source