Results 101 to 110 of about 14,345,300 (303)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Variable structure model for flow-induced tonal noise control with plasma actuators

, 2008
The objective of this work was to study the effect of plasma actuators in attenuating low-speed flow-induced cavitytones from a control point of view by employing techniques from classical control. A modification of the existingphysics-based linear model
Zhang, Xin, Xin Zhang, Steve Gabriel, Chan, Sammie, Xun Huang, Huang, Xun, Gabriel, Steve, Sammie Chan   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Compositional separation of control flow and data flow [PDF]

Journal of Logical and Algebraic Methods in Programming
Every Model of High-Level Computation (MHC) has an underlying composition mechanism for combining simple computing devices into more complex ones. Composition can be done by (explicitly or implicitly) defining control flow, data flow or any combination thereof.
openaire   +4 more sources

Centralized and Distributed Multi-Region Traffic Flow Control

, 2020
In this paper, centralized and distributed multi-region perimeter flow control approaches are proposed for congestion avoidance in urban networks. First, multi-region network dynamics are modeled with Macroscopic Fundamental Diagrams (MFDs) and necessary
Themistoklis Charalambous, Boufous, Omar, Omar Boufous, Roncoli, Claudio, Claudio Roncoli, Charalambous, Themistoklis   +5 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Numerical Investigation of Stage Separation Control of Tandem Hypersonic Vehicles Based on Lateral Jet

Aerospace
The stage separation of hypersonic vehicles is critically challenged by severe aerodynamic interference, which induces significant attitude deviations and jeopardizes subsequent flight missions.
Wenhua Guo, Jiawei Fu, Pengzhen He, Shuling Tian   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Flow Measurement Model of Ultrasonic Flowmeter for Gas-Liquid Two-Phase Stratified and Annular Flows

Advances in Mechanical Engineering, 2014
An error correction model for ultrasonic gas flowmeter was proposed to explore the potential of an ultrasonic flowmeter for metering gas-liquid stratified and annular flows.
Lanchang Xing, Chenquan Hua, Hao Zhu, Wolfgang Drahm   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source