Results 91 to 100 of about 9,784,660 (287)

FLOW CHARACTERISTICS OF SKIMMING FLOW IN A STEPPED CHANNEL

PROCEEDINGS OF HYDRAULIC ENGINEERING, 2004
Recently, research onto the hydraulics of stepped chutes was driven by needs for better design guidelines (OHTSU and YASUDA 1997, CHANSON and TOOMBES 2002, BOES and HAGER 2003). Although stepped channel flows are characterized by intense turbulence and strong flow aeration, most studies did not investigate the turbulence characteristics. In this study,
YASUDA, Youichi, TAKAHASHI, Masayuki, OHTSU, Iwao   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Numerical Simulation of the Influence of Riparian Vegetation on Hydrodynamic Characteristics of a Compound River

工程科学与技术, 2023
The riparian vegetation can change the characteristics of the river flow, thereby affecting the bank erosion, bank stability and the river evolution trends. In order to clarify the influence of riparian vegetation on the hydrodynamic characteristics, the
Youzhi HAO, Dongdong JIA, Xingnong ZHANG, Changying CHEN, Lei WU, Jun YANG   +5 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Review and Prospects of Numerical Simulation Research on Internal Flow and Performance Optimization of Twin-Screw Compressors

Energies
The twin-screw compressor exhibits significant application value in the fields of energy, refrigeration, construction, transportation, and related domains. Owing to the benefits of short cycles and low costs, numerical simulation technology has attracted
Yiqiao Li, Xing Zhao, Shan Liu, Chen Wang, Shenqiang Shen, Yali Guo   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Application of CFD Numerical Simulations and Shape Optimization to Modify the Flow Characteristics of Throttle Valves

Energy Engineering and Control Systems
The aim of the study was to perform a numerical analysis using the CFD method of oil flow through a hydraulic valve gap and to perform an optimisation of the gap shape with a view to linearising the valve characteristics.
Alicja Dykas, Urszula Warzyńska
doaj   +1 more source